READ ME File For 'Identification and development of cyclic peptide inhibitors of Hypoxia Inducible Factors 1 and 2 that disrupt hypoxia-response signaling in cancer cells'

Dataset DOI: 10.5258/SOTON/D2988

Date that the file was created: March, 2024

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GENERAL INFORMATION
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ReadMe Author: Ali Tavassoli, University of Southampton

Date of data collection: 2010-2024

Information about geographic location of data collection: University of Southampton, University, UK

Related projects: N/A


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SHARING/ACCESS INFORMATION
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Licenses/restrictions placed on the data, or limitations of reuse:

Recommended citation for the data:

This dataset supports the publication:
AUTHORS: Andrew T. Ball, Soran Mohammed, Cyrielle Doigneaux, Reece M. Gardner, James W. Easton, Steven Turner, Jonathan W. Essex, Garry Pairaudeau, and Ali Tavassoli
TITLE: Identification and development of cyclic peptide inhibitors of Hypoxia Inducible Factors 1 and 2 that disrupt hypoxia-response signaling in cancer cells
JOURNAL: Journal of the American Chemical Society
PAPER DOI: https://doi.org/10.1021/jacs.3c10508


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DATA & FILE OVERVIEW
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This dataset contains data for the following:

Figure 1d - raw data in Graphpad Prism format
Figure 2a - raw data in Graphpad Prism format
Figure 2b - raw data in Graphpad Prism format
Figure 3a - raw data in Graphpad Prism format
Figure 3d - raw data in Graphpad Prism format
Figure 5d - raw data in Graphpad Prism format
Figure 5e - raw data in Graphpad Prism format
Figure 6a - raw data in Graphpad Prism format
Figure 6b - raw data in Graphpad Prism format
Figure 6d - uncropped gel images from Western blots
Figure 6e - raw data in Graphpad Prism format
Figure 6f - raw data in Graphpad Prism format
Figure S2 - raw data in Graphpad Prism format
Figure S3b - raw data in Graphpad Prism format
Figure S3c - raw data in Graphpad Prism format
Figure S3d - raw data in Graphpad Prism format
Figure S5a - raw data in Graphpad Prism format
Figure S5b - raw data in Graphpad Prism format
Figure S5c - raw data in Graphpad Prism format
Figure S6a-o - raw data in Graphpad Prism format
Figure S7a-g - raw data in Graphpad Prism format
Figure S8a - raw data in Graphpad Prism format
Figure S8b - raw data in Graphpad Prism format
Figure S9 - raw data in Graphpad Prism format



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METHODOLOGICAL INFORMATION
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Description of methods used for collection/generation of data: detailed in the manuscript and its experimental section.

Methods for processing the data: KDs determined using Graphed Prism

Software- or Instrument-specific information needed to interpret the data, including software and hardware version numbers: Graphed Prism 9

People involved with sample collection, processing, analysis and/or submission: Andrew T. Ball, Soran Mohammed, Cyrielle Doigneaux, Reece M. Gardner,