Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis
Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis
INTRODUCTION: Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances.
METHODS: Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI).
RESULTS: Forty-nine studies were eligible for this review including a total of 1792 people with CF and 1675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: -0.66, 95% CI -1.14 to -0.17) and E (SMD: -0.74, 95% CI: -1.28 to -0.20), β-carotene (SMD: -1.80, 95% CI: -2.92 to -0.67), lutein (SMD: -1.52, 95% CI: -1.83 to -1.20) and albumin (SMD: -0.98, 95% CI: -1.68 to -0.27) were significantly lower in the plasma or serum of people with CF versus controls.
CONCLUSIONS: This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.
Antioxidants, Biomarkers/metabolism, Cystic Fibrosis, Humans, Oxidative Stress, Vitamins
101436
Causer, Adam J
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Shute, Janis K
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Cummings, Michael H
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Shepherd, Anthony I
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Gruet, Mathieu
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Costello, Joseph T
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Bailey, Stephen
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Lindley, Martin
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Pearson, Clare
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Connett, Gary
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Allenby, Mark I
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Carroll, Mary P
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Daniels, Thomas
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Saynor, Zoe L
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29 May 2020
Causer, Adam J
17d4182a-d52f-4b92-89fc-99cec813e98d
Shute, Janis K
a5eef853-50ae-4abf-9e34-1c873601437f
Cummings, Michael H
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Shepherd, Anthony I
f7073e22-cda6-4816-a4b4-f6246e1aa42e
Gruet, Mathieu
a09718f2-2740-48dd-bf6a-ab16ad65be0d
Costello, Joseph T
3e2f06e7-3948-4d98-acbc-4b181b07a04f
Bailey, Stephen
243fbad7-e2ab-457a-b85f-c5b972767af5
Lindley, Martin
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Pearson, Clare
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Connett, Gary
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Allenby, Mark I
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Carroll, Mary P
b836d262-6b07-4006-9c81-26653a26588b
Daniels, Thomas
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Saynor, Zoe L
a4357c7d-db59-4fa5-b24f-58d2f7e74e39
Causer, Adam J, Shute, Janis K, Cummings, Michael H, Shepherd, Anthony I, Gruet, Mathieu, Costello, Joseph T, Bailey, Stephen, Lindley, Martin, Pearson, Clare, Connett, Gary, Allenby, Mark I, Carroll, Mary P, Daniels, Thomas and Saynor, Zoe L
(2020)
Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis.
Redox Biology, 32, .
(doi:10.1016/j.redox.2020.101436).
Abstract
INTRODUCTION: Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances.
METHODS: Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI).
RESULTS: Forty-nine studies were eligible for this review including a total of 1792 people with CF and 1675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: -0.66, 95% CI -1.14 to -0.17) and E (SMD: -0.74, 95% CI: -1.28 to -0.20), β-carotene (SMD: -1.80, 95% CI: -2.92 to -0.67), lutein (SMD: -1.52, 95% CI: -1.83 to -1.20) and albumin (SMD: -0.98, 95% CI: -1.68 to -0.27) were significantly lower in the plasma or serum of people with CF versus controls.
CONCLUSIONS: This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.
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Accepted/In Press date: 16 January 2020
Published date: 29 May 2020
Additional Information:
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
Keywords:
Antioxidants, Biomarkers/metabolism, Cystic Fibrosis, Humans, Oxidative Stress, Vitamins
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Local EPrints ID: 487793
URI: http://eprints.soton.ac.uk/id/eprint/487793
ISSN: 2213-2317
PURE UUID: 793fb104-8a9c-4686-9ba4-ebe12cb01829
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Date deposited: 05 Mar 2024 18:15
Last modified: 29 Aug 2024 02:09
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Author:
Adam J Causer
Author:
Janis K Shute
Author:
Michael H Cummings
Author:
Anthony I Shepherd
Author:
Mathieu Gruet
Author:
Joseph T Costello
Author:
Stephen Bailey
Author:
Martin Lindley
Author:
Clare Pearson
Author:
Gary Connett
Author:
Mark I Allenby
Author:
Mary P Carroll
Author:
Thomas Daniels
Author:
Zoe L Saynor
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