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Needle-shaped ultrathin piezoelectric microsystem for guided tissue targeting via mechanical sensing

Needle-shaped ultrathin piezoelectric microsystem for guided tissue targeting via mechanical sensing
Needle-shaped ultrathin piezoelectric microsystem for guided tissue targeting via mechanical sensing
Needles for percutaneous biopsies of tumour tissue can be guided by ultrasound or computed tomography. However, despite best imaging practices and operator experience, high rates of inadequate tissue sampling, especially for small lesions, are common. Here, we introduce a needle-shaped ultrathin piezoelectric microsystem that can be injected or mounted directly onto conventional biopsy needles and used to distinguish abnormal tissue during the capture of biopsy samples, through quantitative real-time measurements of variations in tissue modulus. Using well-characterized synthetic soft materials, explanted tissues and animal models, we establish experimentally and theoretically the fundamental operating principles of the microsystem, as well as key considerations in materials choices and device designs. Through systematic tests on human livers with cancerous lesions, we demonstrate that the piezoelectric microsystem provides quantitative agreement with magnetic resonance elastography, the clinical gold standard for the measurement of tissue modulus. The piezoelectric microsystem provides a foundation for the design of tools for the rapid, modulus-based characterization of tissues.
2157-846X
165-172
Yu, Xinge
8c5fb321-adfe-4732-84f1-d17b6939b9bb
Wang, Heling
3b78e216-9afc-4b5a-b2f7-4927843b4761
Ning, Xin
277c9304-0c30-4b94-a786-57e243df5a50
Sun, Rujie
e3dad16d-6c79-4972-8378-edca28a3babd
Albadawi, Hassan
cb7a20ad-64b8-49b3-93de-af5486037736
Salomao, Marcela
3694c051-c5b7-49dc-84a3-09d6484f14e5
Silva, Alvin C.
81886441-febb-41e9-b22d-47270568ad1e
Yu, Yang
5075182c-4a2d-454f-8954-f2f29052ae68
Tian, Limei
24c46038-064a-4e42-868b-9e65f911bdd4
Koh, Ahyeon
80262b7d-6e1e-4564-9ee1-3f882fa30a27
Lee, Chan Mi
034600c4-a55d-4246-8793-c3e018a020ca
Chempakasseril, Aditya
4574b802-c863-428d-9aca-9151fe609e49
Tian, Peilin
e38696b7-77bb-4426-9a91-0ef01a2acb3b
Pharr, Matt
d71c9f43-c178-4c17-b6a2-f9a5c4663f78
Yuan, Jianghong
db45145f-d1b6-408b-8ae9-d1afe375ea20
Huang, Yonggang
01e03ce9-0388-4274-8c0b-0a7fc4159bb3
Oklu, Rahmi
d1126b0b-fa3f-4560-9df3-d0e8b178aba2
Rogers, John A.
512058b1-bc48-4659-b7e5-a5e964c92395
Yu, Xinge
8c5fb321-adfe-4732-84f1-d17b6939b9bb
Wang, Heling
3b78e216-9afc-4b5a-b2f7-4927843b4761
Ning, Xin
277c9304-0c30-4b94-a786-57e243df5a50
Sun, Rujie
e3dad16d-6c79-4972-8378-edca28a3babd
Albadawi, Hassan
cb7a20ad-64b8-49b3-93de-af5486037736
Salomao, Marcela
3694c051-c5b7-49dc-84a3-09d6484f14e5
Silva, Alvin C.
81886441-febb-41e9-b22d-47270568ad1e
Yu, Yang
5075182c-4a2d-454f-8954-f2f29052ae68
Tian, Limei
24c46038-064a-4e42-868b-9e65f911bdd4
Koh, Ahyeon
80262b7d-6e1e-4564-9ee1-3f882fa30a27
Lee, Chan Mi
034600c4-a55d-4246-8793-c3e018a020ca
Chempakasseril, Aditya
4574b802-c863-428d-9aca-9151fe609e49
Tian, Peilin
e38696b7-77bb-4426-9a91-0ef01a2acb3b
Pharr, Matt
d71c9f43-c178-4c17-b6a2-f9a5c4663f78
Yuan, Jianghong
db45145f-d1b6-408b-8ae9-d1afe375ea20
Huang, Yonggang
01e03ce9-0388-4274-8c0b-0a7fc4159bb3
Oklu, Rahmi
d1126b0b-fa3f-4560-9df3-d0e8b178aba2
Rogers, John A.
512058b1-bc48-4659-b7e5-a5e964c92395

Yu, Xinge, Wang, Heling, Ning, Xin, Sun, Rujie, Albadawi, Hassan, Salomao, Marcela, Silva, Alvin C., Yu, Yang, Tian, Limei, Koh, Ahyeon, Lee, Chan Mi, Chempakasseril, Aditya, Tian, Peilin, Pharr, Matt, Yuan, Jianghong, Huang, Yonggang, Oklu, Rahmi and Rogers, John A. (2018) Needle-shaped ultrathin piezoelectric microsystem for guided tissue targeting via mechanical sensing. Nature Biomedical Engineering, 2 (3), 165-172. (doi:10.1038/s41551-018-0201-6).

Record type: Article

Abstract

Needles for percutaneous biopsies of tumour tissue can be guided by ultrasound or computed tomography. However, despite best imaging practices and operator experience, high rates of inadequate tissue sampling, especially for small lesions, are common. Here, we introduce a needle-shaped ultrathin piezoelectric microsystem that can be injected or mounted directly onto conventional biopsy needles and used to distinguish abnormal tissue during the capture of biopsy samples, through quantitative real-time measurements of variations in tissue modulus. Using well-characterized synthetic soft materials, explanted tissues and animal models, we establish experimentally and theoretically the fundamental operating principles of the microsystem, as well as key considerations in materials choices and device designs. Through systematic tests on human livers with cancerous lesions, we demonstrate that the piezoelectric microsystem provides quantitative agreement with magnetic resonance elastography, the clinical gold standard for the measurement of tissue modulus. The piezoelectric microsystem provides a foundation for the design of tools for the rapid, modulus-based characterization of tissues.

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More information

Accepted/In Press date: 22 January 2018
e-pub ahead of print date: 26 February 2018

Identifiers

Local EPrints ID: 486915
URI: http://eprints.soton.ac.uk/id/eprint/486915
ISSN: 2157-846X
PURE UUID: 38b53634-2fb4-4e4a-a8f3-96a7ce26e6b3

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Date deposited: 08 Feb 2024 17:39
Last modified: 17 Mar 2024 07:24

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Contributors

Author: Xinge Yu
Author: Heling Wang
Author: Xin Ning
Author: Rujie Sun
Author: Hassan Albadawi
Author: Marcela Salomao
Author: Alvin C. Silva
Author: Yang Yu
Author: Limei Tian
Author: Ahyeon Koh
Author: Chan Mi Lee
Author: Aditya Chempakasseril
Author: Peilin Tian
Author: Matt Pharr
Author: Jianghong Yuan
Author: Yonggang Huang
Author: Rahmi Oklu
Author: John A. Rogers

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