The University of Southampton
University of Southampton Institutional Repository

Food allergy outside the eight big foods in Europe: A systematic review and meta-analysis

Food allergy outside the eight big foods in Europe: A systematic review and meta-analysis
Food allergy outside the eight big foods in Europe: A systematic review and meta-analysis

Background: The 2014 estimates of prevalence of food allergy (FA) in Europe published by the European Academy of Allergy and Clinical Immunology included only the eight so-called big foods (cow's milk/egg/wheat/soy/peanut/tree nuts/fish/shellfish). Those estimates have recently been updated. Complementing this, we sought to identify and estimate the prevalence of allergy to other foods that have been reported during the last decade. Methods: Six databases were searched for studies published 2012–2021. Random-effects meta-analysis was performed to derive pooled prevalence of allergy to each food. Results: Twenty-seven studies were included, containing a total of 66 FAs. Among the most frequently reported FAs, the lifetime and point prevalence range of self-reported kiwi allergy was 0.1%–1.0% and 0.2%–8.1%, respectively, while the food challenge (FC)-verified kiwi allergy point prevalence range was 0.01%–0.10%. The point prevalence range for self-reported peach allergy was 0.2%–3.2%, while the range for FC-verified peach allergy was 0.02%–0.05%. The lifetime and point prevalence range for self-reported tomato allergy was 0.01%–1.8% and 0.2%–2.1%, respectively. Conclusion: Allergy to some foods traditionally not considered important are now emerging as relevant FAs. The focus on FA in Europe should not be limited to the so-called eight big FA, but extended to other types of foods which need to be considered both for clinical purposes and population risk assessment.

epidemiology, Europe, food allergy, sensitization, systematic review
2045-7022
Spolidoro, Giulia C.I.
e43ddf6b-a83e-43b0-8eeb-fc7ef25d7e5e
Nyassi, Sungkutu
dfb4ac84-a174-4fe7-aa7c-7b2ada500443
Lisik, Daniil
97db115a-4f08-4768-b304-e12b95002781
Ioannidou, Athina
af08924d-bc9e-4d67-aded-3d54f4ac617d
Ali, Mohamed Mustafa
2c8ea880-4cad-4475-af0f-02d691680f8f
Amera, Yohannes Tesfaye
c1e9e638-ebb4-484d-86dd-e85b717e79a0
Rovner, Graciela
8a8bf134-4f54-4ad7-a36b-fb680dcb4c5d
Khaleva, Ekaterina
0143fad8-e8b7-4286-997b-368a23488ca8
Venter, Carina
a9b7dd5e-b0cb-4068-be82-e15b587cc20b
van Ree, Ronald
f6c2aabb-0e67-4e24-b2ed-b9c30641aebc
Worm, Margitta
59406574-ce5f-4ca5-9319-7543c719cc5b
Vlieg-Boerstra, Berber
9f32bd46-208f-4330-9751-5d19d9b6631b
Sheikh, Aziz
5b7eb24b-0820-4bd6-8304-cc46bbe561a8
Muraro, Antonella
c554bef5-502b-4540-a6f0-a3f7c37f0075
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Nwaru, Bright I.
d49dbf02-337c-4800-92d4-3fe290698e21
Spolidoro, Giulia C.I.
e43ddf6b-a83e-43b0-8eeb-fc7ef25d7e5e
Nyassi, Sungkutu
dfb4ac84-a174-4fe7-aa7c-7b2ada500443
Lisik, Daniil
97db115a-4f08-4768-b304-e12b95002781
Ioannidou, Athina
af08924d-bc9e-4d67-aded-3d54f4ac617d
Ali, Mohamed Mustafa
2c8ea880-4cad-4475-af0f-02d691680f8f
Amera, Yohannes Tesfaye
c1e9e638-ebb4-484d-86dd-e85b717e79a0
Rovner, Graciela
8a8bf134-4f54-4ad7-a36b-fb680dcb4c5d
Khaleva, Ekaterina
0143fad8-e8b7-4286-997b-368a23488ca8
Venter, Carina
a9b7dd5e-b0cb-4068-be82-e15b587cc20b
van Ree, Ronald
f6c2aabb-0e67-4e24-b2ed-b9c30641aebc
Worm, Margitta
59406574-ce5f-4ca5-9319-7543c719cc5b
Vlieg-Boerstra, Berber
9f32bd46-208f-4330-9751-5d19d9b6631b
Sheikh, Aziz
5b7eb24b-0820-4bd6-8304-cc46bbe561a8
Muraro, Antonella
c554bef5-502b-4540-a6f0-a3f7c37f0075
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Nwaru, Bright I.
d49dbf02-337c-4800-92d4-3fe290698e21

Spolidoro, Giulia C.I., Nyassi, Sungkutu, Lisik, Daniil, Ioannidou, Athina, Ali, Mohamed Mustafa, Amera, Yohannes Tesfaye, Rovner, Graciela, Khaleva, Ekaterina, Venter, Carina, van Ree, Ronald, Worm, Margitta, Vlieg-Boerstra, Berber, Sheikh, Aziz, Muraro, Antonella, Roberts, Graham and Nwaru, Bright I. (2024) Food allergy outside the eight big foods in Europe: A systematic review and meta-analysis. Clinical and Translational Allergy, 14 (2), [e12338]. (doi:10.1002/clt2.12338).

