Zhong, Tianyan, Yi, Hangjin, Gou, Jiacheng, Li, Jie, Liu, Miao, Gao, Xing, Chen, Sizhu, Guan, Hongye, Liang, Shan, He, Qianxiong, Lin, Rui, Long, Zhihe, Wang, Yue, Shi, Chuang, Zhan, Yang, Zhang, Yan, Xing, Lili, Zhong, Jie and Xue, Xinyu (2024) A wireless battery-free eye modulation patch for high myopia therapy. Nature Communications, 15 (1), [1766]. (doi:10.1038/s41467-024-46049-6).
Abstract
The proper axial length of the eye is crucial for achieving emmetropia. In this study, we present a wireless battery-free eye modulation patch designed to correct high myopia and prevent relapse. The patch consists of piezoelectric transducers, an electrochemical micro-actuator, a drug microneedle array, μ-LEDs, a flexible circuit, and biocompatible encapsulation. The system can be wirelessly powered and controlled using external ultrasound. The electrochemical micro-actuator plays a key role in precisely shortening the axial length by driving the posterior sclera inward. This ensures accurate scene imaging on the retina for myopia eye. The drug microneedle array delivers riboflavin to the posterior sclera, and μ-LEDs' blue light induces collagen cross-linking, reinforcing sclera strength. In vivo experiments demonstrate that the patch successfully reduces the rabbit eye's axial length by ~1217 μm and increases sclera strength by 387%. The system operates effectively within the body without the need for batteries. Here, we show that the patch offers a promising avenue for clinically treating high myopia.
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