Autoregulation of bacterial gene expression: lessons from the MazEF toxin-antitoxin system
Autoregulation of bacterial gene expression: lessons from the MazEF toxin-antitoxin system
Autoregulation is the direct modulation of gene expression by the product of the corresponding gene. Autoregulation of bacterial gene expression has been mostly studied at the transcriptional level, when a protein acts as the cognate transcriptional repressor. A recent study investigating dynamics of the bacterial toxin-antitoxin MazEF system has shown how autoregulation at both the transcriptional and post-transcriptional levels affects the heterogeneity of Escherichia coli populations. Toxin-antitoxin systems hold a crucial but still elusive part in bacterial response to stress. This perspective highlights how these modules can also serve as a great model system for investigating basic concepts in gene regulation. However, as the genomic background and environmental conditions substantially influence toxin activation, it is important to study (auto)regulation of toxin-antitoxin systems in well-defined setups as well as in conditions that resemble the environmental niche.
Bacteria/genetics, Bacterial Proteins/genetics, Bacterial Toxins/genetics, DNA-Binding Proteins/genetics, Endoribonucleases/genetics, Escherichia coli/genetics, Escherichia coli Proteins/genetics, Gene Expression Regulation, Bacterial, Homeostasis/genetics, Toxin-Antitoxin Systems/genetics
133-138
Nikolic, Nela
88a8f576-d9e2-4eb6-9219-39b7065963d3
1 February 2019
Nikolic, Nela
88a8f576-d9e2-4eb6-9219-39b7065963d3
Nikolic, Nela
(2019)
Autoregulation of bacterial gene expression: lessons from the MazEF toxin-antitoxin system.
Current Genetics, 65 (1), .
(doi:10.1007/s00294-018-0879-8).
Abstract
Autoregulation is the direct modulation of gene expression by the product of the corresponding gene. Autoregulation of bacterial gene expression has been mostly studied at the transcriptional level, when a protein acts as the cognate transcriptional repressor. A recent study investigating dynamics of the bacterial toxin-antitoxin MazEF system has shown how autoregulation at both the transcriptional and post-transcriptional levels affects the heterogeneity of Escherichia coli populations. Toxin-antitoxin systems hold a crucial but still elusive part in bacterial response to stress. This perspective highlights how these modules can also serve as a great model system for investigating basic concepts in gene regulation. However, as the genomic background and environmental conditions substantially influence toxin activation, it is important to study (auto)regulation of toxin-antitoxin systems in well-defined setups as well as in conditions that resemble the environmental niche.
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e-pub ahead of print date: 21 August 2018
Published date: 1 February 2019
Keywords:
Bacteria/genetics, Bacterial Proteins/genetics, Bacterial Toxins/genetics, DNA-Binding Proteins/genetics, Endoribonucleases/genetics, Escherichia coli/genetics, Escherichia coli Proteins/genetics, Gene Expression Regulation, Bacterial, Homeostasis/genetics, Toxin-Antitoxin Systems/genetics
Identifiers
Local EPrints ID: 488035
URI: http://eprints.soton.ac.uk/id/eprint/488035
ISSN: 0172-8083
PURE UUID: aca59a9b-7aa6-4c2d-ade0-ba561828ddcc
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Date deposited: 12 Mar 2024 18:23
Last modified: 18 Mar 2024 04:18
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Author:
Nela Nikolic
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