Record type: Review

Abstract

Background: The 2014 estimates of prevalence of food allergy (FA) in Europe published by the European Academy of Allergy and Clinical Immunology included only the eight so-called big foods (cow's milk/egg/wheat/soy/peanut/tree nuts/fish/shellfish). Those estimates have recently been updated. Complementing this, we sought to identify and estimate the prevalence of allergy to other foods that have been reported during the last decade. Methods: Six databases were searched for studies published 2012–2021. Random-effects meta-analysis was performed to derive pooled prevalence of allergy to each food. Results: Twenty-seven studies were included, containing a total of 66 FAs. Among the most frequently reported FAs, the lifetime and point prevalence range of self-reported kiwi allergy was 0.1%–1.0% and 0.2%–8.1%, respectively, while the food challenge (FC)-verified kiwi allergy point prevalence range was 0.01%–0.10%. The point prevalence range for self-reported peach allergy was 0.2%–3.2%, while the range for FC-verified peach allergy was 0.02%–0.05%. The lifetime and point prevalence range for self-reported tomato allergy was 0.01%–1.8% and 0.2%–2.1%, respectively. Conclusion: Allergy to some foods traditionally not considered important are now emerging as relevant FAs. The focus on FA in Europe should not be limited to the so-called eight big FA, but extended to other types of foods which need to be considered both for clinical purposes and population risk assessment.

Text
Clinical Translational All - 2024 - Spolidoro - Food allergy outside the eight big foods in Europe A systematic review - Version of Record
Available under License Creative Commons Attribution.
Download (3MB)

More information

Accepted/In Press date: 24 January 2024
Published date: 7 February 2024
Additional Information: Funding Information: The study was funded through an unrestricted grant from DBV Technologies SA. The funders had no influence on the design of the study, interpretation of findings, or the decision to publish. BN acknowledges the support of Knut and Alice Wallenberg Foundation, the Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Sweden, and the VBG Group Herman Krefting Foundation on Asthma and Allergy. Funding Information: Carina Venter reports grants (Reckitt Benckiser, Food Allergy Research and Education, and National Peanut Board) and personal fees (Reckitt Benckiser, Nestle Nutrition Institute, Danone, Abbott Nutrition, Else Nutrition, Sifter, and Before Brands). Ronald van Ree reports consultancies (HAL Allergy BV, Citeq BV, Angany Inc., Reacta Healthcare Ltd., Mission MightyMe, AB Enzymes, The Protein Brewery, and Unilever India), speaker's fees (HAL Allergy BV, ThermoFisher Scientific, and ALK), and stock options (Angany Inc.). Margitta Worm reports grants and personal fees (Stallergènes, HAL Allergy, Bencard Allergie, Allergopharma, ALK‐Abello, Mylan Germany, Actelion Pharmaceuticals Deutschland, Biotest, AbbVie Deutschland, Lilly Deutschland Aimmune, DBV Technologies SA, Regeneron Pharmaceuticals, Sanofi Aventis, Leo Pharma, Novartis, and Viatris) outside the submitted work and being past WAO co‐chair of the anaphylaxis committee and past chair of the food allergy interest group of EAACI. Berber Vlieg‐Boerstra reports personal and speaker fees (Vinimini, Nestlé, and Nutricia) and grants (Nutricia). Antonella Muraro reports grants and speaker's fees (Aimmune), speaker's fees (DVB Technologies SA, Viatris [Mylan], ALK, and Nestlé), and being a member of the Executive Committee of GA2LEN and past president of EAACI. Graham Roberts reports grants (Asthma UK and National Institutes of Health Research). Bright Nwaru reports unrestricted grants and personal fees from DBV Technologies and AstraZeneca, respectively. Giulia C.I. Spolidoro, Yohannes Tesfaye Amera, Mohamed Mustafa Ali, Sungkutu Nyassi, Daniil Lisik, and Athina Ioannidou report fees from ACT Institutet Sweden. The other authors report no conflicting interests related to this work. The funder played no role in the content and decision to submit this manuscript. Publisher Copyright: © 2024 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.
Keywords: epidemiology, Europe, food allergy, sensitization, systematic review

Identifiers

Local EPrints ID: 487641
URI: http://eprints.soton.ac.uk/id/eprint/487641
ISSN: 2045-7022
PURE UUID: 90cf9cd0-3569-477f-9f0b-90a85714aabf
ORCID for Ekaterina Khaleva: ORCID iD orcid.org/0000-0002-2220-7745
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

Catalogue record

Date deposited: 29 Feb 2024 17:55
Last modified: 18 Mar 2024 03:57

Export record

Altmetrics

Contributors

Author: Giulia C.I. Spolidoro
Author: Sungkutu Nyassi
Author: Daniil Lisik
Author: Athina Ioannidou
Author: Mohamed Mustafa Ali
Author: Yohannes Tesfaye Amera
Author: Graciela Rovner
Author: Ekaterina Khaleva ORCID iD
Author: Carina Venter
Author: Ronald van Ree
Author: Margitta Worm
Author: Berber Vlieg-Boerstra
Author: Aziz Sheikh
Author: Antonella Muraro
Author: Graham Roberts ORCID iD
Author: Bright I. Nwaru

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×