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7.13-Biosynthesis of heme and vitamin B12

7.13-Biosynthesis of heme and vitamin B12
7.13-Biosynthesis of heme and vitamin B12
The biosyntheses of the modified tetrapyrroles heme and adenosylcobalamin are outlined. The two compounds are made via a branched biosynthetic pathway that forks at the first macrocyclic intermediate uroporphyrinogen III. For heme synthesis, modification of the peripheral acetate and propionate side chains, oxidation, and ferrochelation yields heme. In contrast, an extensive program of peripheral methylation, cobalt insertion, side chain amidation, ring contraction, decarboxylation, and the attachment of upper and lower axial ligands for the cobalt ion are required for cobalamin synthesis. This review outlines the individual steps in molecular detail and reflects on the range of different chemistries and enzymes that are involved in making these two essential metalloprosthetic groups.
445-499
Elsevier Ltd.
Layer, Gunhild
ce71fc50-4b09-49a6-a76a-512a18d74a71
Jahn, Dieter
68cd66df-4904-4a65-9377-d5708713b992
Deery, Evelyne
16c10c8d-1383-4ce6-95dd-dfcfa0168875
Lawrence, Andrew D.
ce503b40-0155-486f-bb1d-26830b61b5f1
Warren, Martin J.
938c8111-bfc4-4e89-989b-a2a357b00f1e
Hung-Wen, Liu (Ben)
Mander, Lew
Layer, Gunhild
ce71fc50-4b09-49a6-a76a-512a18d74a71
Jahn, Dieter
68cd66df-4904-4a65-9377-d5708713b992
Deery, Evelyne
16c10c8d-1383-4ce6-95dd-dfcfa0168875
Lawrence, Andrew D.
ce503b40-0155-486f-bb1d-26830b61b5f1
Warren, Martin J.
938c8111-bfc4-4e89-989b-a2a357b00f1e
Hung-Wen, Liu (Ben)
Mander, Lew

Layer, Gunhild, Jahn, Dieter, Deery, Evelyne, Lawrence, Andrew D. and Warren, Martin J. (2010) 7.13-Biosynthesis of heme and vitamin B12. In, Hung-Wen, Liu (Ben) and Mander, Lew (eds.) Comprehensive Natural Products II. Elsevier Ltd., pp. 445-499. (doi:10.1016/b978-008045382-8.00144-1).

Record type: Book Section

Abstract

The biosyntheses of the modified tetrapyrroles heme and adenosylcobalamin are outlined. The two compounds are made via a branched biosynthetic pathway that forks at the first macrocyclic intermediate uroporphyrinogen III. For heme synthesis, modification of the peripheral acetate and propionate side chains, oxidation, and ferrochelation yields heme. In contrast, an extensive program of peripheral methylation, cobalt insertion, side chain amidation, ring contraction, decarboxylation, and the attachment of upper and lower axial ligands for the cobalt ion are required for cobalamin synthesis. This review outlines the individual steps in molecular detail and reflects on the range of different chemistries and enzymes that are involved in making these two essential metalloprosthetic groups.

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e-pub ahead of print date: 17 March 2010

Identifiers

Local EPrints ID: 488321
URI: http://eprints.soton.ac.uk/id/eprint/488321
PURE UUID: 1a7ba85c-3f0d-42a0-8e13-0730c66d7114
ORCID for Andrew D. Lawrence: ORCID iD orcid.org/0000-0002-5853-5409

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Date deposited: 20 Mar 2024 17:46
Last modified: 21 Mar 2024 03:11

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Contributors

Author: Gunhild Layer
Author: Dieter Jahn
Author: Evelyne Deery
Author: Andrew D. Lawrence ORCID iD
Author: Martin J. Warren
Editor: Liu (Ben) Hung-Wen
Editor: Lew Mander

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