Prevalence and incidence of diabetic retinopathy (DR) in the UK population of Gloucestershire
Prevalence and incidence of diabetic retinopathy (DR) in the UK population of Gloucestershire
Purpose: to estimate prevalence and incidence of diabetic retinopathy (DR) in a UK region by severity between 2012 and 2016 and risk factors for progression to proliferative DR (PDR).
Methods: electronic medical records from people with diabetes (PWD) ≥18 years seen at the Gloucestershire Diabetic Eye Screening Programme (GDESP) and the hospital eye clinic were analysed (HEC). Prevalence and incidence of DR per 100 PWD (%) by calendar year, grade and diabetes type were estimated using log-linear regression. Progression to PDR and associated risk factors were estimated using parametric survival analyses.
Results: across the study period, 35 873 PWD had at least one DR assessment. They were aged 66 (56–75) years (median (interquartile range)), 57% male, 5 (1–10) years since diabetes diagnosis, 93% Type 2 diabetes. Prevalence of DR decreased from 38.9% (95% CI: 38.1%, 39.8%) in 2012 to 36.6% (95% CI: 35.9%, 37.3%) in 2016 (p < 0.001). Incidence of any DR decreased from 10.9% (95% CI: 10.4%, 11.5%) in 2013 to 8.5% (95% CI: 8.1%, 9.0%) in 2016 (p < 0.001). Prevalence of PDR decreased from 3.5% (95% CI: 3.3%, 3.8%) in 2012 to 3.1% (95% CI 2.9%, 3.3%) in 2016 (p = 0.008). Incidence of PDR did not change over time. HbA1c and bilateral moderate–severe NPDR were statistically significant risk factors associated with progression to PDR.
Conclusions: incidence and prevalence of DR decreased between 2012 and 2016 in this well-characterized population of the UK.
diabetic retinopathy, epidemiology, imaging, retinal screening, sight-threatening diabetic retinopathy
e560-e570
Scanlon, Peter H.
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Nevill, Clareece R.
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Stratton, Irene M.
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Maruti, Sonia S.
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Massó-González, Elvira L.
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Sivaprasad, Sobha
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Bailey, Clare
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Ehrlich, Michael
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Chong, Victor
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March 2022
Scanlon, Peter H.
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Nevill, Clareece R.
c1ea5279-40f7-4525-8294-bd923b8bb7f3
Stratton, Irene M.
772f25b9-23c0-4240-a3f6-1e76b03b172f
Maruti, Sonia S.
1e4ac8f6-4678-4b59-ae84-0225d0e6a274
Massó-González, Elvira L.
881530ca-5ce1-4726-a51c-1afcdc63a785
Sivaprasad, Sobha
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Bailey, Clare
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Ehrlich, Michael
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Chong, Victor
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Scanlon, Peter H., Nevill, Clareece R., Stratton, Irene M., Maruti, Sonia S., Massó-González, Elvira L., Sivaprasad, Sobha, Bailey, Clare, Ehrlich, Michael and Chong, Victor
(2022)
Prevalence and incidence of diabetic retinopathy (DR) in the UK population of Gloucestershire.
Acta Ophthalmologica, 100 (2), .
(doi:10.1111/aos.14927).
Abstract
Purpose: to estimate prevalence and incidence of diabetic retinopathy (DR) in a UK region by severity between 2012 and 2016 and risk factors for progression to proliferative DR (PDR).
Methods: electronic medical records from people with diabetes (PWD) ≥18 years seen at the Gloucestershire Diabetic Eye Screening Programme (GDESP) and the hospital eye clinic were analysed (HEC). Prevalence and incidence of DR per 100 PWD (%) by calendar year, grade and diabetes type were estimated using log-linear regression. Progression to PDR and associated risk factors were estimated using parametric survival analyses.
Results: across the study period, 35 873 PWD had at least one DR assessment. They were aged 66 (56–75) years (median (interquartile range)), 57% male, 5 (1–10) years since diabetes diagnosis, 93% Type 2 diabetes. Prevalence of DR decreased from 38.9% (95% CI: 38.1%, 39.8%) in 2012 to 36.6% (95% CI: 35.9%, 37.3%) in 2016 (p < 0.001). Incidence of any DR decreased from 10.9% (95% CI: 10.4%, 11.5%) in 2013 to 8.5% (95% CI: 8.1%, 9.0%) in 2016 (p < 0.001). Prevalence of PDR decreased from 3.5% (95% CI: 3.3%, 3.8%) in 2012 to 3.1% (95% CI 2.9%, 3.3%) in 2016 (p = 0.008). Incidence of PDR did not change over time. HbA1c and bilateral moderate–severe NPDR were statistically significant risk factors associated with progression to PDR.
Conclusions: incidence and prevalence of DR decreased between 2012 and 2016 in this well-characterized population of the UK.
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Acta Ophthalmologica - 2021 - Scanlon - Prevalence and incidence of diabetic retinopathy DR in the UK population of
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e-pub ahead of print date: 28 June 2021
Published date: March 2022
Additional Information:
Funding Information:
The study was funded by Boehringer Ingelheim International GmBH.
Keywords:
diabetic retinopathy, epidemiology, imaging, retinal screening, sight-threatening diabetic retinopathy
Identifiers
Local EPrints ID: 487208
URI: http://eprints.soton.ac.uk/id/eprint/487208
ISSN: 1755-375X
PURE UUID: 9c71aec7-c552-4f44-8c12-3e0e0b3c9722
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Date deposited: 16 Feb 2024 10:31
Last modified: 18 Mar 2024 04:01
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Contributors
Author:
Peter H. Scanlon
Author:
Clareece R. Nevill
Author:
Irene M. Stratton
Author:
Sonia S. Maruti
Author:
Elvira L. Massó-González
Author:
Sobha Sivaprasad
Author:
Clare Bailey
Author:
Michael Ehrlich
Author:
Victor Chong
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