Group sequential clinical trials with triangular continuation regions.
Group sequential clinical trials with triangular continuation regions.
In this paper a new class of group sequential procedures for clinical trials is introduced, and the use of these procedures is illustrated by reference to a recently completed comparative study. In a group sequential trial the decision to stop or to continue is made at regular intervals throughout the trial, but not as frequently as after every patient response. This more practical formulation retains most of the advantages of sequential analysis, particularly the economy in sample size. Comparisons are made with group sequential designs derived from the repeated significance test.
227-236
Whitehead, John
a7637ff4-f589-4b84-ba51-0291317b77b1
Stratton, Irene
772f25b9-23c0-4240-a3f6-1e76b03b172f
March 1983
Whitehead, John
a7637ff4-f589-4b84-ba51-0291317b77b1
Stratton, Irene
772f25b9-23c0-4240-a3f6-1e76b03b172f
Whitehead, John and Stratton, Irene
(1983)
Group sequential clinical trials with triangular continuation regions.
Biometrics, 39 (1), .
(doi:10.2307/2530822).
Abstract
In this paper a new class of group sequential procedures for clinical trials is introduced, and the use of these procedures is illustrated by reference to a recently completed comparative study. In a group sequential trial the decision to stop or to continue is made at regular intervals throughout the trial, but not as frequently as after every patient response. This more practical formulation retains most of the advantages of sequential analysis, particularly the economy in sample size. Comparisons are made with group sequential designs derived from the repeated significance test.
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Published date: March 1983
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Local EPrints ID: 486998
URI: http://eprints.soton.ac.uk/id/eprint/486998
ISSN: 0006-341X
PURE UUID: 6d31f7d1-a4b9-4c12-9b34-4070fa6e8646
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Date deposited: 09 Feb 2024 17:36
Last modified: 18 Mar 2024 04:01
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Author:
John Whitehead
Author:
Irene Stratton
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