A simple risk stratification for time to development of sight-threatening diabetic retinopathy
A simple risk stratification for time to development of sight-threatening diabetic retinopathy
Oobjective: the American Diabetes Association and the English NHS Diabetic Eye Screening Program recommend annual screening for diabetic retinopathy (DR) with referral to ophthalmology clinics of patients with sight-threatening DR (STDR). Using only longitudinal data from retinal photographs in the population-based NHS Diabetic Eye Screening Program in Gloucestershire, we developed a simple means to estimate risk of STDR.
Research design and methods: from 2005, 14,554 patients with no DR or mild nonproliferative DR only at two consecutive annual digital photographic screenings were categorized by the presence of DR in neither, one, or both eyes at each screening and were followed for a further median 2.8 years.
Results: of 7,246 with no DR at either screening, 120 progressed to STDR, equivalent to an annual rate of 0.7%. Of 1,778 with no DR in either eye at first screening and in one eye at second screening, 80 progressed to STDR, equivalent to an annual rate of 1.9% and to a hazard ratio (HR) of 2.9 (95% CI 2.2–3.8) compared with those with no DR. Of 1,159 with background DR in both eyes at both screenings, 299 progressed to STDR equivalent to an annual rate of 11% and an HR of 18.2 (14.7–22.5) compared with individuals with no DR.
Conclusions: combining the results from 2 consecutive years of photographic screening enables estimation of the risk of future development of STDR. In countries with systematic screening programs, these results could inform decisions about screening frequency.
580-585
Stratton, Irene M.
772f25b9-23c0-4240-a3f6-1e76b03b172f
Aldington, Stephen J.
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Taylor, David J.
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Adler, Amanda I.
d02dfdd6-ca6f-4cdc-91ab-8eb79ff94d7f
Scanlon, Peter H.
4e3d2310-c79e-42db-ae29-7a7d6b278aa3
March 2013
Stratton, Irene M.
772f25b9-23c0-4240-a3f6-1e76b03b172f
Aldington, Stephen J.
0d0ac922-21f1-4198-91eb-893231cc53c4
Taylor, David J.
e03189d9-fc48-48e5-9c4b-4930be23ad75
Adler, Amanda I.
d02dfdd6-ca6f-4cdc-91ab-8eb79ff94d7f
Scanlon, Peter H.
4e3d2310-c79e-42db-ae29-7a7d6b278aa3
Stratton, Irene M., Aldington, Stephen J., Taylor, David J., Adler, Amanda I. and Scanlon, Peter H.
(2013)
A simple risk stratification for time to development of sight-threatening diabetic retinopathy.
Diabetes Care, 36 (3), .
(doi:10.2337/dc12-0625).
Abstract
Oobjective: the American Diabetes Association and the English NHS Diabetic Eye Screening Program recommend annual screening for diabetic retinopathy (DR) with referral to ophthalmology clinics of patients with sight-threatening DR (STDR). Using only longitudinal data from retinal photographs in the population-based NHS Diabetic Eye Screening Program in Gloucestershire, we developed a simple means to estimate risk of STDR.
Research design and methods: from 2005, 14,554 patients with no DR or mild nonproliferative DR only at two consecutive annual digital photographic screenings were categorized by the presence of DR in neither, one, or both eyes at each screening and were followed for a further median 2.8 years.
Results: of 7,246 with no DR at either screening, 120 progressed to STDR, equivalent to an annual rate of 0.7%. Of 1,778 with no DR in either eye at first screening and in one eye at second screening, 80 progressed to STDR, equivalent to an annual rate of 1.9% and to a hazard ratio (HR) of 2.9 (95% CI 2.2–3.8) compared with those with no DR. Of 1,159 with background DR in both eyes at both screenings, 299 progressed to STDR equivalent to an annual rate of 11% and an HR of 18.2 (14.7–22.5) compared with individuals with no DR.
Conclusions: combining the results from 2 consecutive years of photographic screening enables estimation of the risk of future development of STDR. In countries with systematic screening programs, these results could inform decisions about screening frequency.
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Accepted/In Press date: 13 August 2012
e-pub ahead of print date: 13 February 2013
Published date: March 2013
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Local EPrints ID: 487117
URI: http://eprints.soton.ac.uk/id/eprint/487117
ISSN: 0149-5992
PURE UUID: 6194b96f-13a3-4669-a976-0309a9528f03
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Date deposited: 14 Feb 2024 17:36
Last modified: 18 Mar 2024 04:01
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Contributors
Author:
Irene M. Stratton
Author:
Stephen J. Aldington
Author:
David J. Taylor
Author:
Amanda I. Adler
Author:
Peter H. Scanlon
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