4D bioprinting of smart polymers for biomedical applications: recent progress, challenges, and future perspectives
4D bioprinting of smart polymers for biomedical applications: recent progress, challenges, and future perspectives
4D bioprinting is the next-generation additive manufacturing-based fabrication platform employed to construct intricate, adaptive, and dynamic soft and hard tissue structures as well as biomedical devices. It is achieved by using stimuli-responsive materials, especially shape memory polymers (SMPs) and hydrogels, which possess desirable biomechanical characteristics. In the last few years, numerous efforts have been made by 4D printing community to develop novel stimuli-responsive polymeric materials by considering their biomedical perspective. This review presents an up-to-date overview of 4D bioprinting technology incorporating bioprinting materials, functionalities of biomaterials as well as the focused approach towards different tissue engineering and regenerative medicine (TERM) applications. It includes bone, cardiac, neural, cartilage, drug delivery systems, and other high-value biomedical devices. This review also addresses current limitations and challenges in 4D bioprinting technology to provide a basis for foreseeable advancements for TERM applications that could be helpful for their successful utilization in clinical settings.
4D printing, Biomedical applications, Hydrogels, Scaffolds, Shape memory polymers, Tissue engineering
Arif, Zia Ullah
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Khalid, Muhammad Yasir
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Zolfagharian, Ali
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Bodaghi, Mahdi
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Arif, Zia Ullah
49914102-f4f6-417f-9881-22a80015dedf
Khalid, Muhammad Yasir
156549c9-dd36-42d8-a9d1-8118a3286d3f
Zolfagharian, Ali
e131ad99-f88e-4297-84c6-9fea2beb891f
Bodaghi, Mahdi
3f0e3afe-4253-4a53-847b-03fb4e85bf14
Arif, Zia Ullah, Khalid, Muhammad Yasir, Zolfagharian, Ali and Bodaghi, Mahdi
(2022)
4D bioprinting of smart polymers for biomedical applications: recent progress, challenges, and future perspectives.
Reactive and Functional Polymers, 179, [105374].
(doi:10.1016/j.reactfunctpolym.2022.105374).
Abstract
4D bioprinting is the next-generation additive manufacturing-based fabrication platform employed to construct intricate, adaptive, and dynamic soft and hard tissue structures as well as biomedical devices. It is achieved by using stimuli-responsive materials, especially shape memory polymers (SMPs) and hydrogels, which possess desirable biomechanical characteristics. In the last few years, numerous efforts have been made by 4D printing community to develop novel stimuli-responsive polymeric materials by considering their biomedical perspective. This review presents an up-to-date overview of 4D bioprinting technology incorporating bioprinting materials, functionalities of biomaterials as well as the focused approach towards different tissue engineering and regenerative medicine (TERM) applications. It includes bone, cardiac, neural, cartilage, drug delivery systems, and other high-value biomedical devices. This review also addresses current limitations and challenges in 4D bioprinting technology to provide a basis for foreseeable advancements for TERM applications that could be helpful for their successful utilization in clinical settings.
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Accepted/In Press date: 5 August 2022
e-pub ahead of print date: 10 August 2022
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© 2022 The Authors
Keywords:
4D printing, Biomedical applications, Hydrogels, Scaffolds, Shape memory polymers, Tissue engineering
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Local EPrints ID: 488305
URI: http://eprints.soton.ac.uk/id/eprint/488305
ISSN: 1381-5148
PURE UUID: 3ba44602-7c1d-4b3e-a91b-b967bf98ad68
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Date deposited: 19 Mar 2024 18:13
Last modified: 21 Mar 2024 03:13
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Author:
Zia Ullah Arif
Author:
Muhammad Yasir Khalid
Author:
Ali Zolfagharian
Author:
Mahdi Bodaghi
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