The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56)
The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56)
A definitive model for predicting absolute risk of coronary heart disease (CHD) in male and female people with Type II diabetes is not yet available. This paper provides an equation for estimating the risk of new CHD events in people with Type II diabetes, based on data from 4540 U.K. Prospective Diabetes Study male and female patients. Unlike previously published risk equations, the model is diabetes-specific and incorporates glycaemia, systolic blood pressure and lipid levels as risk factors, in addition to age, sex, ethnic group, smoking status and time since diagnosis of diabetes. All variables included in the final model were statistically significant (P < 0.001, except smoking for which P = 0.0013) in likelihood ratio testing. This model provides the estimates of CHD risk required by current guidelines for the primary prevention of CHD in Type II diabetes.
Adult, Blood Pressure, Coronary Disease/ethnology, Diabetes Mellitus, Type 2/blood, Diabetic Angiopathies/ethnology, Female, Follow-Up Studies, Glycated Hemoglobin/analysis, Humans, Lipids/blood, Male, Middle Aged, Models, Statistical, Risk Assessment/methods, Risk Factors, Smoking/adverse effects, Survival Rate
671-679
Stevens, Richard J.
9fb383b3-a226-4582-86c9-81b56d3f07e7
Kothari, Viti
f88cb53e-00e3-4459-8957-f7f8f4e1887b
Adler, Amanda I.
d02dfdd6-ca6f-4cdc-91ab-8eb79ff94d7f
Stratton, Irene M.
772f25b9-23c0-4240-a3f6-1e76b03b172f
Holman, Rury R.
336fb2f7-edb5-4d65-a7b0-465111cbd047
on behalf of the United Kingdom Prospective Diabetes Study (UKPDS) Group
21 November 2001
Stevens, Richard J.
9fb383b3-a226-4582-86c9-81b56d3f07e7
Kothari, Viti
f88cb53e-00e3-4459-8957-f7f8f4e1887b
Adler, Amanda I.
d02dfdd6-ca6f-4cdc-91ab-8eb79ff94d7f
Stratton, Irene M.
772f25b9-23c0-4240-a3f6-1e76b03b172f
Holman, Rury R.
336fb2f7-edb5-4d65-a7b0-465111cbd047
Stevens, Richard J., Kothari, Viti, Adler, Amanda I., Stratton, Irene M. and Holman, Rury R.
,
on behalf of the United Kingdom Prospective Diabetes Study (UKPDS) Group
(2001)
The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56).
Clinical Science, 101 (6), .
(doi:10.1042/cs1010671).
Abstract
A definitive model for predicting absolute risk of coronary heart disease (CHD) in male and female people with Type II diabetes is not yet available. This paper provides an equation for estimating the risk of new CHD events in people with Type II diabetes, based on data from 4540 U.K. Prospective Diabetes Study male and female patients. Unlike previously published risk equations, the model is diabetes-specific and incorporates glycaemia, systolic blood pressure and lipid levels as risk factors, in addition to age, sex, ethnic group, smoking status and time since diagnosis of diabetes. All variables included in the final model were statistically significant (P < 0.001, except smoking for which P = 0.0013) in likelihood ratio testing. This model provides the estimates of CHD risk required by current guidelines for the primary prevention of CHD in Type II diabetes.
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More information
Published date: 21 November 2001
Additional Information:
A correction has been attached to this output located at https://doi.org/10.1042/cs1020679 and https://portlandpress.com/clinsci/article/102/6/679/67282/The-UKPDS-risk-engine-a-model-for-the-risk-of
Keywords:
Adult, Blood Pressure, Coronary Disease/ethnology, Diabetes Mellitus, Type 2/blood, Diabetic Angiopathies/ethnology, Female, Follow-Up Studies, Glycated Hemoglobin/analysis, Humans, Lipids/blood, Male, Middle Aged, Models, Statistical, Risk Assessment/methods, Risk Factors, Smoking/adverse effects, Survival Rate
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Local EPrints ID: 487028
URI: http://eprints.soton.ac.uk/id/eprint/487028
ISSN: 0143-5221
PURE UUID: 8ceb28db-35ae-4139-bab1-cec3254a8dba
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Date deposited: 09 Feb 2024 17:47
Last modified: 18 Mar 2024 04:01
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Contributors
Author:
Richard J. Stevens
Author:
Viti Kothari
Author:
Amanda I. Adler
Author:
Irene M. Stratton
Author:
Rury R. Holman
Corporate Author: on behalf of the United Kingdom Prospective Diabetes Study (UKPDS) Group
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