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A wireless battery-free eye modulation patch for high myopia therapy

A wireless battery-free eye modulation patch for high myopia therapy
A wireless battery-free eye modulation patch for high myopia therapy
The proper axial length of the eye is crucial for achieving emmetropia. In this study, we present a wireless battery-free eye modulation patch designed to correct high myopia and prevent relapse. The patch consists of piezoelectric transducers, an electrochemical micro-actuator, a drug microneedle array, μ-LEDs, a flexible circuit, and biocompatible encapsulation. The system can be wirelessly powered and controlled using external ultrasound. The electrochemical micro-actuator plays a key role in precisely shortening the axial length by driving the posterior sclera inward. This ensures accurate scene imaging on the retina for myopia eye. The drug microneedle array delivers riboflavin to the posterior sclera, and μ-LEDs' blue light induces collagen cross-linking, reinforcing sclera strength. In vivo experiments demonstrate that the patch successfully reduces the rabbit eye's axial length by ~1217 μm and increases sclera strength by 387%. The system operates effectively within the body without the need for batteries. Here, we show that the patch offers a promising avenue for clinically treating high myopia.
2041-1723
Zhong, Tianyan
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Yi, Hangjin
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Gou, Jiacheng
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Li, Jie
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Liu, Miao
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Gao, Xing
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Chen, Sizhu
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Guan, Hongye
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Liang, Shan
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He, Qianxiong
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Lin, Rui
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Long, Zhihe
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Wang, Yue
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Shi, Chuang
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Zhan, Yang
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Zhang, Yan
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Xing, Lili
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Zhong, Jie
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Xue, Xinyu
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Zhong, Tianyan
d6507af7-eada-48fb-bbba-573ee57cf977
Yi, Hangjin
842d73ce-be18-447d-bbc9-48ae08e32bba
Gou, Jiacheng
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Li, Jie
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Liu, Miao
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Gao, Xing
5d11a58f-f607-4618-b55b-dff03e8e4b4f
Chen, Sizhu
7b25e352-d141-4514-93e9-4a8234e684d6
Guan, Hongye
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Liang, Shan
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He, Qianxiong
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Lin, Rui
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Long, Zhihe
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Wang, Yue
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Shi, Chuang
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Zhan, Yang
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Zhang, Yan
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Xing, Lili
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Zhong, Jie
d7a77b20-4225-45b1-9796-6bab76e06a44
Xue, Xinyu
57aa35c5-aa38-4fae-b55d-549fcddf2105

Zhong, Tianyan, Yi, Hangjin, Gou, Jiacheng, Li, Jie, Liu, Miao, Gao, Xing, Chen, Sizhu, Guan, Hongye, Liang, Shan, He, Qianxiong, Lin, Rui, Long, Zhihe, Wang, Yue, Shi, Chuang, Zhan, Yang, Zhang, Yan, Xing, Lili, Zhong, Jie and Xue, Xinyu (2024) A wireless battery-free eye modulation patch for high myopia therapy. Nature Communications, 15 (1), [1766]. (doi:10.1038/s41467-024-46049-6).

Record type: Article

Abstract

The proper axial length of the eye is crucial for achieving emmetropia. In this study, we present a wireless battery-free eye modulation patch designed to correct high myopia and prevent relapse. The patch consists of piezoelectric transducers, an electrochemical micro-actuator, a drug microneedle array, μ-LEDs, a flexible circuit, and biocompatible encapsulation. The system can be wirelessly powered and controlled using external ultrasound. The electrochemical micro-actuator plays a key role in precisely shortening the axial length by driving the posterior sclera inward. This ensures accurate scene imaging on the retina for myopia eye. The drug microneedle array delivers riboflavin to the posterior sclera, and μ-LEDs' blue light induces collagen cross-linking, reinforcing sclera strength. In vivo experiments demonstrate that the patch successfully reduces the rabbit eye's axial length by ~1217 μm and increases sclera strength by 387%. The system operates effectively within the body without the need for batteries. Here, we show that the patch offers a promising avenue for clinically treating high myopia.

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Accepted/In Press date: 12 February 2024
e-pub ahead of print date: 26 February 2024
Published date: 26 February 2024
Additional Information: Publisher Copyright: © The Author(s) 2024.

Identifiers

Local EPrints ID: 487399
URI: http://eprints.soton.ac.uk/id/eprint/487399
ISSN: 2041-1723
PURE UUID: c38d5a5e-de21-4e20-bda7-b346b3858f85
ORCID for Chuang Shi: ORCID iD orcid.org/0000-0002-1517-2775

Catalogue record

Date deposited: 20 Feb 2024 12:44
Last modified: 06 Jun 2024 02:18

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Contributors

Author: Tianyan Zhong
Author: Hangjin Yi
Author: Jiacheng Gou
Author: Jie Li
Author: Miao Liu
Author: Xing Gao
Author: Sizhu Chen
Author: Hongye Guan
Author: Shan Liang
Author: Qianxiong He
Author: Rui Lin
Author: Zhihe Long
Author: Yue Wang
Author: Chuang Shi ORCID iD
Author: Yang Zhan
Author: Yan Zhang
Author: Lili Xing
Author: Jie Zhong
Author: Xinyu Xue

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