Maternal mood, anxiety and mental health functioning after combined myo-inositol, probiotics, micronutrient supplementation from preconception: findings from the NiPPeR RCT
Maternal mood, anxiety and mental health functioning after combined myo-inositol, probiotics, micronutrient supplementation from preconception: findings from the NiPPeR RCT
Observational studies have reported associations between nutrition during pregnancy and mental wellbeing. As secondary outcomes, the NiPPeR double-blind randomized trial in women planning conception investigated whether a myo-inositol, probiotics and enriched micronutrients formulation (intervention) taken preconception and throughout pregnancy could improve mental wellbeing during pregnancy and post-delivery, compared with a standard micronutrient supplement (control). Mood and anxiety symptoms were ascertained (Edinburgh Postnatal Depression Scale (EPDS), State-Trait Anxiety Inventory (STAI-state)) at preconception (baseline), 7, 28 and 34 weeks gestation, 3-weeks and 6-months post-delivery. EPDS>=13 was categorised as low mood; STAI-state>=45 as high anxiety. Change in mental health functioning was assessed as difference between preconception baseline and 6-month post-delivery 12-item Short-Form Health Survey (SF-12v2) mental component scores. Adjusting for site, ethnicity and baseline scores, there were no robust differences in EPDS and STAI-state scores between intervention and control groups across pregnancy (n = 630) and post-delivery (n = 532). Compared to controls, intervention group women averaged a 1.21 (95 %CI 0.04,2.39) higher change in SF-12v2 mental component score from preconception to 6-months post-delivery. Taking a myo-inositol, micronutrient and probiotic supplement during preconception/pregnancy had no effect on mood and anxiety, but there was evidence of a modest improvement in mental health functioning from preconception to 6-months post-delivery.
Maternal anxiety, Maternal mood, Mental health functioning, Nutrition, Pregnancy
115813
El-Heis, Sarah
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Barton, Sheila J.
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Chang, Hsin Fang
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Nield, Heidi
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Cox, Vanessa
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Galani, Sevasti
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Cutfield, Wayne
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Chan, Shiao-Yng
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Godfrey, Keith M.
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April 2024
El-Heis, Sarah
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Barton, Sheila J.
4f674382-ca0b-44ad-9670-e71a0b134ef0
Chang, Hsin Fang
9f48c38b-61eb-4843-b0d5-e18dedf7db02
Nield, Heidi
837b180c-0a9e-49ba-bc2e-a899ef761d34
Cox, Vanessa
0edb4291-8b30-4914-9918-841268605d21
Galani, Sevasti
c6258fe5-20b6-40aa-b616-be72a302e2a5
Cutfield, Wayne
046e701e-d524-41f2-b8e5-c2d52fc09c54
Chan, Shiao-Yng
3c9d8970-2cc4-430a-86a7-96f6029a5293
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
El-Heis, Sarah, Barton, Sheila J., Chang, Hsin Fang, Nield, Heidi, Cox, Vanessa, Galani, Sevasti, Cutfield, Wayne, Chan, Shiao-Yng and Godfrey, Keith M.
,
NiPPeR Study Group
(2024)
Maternal mood, anxiety and mental health functioning after combined myo-inositol, probiotics, micronutrient supplementation from preconception: findings from the NiPPeR RCT.
Psychiatry Research, 334, , [115813].
(doi:10.1016/j.psychres.2024.115813).
Abstract
Observational studies have reported associations between nutrition during pregnancy and mental wellbeing. As secondary outcomes, the NiPPeR double-blind randomized trial in women planning conception investigated whether a myo-inositol, probiotics and enriched micronutrients formulation (intervention) taken preconception and throughout pregnancy could improve mental wellbeing during pregnancy and post-delivery, compared with a standard micronutrient supplement (control). Mood and anxiety symptoms were ascertained (Edinburgh Postnatal Depression Scale (EPDS), State-Trait Anxiety Inventory (STAI-state)) at preconception (baseline), 7, 28 and 34 weeks gestation, 3-weeks and 6-months post-delivery. EPDS>=13 was categorised as low mood; STAI-state>=45 as high anxiety. Change in mental health functioning was assessed as difference between preconception baseline and 6-month post-delivery 12-item Short-Form Health Survey (SF-12v2) mental component scores. Adjusting for site, ethnicity and baseline scores, there were no robust differences in EPDS and STAI-state scores between intervention and control groups across pregnancy (n = 630) and post-delivery (n = 532). Compared to controls, intervention group women averaged a 1.21 (95 %CI 0.04,2.39) higher change in SF-12v2 mental component score from preconception to 6-months post-delivery. Taking a myo-inositol, micronutrient and probiotic supplement during preconception/pregnancy had no effect on mood and anxiety, but there was evidence of a modest improvement in mental health functioning from preconception to 6-months post-delivery.
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Accepted/In Press date: 22 February 2024
e-pub ahead of print date: 23 February 2024
Published date: April 2024
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© 2024
Keywords:
Maternal anxiety, Maternal mood, Mental health functioning, Nutrition, Pregnancy
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Local EPrints ID: 487843
URI: http://eprints.soton.ac.uk/id/eprint/487843
ISSN: 0165-1781
PURE UUID: ceba92f5-4917-4e17-9f76-01aeaa3ac369
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Date deposited: 06 Mar 2024 17:43
Last modified: 17 Aug 2024 01:47
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Contributors
Author:
Sarah El-Heis
Author:
Hsin Fang Chang
Author:
Heidi Nield
Author:
Vanessa Cox
Author:
Sevasti Galani
Author:
Wayne Cutfield
Author:
Shiao-Yng Chan
Corporate Author: NiPPeR Study Group
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