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Population differences in the international multi-centre ADHD gene project

Population differences in the international multi-centre ADHD gene project
Population differences in the international multi-centre ADHD gene project
The International Multi-Centre ADHD Gene sample consists of 674 families from eight countries (Belgium, England, Germany, Holland, Ireland, Israel, Spain, and Switzerland) ascertained from clinics for combined-type attention definity hyperactivity disorder in an offspring. 863 SNPs were successfully genotyped across 47 autosomal genes implicated in psychiatric disorders yielding a single nucleotide polymorphism (SNP) density of approximately one SNP per 2.5 kb. A global test of heterogeneity showed 269 SNPs nominally significant (expected 43). Inclusion of the Israeli population accounted for approximately 70% of these nominally significant tests. Hardy-Weinberg equilibrium tests suggest that combining all these populations would induce stratification, but that the Northern European populations (Belgium, England, Germany, Holland, and Ireland) could be appropriate. Tag SNPs were generated using pair-wise and aggressive tagging from Carlson et al. [[2004]] and de Bakker et al. [[2005]], respectively, in each population and applied to the other populations. Cross-population performance across Northern Europe was consistent with within population comparisons. Smaller sample size for each population tended to yield more problems for the generation of aggressive tags and the application of pair-wise tags. Any case-control sample employing an Israeli sample with Northern Europeans must consider stratification. A Northern European tag set, however, appears to be appropriate for capturing the variation across populations.
linkage disequilibrium, tagging, hapMap
0741-0395
98-107
Neale, B.M.
7c89a4c3-7b53-4fa2-9e35-e4a220bcb28f
Sham, P.C.
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Purcell, S.
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Banaschewski, T.
ca2651e5-143a-4171-b6d0-3e3853b684d8
Buitelaar, J.
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Franke, B.
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Sonuga-Barke, E.
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Ebstein, R.
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Eisenberg, J.
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Mulligan, A.
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Gill, M.
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Manor, I.
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Miranda, A.
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Mulas, F.
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Oades, R.D.
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Roeyers, H.
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Rothenberger, A.
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Sergeant, J.
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Steinhausen, H.C.
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Taylor, E.
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Thompson, M.
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Zhou, K.
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Asherson, P.
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Faraone, S.V.
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Neale, B.M.
7c89a4c3-7b53-4fa2-9e35-e4a220bcb28f
Sham, P.C.
d7e95eb6-0b71-4eb8-a3ef-68cdc2cb2624
Purcell, S.
81845cac-5481-4791-b184-a2c5fd1272c3
Banaschewski, T.
ca2651e5-143a-4171-b6d0-3e3853b684d8
Buitelaar, J.
fa22aba5-1307-4627-9ae8-e564013a5af8
Franke, B.
d3276e6a-292a-489d-b589-de3af1b0162d
Sonuga-Barke, E.
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Ebstein, R.
451c2126-5196-41ff-81f9-490a200398e9
Eisenberg, J.
d91585a2-2d07-45b3-85e1-53b1ef09c0ea
Mulligan, A.
4d845804-c87e-4ac3-9da2-25cce7e7ead5
Gill, M.
ae2696a2-c4b5-4a68-8f42-f26dbed5e251
Manor, I.
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Miranda, A.
8aa5d3d9-71b4-4498-b369-9fba532f5d4e
Mulas, F.
44612276-b250-4f01-97b3-46e115f49a25
Oades, R.D.
89c5ac77-d90a-4d61-8cd0-826e4c90441c
Roeyers, H.
c97b7f56-f514-44cb-b7e2-545c68583d6e
Rothenberger, A.
f946fbda-7ceb-46b0-b48d-23cdaa4016aa
Sergeant, J.
76cfd9c5-bab9-4119-b5c2-af1749e22c71
Steinhausen, H.C.
dfa222f6-e520-4916-b628-d74ddda5c80f
Taylor, E.
4528abc7-ae2b-4268-a646-68f9c2cae4d3
Thompson, M.
bfe8522c-b252-4771-8036-744e93357c67
Zhou, K.
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Asherson, P.
4ecfa0c9-ea9c-47b9-aae8-429822c6c7ee
Faraone, S.V.
023439f0-0461-4037-9b79-27e0c25a9488

Neale, B.M., Sham, P.C., Purcell, S., Banaschewski, T., Buitelaar, J., Franke, B., Sonuga-Barke, E., Ebstein, R., Eisenberg, J., Mulligan, A., Gill, M., Manor, I., Miranda, A., Mulas, F., Oades, R.D., Roeyers, H., Rothenberger, A., Sergeant, J., Steinhausen, H.C., Taylor, E., Thompson, M., Zhou, K., Asherson, P. and Faraone, S.V. (2008) Population differences in the international multi-centre ADHD gene project Genetic Epidemiology, 32, (2), pp. 98-107. (doi:10.1002/gepi.20265).

Record type: Article

Abstract

The International Multi-Centre ADHD Gene sample consists of 674 families from eight countries (Belgium, England, Germany, Holland, Ireland, Israel, Spain, and Switzerland) ascertained from clinics for combined-type attention definity hyperactivity disorder in an offspring. 863 SNPs were successfully genotyped across 47 autosomal genes implicated in psychiatric disorders yielding a single nucleotide polymorphism (SNP) density of approximately one SNP per 2.5 kb. A global test of heterogeneity showed 269 SNPs nominally significant (expected 43). Inclusion of the Israeli population accounted for approximately 70% of these nominally significant tests. Hardy-Weinberg equilibrium tests suggest that combining all these populations would induce stratification, but that the Northern European populations (Belgium, England, Germany, Holland, and Ireland) could be appropriate. Tag SNPs were generated using pair-wise and aggressive tagging from Carlson et al. [[2004]] and de Bakker et al. [[2005]], respectively, in each population and applied to the other populations. Cross-population performance across Northern Europe was consistent with within population comparisons. Smaller sample size for each population tended to yield more problems for the generation of aggressive tags and the application of pair-wise tags. Any case-control sample employing an Israeli sample with Northern Europeans must consider stratification. A Northern European tag set, however, appears to be appropriate for capturing the variation across populations.

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More information

Published date: 2008
Keywords: linkage disequilibrium, tagging, hapMap

Identifiers

Local EPrints ID: 48824
URI: http://eprints.soton.ac.uk/id/eprint/48824
ISSN: 0741-0395
PURE UUID: 1a99a112-51e5-4d2a-b2bf-5d9e652751a2

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Date deposited: 17 Oct 2007
Last modified: 17 Jul 2017 14:58

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Contributors

Author: B.M. Neale
Author: P.C. Sham
Author: S. Purcell
Author: T. Banaschewski
Author: J. Buitelaar
Author: B. Franke
Author: E. Sonuga-Barke
Author: R. Ebstein
Author: J. Eisenberg
Author: A. Mulligan
Author: M. Gill
Author: I. Manor
Author: A. Miranda
Author: F. Mulas
Author: R.D. Oades
Author: H. Roeyers
Author: A. Rothenberger
Author: J. Sergeant
Author: H.C. Steinhausen
Author: E. Taylor
Author: M. Thompson
Author: K. Zhou
Author: P. Asherson
Author: S.V. Faraone

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