3D and 4D bioprinting technologies: a game changer for the biomedical sector?

Noroozi, Reza, Arif, Zia Ullah, Taghvaei, Hadi, Khalid, Muhammad Yasir, Sahbafar, Hossein, Hadi, Amin, Sadeghianmaryan, Ali and Chen, Xiongbiao (2023) 3D and 4D bioprinting technologies: a game changer for the biomedical sector? Annals of Biomedical Engineering, 51 (8), 1683-1712. (doi:10.1007/s10439-023-03243-9).

Abstract

Bioprinting is an innovative and emerging technology of additive manufacturing (AM) and has revolutionized the biomedical sector by printing three-dimensional (3D) cell-laden constructs in a precise and controlled manner for numerous clinical applications. This approach uses biomaterials and varying types of cells to print constructs for tissue regeneration, e.g., cardiac, bone, corneal, cartilage, neural, and skin. Furthermore, bioprinting technology helps to develop drug delivery and wound healing systems, bio-actuators, bio-robotics, and bio-sensors. More recently, the development of four-dimensional (4D) bioprinting technology and stimuli-responsive materials has transformed the biomedical sector with numerous innovations and revolutions. This issue also leads to the exponential growth of the bioprinting market, with a value over billions of dollars. The present study reviews the concepts and developments of 3D and 4D bioprinting technologies, surveys the applications of these technologies in the biomedical sector, and discusses their potential research topics for future works. It is also urged that collaborative and valiant efforts from clinicians, engineers, scientists, and regulatory bodies are needed for translating this technology into the biomedical, pharmaceutical, and healthcare systems.

This record has no associated files available for download.

Contributors

Author: Zia Ullah Arif

Download statistics