A prospective study of urinary androgen levels and ovarian cancer
A prospective study of urinary androgen levels and ovarian cancer
The three major urinary androgen metabolites, dehydroepiandrosterone (DHEA), androsterone (ANDRO), and aetiocholanolone (AETIO) were measured in 1,484 volunteer women between 29 and 60 years of age on the island of Guernsey from 1962–1967. Twelve of these women subsequently developed ovarian cancer after a median interval of 130 months and a minimum interval of 19 months. All three androgen levels in these women were lower than those in controls matched for age and menopausal status. The results were most striking for DHEA, where half of the cases were below the 27th percentile of their matched controls (p = 0.007, two‐sided). The results for ANDRO were of marginal significance (p = 0.06), and those for AETIO were not significant (p= 0.033).
723-726
Cuzick, Jack
d4827368-ca61-401c-b6d5-416b523e2fe6
Bulstrode, J. C.
99499e5a-beec-4213-aae4-59b575f82e4b
Stratton, I.
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Thomas, B. S.
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Bulbrook, R. D.
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Hayward, J. L.
af6d1d88-24f3-4a30-a5fb-016b033909e2
15 December 1983
Cuzick, Jack
d4827368-ca61-401c-b6d5-416b523e2fe6
Bulstrode, J. C.
99499e5a-beec-4213-aae4-59b575f82e4b
Stratton, I.
772f25b9-23c0-4240-a3f6-1e76b03b172f
Thomas, B. S.
68eb6bc2-e53f-4b98-bd19-f01613de3dd2
Bulbrook, R. D.
9b349cdd-91b6-4eab-9308-3f86e15dcf72
Hayward, J. L.
af6d1d88-24f3-4a30-a5fb-016b033909e2
Cuzick, Jack, Bulstrode, J. C., Stratton, I., Thomas, B. S., Bulbrook, R. D. and Hayward, J. L.
(1983)
A prospective study of urinary androgen levels and ovarian cancer.
International Journal of Cancer, 32 (6), .
(doi:10.1002/ijc.2910320611).
Abstract
The three major urinary androgen metabolites, dehydroepiandrosterone (DHEA), androsterone (ANDRO), and aetiocholanolone (AETIO) were measured in 1,484 volunteer women between 29 and 60 years of age on the island of Guernsey from 1962–1967. Twelve of these women subsequently developed ovarian cancer after a median interval of 130 months and a minimum interval of 19 months. All three androgen levels in these women were lower than those in controls matched for age and menopausal status. The results were most striking for DHEA, where half of the cases were below the 27th percentile of their matched controls (p = 0.007, two‐sided). The results for ANDRO were of marginal significance (p = 0.06), and those for AETIO were not significant (p= 0.033).
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Published date: 15 December 1983
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Local EPrints ID: 486933
URI: http://eprints.soton.ac.uk/id/eprint/486933
ISSN: 0020-7136
PURE UUID: 969c1b21-92a0-4922-9332-0f938f73cc24
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Date deposited: 08 Feb 2024 17:45
Last modified: 18 Mar 2024 04:01
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Author:
Jack Cuzick
Author:
J. C. Bulstrode
Author:
I. Stratton
Author:
B. S. Thomas
Author:
R. D. Bulbrook
Author:
J. L. Hayward
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