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Food allergy outside the eight big foods in Europe: A systematic review and meta-analysis

Food allergy outside the eight big foods in Europe: A systematic review and meta-analysis
Food allergy outside the eight big foods in Europe: A systematic review and meta-analysis

Background: The 2014 estimates of prevalence of food allergy (FA) in Europe published by the European Academy of Allergy and Clinical Immunology included only the eight so-called big foods (cow's milk/egg/wheat/soy/peanut/tree nuts/fish/shellfish). Those estimates have recently been updated. Complementing this, we sought to identify and estimate the prevalence of allergy to other foods that have been reported during the last decade. Methods: Six databases were searched for studies published 2012–2021. Random-effects meta-analysis was performed to derive pooled prevalence of allergy to each food. Results: Twenty-seven studies were included, containing a total of 66 FAs. Among the most frequently reported FAs, the lifetime and point prevalence range of self-reported kiwi allergy was 0.1%–1.0% and 0.2%–8.1%, respectively, while the food challenge (FC)-verified kiwi allergy point prevalence range was 0.01%–0.10%. The point prevalence range for self-reported peach allergy was 0.2%–3.2%, while the range for FC-verified peach allergy was 0.02%–0.05%. The lifetime and point prevalence range for self-reported tomato allergy was 0.01%–1.8% and 0.2%–2.1%, respectively. Conclusion: Allergy to some foods traditionally not considered important are now emerging as relevant FAs. The focus on FA in Europe should not be limited to the so-called eight big FA, but extended to other types of foods which need to be considered both for clinical purposes and population risk assessment.

epidemiology, Europe, food allergy, sensitization, systematic review
2045-7022
Spolidoro, Giulia C.I.
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Nyassi, Sungkutu
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Lisik, Daniil
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Ioannidou, Athina
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Ali, Mohamed Mustafa
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Amera, Yohannes Tesfaye
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Rovner, Graciela
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Khaleva, Ekaterina
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Venter, Carina
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van Ree, Ronald
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Worm, Margitta
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Vlieg-Boerstra, Berber
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Sheikh, Aziz
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Muraro, Antonella
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Roberts, Graham
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Nwaru, Bright I.
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Spolidoro, Giulia C.I.
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Nyassi, Sungkutu
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Lisik, Daniil
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Ioannidou, Athina
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Ali, Mohamed Mustafa
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Amera, Yohannes Tesfaye
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Rovner, Graciela
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Khaleva, Ekaterina
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Venter, Carina
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van Ree, Ronald
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Worm, Margitta
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Vlieg-Boerstra, Berber
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Sheikh, Aziz
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Muraro, Antonella
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Roberts, Graham
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Nwaru, Bright I.
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Spolidoro, Giulia C.I., Nyassi, Sungkutu, Lisik, Daniil, Ioannidou, Athina, Ali, Mohamed Mustafa, Amera, Yohannes Tesfaye, Rovner, Graciela, Khaleva, Ekaterina, Venter, Carina, van Ree, Ronald, Worm, Margitta, Vlieg-Boerstra, Berber, Sheikh, Aziz, Muraro, Antonella, Roberts, Graham and Nwaru, Bright I. (2024) Food allergy outside the eight big foods in Europe: A systematic review and meta-analysis. Clinical and Translational Allergy, 14 (2), [e12338]. (doi:10.1002/clt2.12338).

Record type: Review

Abstract

Background: The 2014 estimates of prevalence of food allergy (FA) in Europe published by the European Academy of Allergy and Clinical Immunology included only the eight so-called big foods (cow's milk/egg/wheat/soy/peanut/tree nuts/fish/shellfish). Those estimates have recently been updated. Complementing this, we sought to identify and estimate the prevalence of allergy to other foods that have been reported during the last decade. Methods: Six databases were searched for studies published 2012–2021. Random-effects meta-analysis was performed to derive pooled prevalence of allergy to each food. Results: Twenty-seven studies were included, containing a total of 66 FAs. Among the most frequently reported FAs, the lifetime and point prevalence range of self-reported kiwi allergy was 0.1%–1.0% and 0.2%–8.1%, respectively, while the food challenge (FC)-verified kiwi allergy point prevalence range was 0.01%–0.10%. The point prevalence range for self-reported peach allergy was 0.2%–3.2%, while the range for FC-verified peach allergy was 0.02%–0.05%. The lifetime and point prevalence range for self-reported tomato allergy was 0.01%–1.8% and 0.2%–2.1%, respectively. Conclusion: Allergy to some foods traditionally not considered important are now emerging as relevant FAs. The focus on FA in Europe should not be limited to the so-called eight big FA, but extended to other types of foods which need to be considered both for clinical purposes and population risk assessment.

