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Current status and future trends of the global burden of MASLD

Current status and future trends of the global burden of MASLD
Current status and future trends of the global burden of MASLD

Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most common chronic liver disease globally, affecting more than a third of the world's adult population. This comprehensive narrative review summarizes the global incidence and prevalence rates of MASLD and its related adverse hepatic and extrahepatic outcomes. We also discuss the substantial economic burden of MASLD on healthcare systems, thus further highlighting the urgent need for global efforts to tackle this common and burdensome liver condition. We emphasize the clinical relevance of early interventions and a holistic approach that includes public health strategies to reduce the global impact of MASLD.

disease burden, epidemiology, metabolic dysfunction-associated fatty liver disease, metabolic dysfunction-associated steatohepatitis, metabolic dysfunction-associated steatotic liver disease, non-alcoholic fatty liver disease
1043-2760
Miao, Lei
31dcc08c-f23f-4a37-88c8-235adf730cd6
Targher, Giovanni
279742db-21b3-46b9-9ea6-fe42a7efb71b
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Cao, Ying-Ying
59a01cf4-4743-4019-899e-bb24cb2ef403
Zheng, Ming-Hua
743445eb-723d-4714-9031-ed989be4fb1a
Miao, Lei
31dcc08c-f23f-4a37-88c8-235adf730cd6
Targher, Giovanni
279742db-21b3-46b9-9ea6-fe42a7efb71b
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Cao, Ying-Ying
59a01cf4-4743-4019-899e-bb24cb2ef403
Zheng, Ming-Hua
743445eb-723d-4714-9031-ed989be4fb1a

Miao, Lei, Targher, Giovanni, Byrne, Christopher D., Cao, Ying-Ying and Zheng, Ming-Hua (2024) Current status and future trends of the global burden of MASLD. Trends in Endocrinology & Metabolism. (doi:10.1016/j.tem.2024.02.007).

Record type: Review

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most common chronic liver disease globally, affecting more than a third of the world's adult population. This comprehensive narrative review summarizes the global incidence and prevalence rates of MASLD and its related adverse hepatic and extrahepatic outcomes. We also discuss the substantial economic burden of MASLD on healthcare systems, thus further highlighting the urgent need for global efforts to tackle this common and burdensome liver condition. We emphasize the clinical relevance of early interventions and a holistic approach that includes public health strategies to reduce the global impact of MASLD.

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draft-R1 20240205 (002) - Accepted Manuscript
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highlights 20240205 - Accepted Manuscript
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outstanding questions 20240205 - Accepted Manuscript
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Figure 1 - Accepted Manuscript
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Figure 2 - Accepted Manuscript
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Figure 3 - Accepted Manuscript
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More information

Accepted/In Press date: 12 February 2024
e-pub ahead of print date: 29 February 2024
Published date: 29 February 2024
Additional Information: Publisher Copyright: © 2024 Elsevier Ltd
Keywords: disease burden, epidemiology, metabolic dysfunction-associated fatty liver disease, metabolic dysfunction-associated steatohepatitis, metabolic dysfunction-associated steatotic liver disease, non-alcoholic fatty liver disease

Identifiers

Local EPrints ID: 487123
URI: http://eprints.soton.ac.uk/id/eprint/487123
DOI: doi:10.1016/j.tem.2024.02.007
ISSN: 1043-2760
PURE UUID: cd2d22a6-4dcf-43b8-8f43-216cc0c50f0c
ORCID for Christopher D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

Catalogue record

Date deposited: 14 Feb 2024 17:37
Last modified: 27 Apr 2024 01:38

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Contributors

Author: Lei Miao
Author: Giovanni Targher
Author: Christopher D. Byrne ORCID iD
Author: Ying-Ying Cao
Author: Ming-Hua Zheng

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