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Accepted/In Press date: 24 January 2024
Published date: 7 February 2024
Additional Information: Funding Information: The study was funded through an unrestricted grant from DBV Technologies SA. The funders had no influence on the design of the study, interpretation of findings, or the decision to publish. BN acknowledges the support of Knut and Alice Wallenberg Foundation, the Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Sweden, and the VBG Group Herman Krefting Foundation on Asthma and Allergy. Funding Information: Carina Venter reports grants (Reckitt Benckiser, Food Allergy Research and Education, and National Peanut Board) and personal fees (Reckitt Benckiser, Nestle Nutrition Institute, Danone, Abbott Nutrition, Else Nutrition, Sifter, and Before Brands). Ronald van Ree reports consultancies (HAL Allergy BV, Citeq BV, Angany Inc., Reacta Healthcare Ltd., Mission MightyMe, AB Enzymes, The Protein Brewery, and Unilever India), speaker's fees (HAL Allergy BV, ThermoFisher Scientific, and ALK), and stock options (Angany Inc.). Margitta Worm reports grants and personal fees (Stallergènes, HAL Allergy, Bencard Allergie, Allergopharma, ALK‐Abello, Mylan Germany, Actelion Pharmaceuticals Deutschland, Biotest, AbbVie Deutschland, Lilly Deutschland Aimmune, DBV Technologies SA, Regeneron Pharmaceuticals, Sanofi Aventis, Leo Pharma, Novartis, and Viatris) outside the submitted work and being past WAO co‐chair of the anaphylaxis committee and past chair of the food allergy interest group of EAACI. Berber Vlieg‐Boerstra reports personal and speaker fees (Vinimini, Nestlé, and Nutricia) and grants (Nutricia). Antonella Muraro reports grants and speaker's fees (Aimmune), speaker's fees (DVB Technologies SA, Viatris [Mylan], ALK, and Nestlé), and being a member of the Executive Committee of GA2LEN and past president of EAACI. Graham Roberts reports grants (Asthma UK and National Institutes of Health Research). Bright Nwaru reports unrestricted grants and personal fees from DBV Technologies and AstraZeneca, respectively. Giulia C.I. Spolidoro, Yohannes Tesfaye Amera, Mohamed Mustafa Ali, Sungkutu Nyassi, Daniil Lisik, and Athina Ioannidou report fees from ACT Institutet Sweden. The other authors report no conflicting interests related to this work. The funder played no role in the content and decision to submit this manuscript. Publisher Copyright: © 2024 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.
Keywords: epidemiology, Europe, food allergy, sensitization, systematic review

Identifiers

Local EPrints ID: 487641
URI: http://eprints.soton.ac.uk/id/eprint/487641
ISSN: 2045-7022
PURE UUID: 90cf9cd0-3569-477f-9f0b-90a85714aabf
ORCID for Ekaterina Khaleva: ORCID iD orcid.org/0000-0002-2220-7745
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

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Date deposited: 29 Feb 2024 17:55
Last modified: 17 Aug 2024 02:05

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Contributors

Author: Giulia C.I. Spolidoro
Author: Sungkutu Nyassi
Author: Daniil Lisik
Author: Athina Ioannidou
Author: Mohamed Mustafa Ali
Author: Yohannes Tesfaye Amera
Author: Graciela Rovner
Author: Ekaterina Khaleva ORCID iD
Author: Carina Venter
Author: Ronald van Ree
Author: Margitta Worm
Author: Berber Vlieg-Boerstra
Author: Aziz Sheikh
Author: Antonella Muraro
Author: Graham Roberts ORCID iD
Author: Bright I. Nwaru

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