Sustained increase in pediatric inflammatory bowel disease incidence across the South West United Kingdom over the last 10 years
Sustained increase in pediatric inflammatory bowel disease incidence across the South West United Kingdom over the last 10 years
Background: pediatric inflammatory bowel disease (pIBD) incidence has increased over the last 25 years. We aim to report contemporaneous trends across the South West United Kingdom.
Methods: data were provided from centers covering the South West United Kingdom (Bristol, Oxford, Cardiff, Exeter, and Southampton), with a total area at-risk population (<18 years of age) of 2 947 534. Cases were retrieved from 2013 to 2022. Incident rates were reported per 100 000 at-risk population, with temporal trends analyzed through correlation. Subgroup analysis was undertaken for age groups (0-6, 6-11, and 12-17 years of age), sex, and disease subtype. Choropleth maps were created for local districts.
Results: in total, 2497 pIBD cases were diagnosed between 2013 and 2022, with a mean age of 12.6 years (38.7% female). Diagnosis numbers increased from 187 to 376, with corresponding incidence rates of 6.0 per 100 000 population per year (2013) to 12.4 per 100 000 population per year (2022) (b = 0.918, P < .01). Female rates increased from 5.1 per 100 000 population per year in 2013 to 11.0 per 100 000 population per year in 2022 (b = 0.865, P = .01). Male rates increased from 5.7 per 100 000 population per year to 14.4 per 100 000 population per year (b = 0.832, P = .03). Crohn's disease incidence increased from 3.1 per 100 000 population per year to 6.3 per 100 000 population per year (b = 0.897, P < .01). Ulcerative colitis increased from 2.3 per 100 000 population per year to 4.3 per 100 000 population per year (b = 0.813, P = .04). Inflammatory bowel disease unclassified also increased, from 0.6 per 100 000 population per year to 1.8 per 100 000 population per year (b = 0.851, P = .02). Statistically significant increases were seen in those ≥12 to 17 years of age, from 11.2 per 100 000 population per year to 24.6 per 100 000 population per year (b = 0.912, P < .01), and the 7- to 11-year-old age group, with incidence rising from 4.4 per 100 000 population per year to 7.6 per 100 000 population per year (b = 0.878, P = .01). There was no statistically significant increase in very early onset inflammatory bowel disease (≤6 years of age) (b = 0.417, P = .231).
Conclusions: we demonstrate significant increases in pIBD incidence across a large geographical area including multiple referral centers. Increasing incidence has implications for service provision for services managing pIBD.
Colitis, Ulcerative/epidemiology, Crohn Disease/epidemiology, Humans, Child, Preschool, Infant, Male, United Kingdom/epidemiology, Incidence, Inflammatory Bowel Diseases/epidemiology, Adolescent, Female, Child, Infant, Newborn
2271-2279
Green, Zachary
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Ashton, James J.
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Rodrigues, Astor
34c5ba48-f9c0-4abd-887f-24c978fea70a
Spray, Christine
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Howarth, Lucy
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Mallikarjuna, Akshatha
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Chanchlani, Neil
10662c8f-e7d5-41f6-be8a-7a32489546f4
Hart, James
4ba81855-f72b-40ec-85a1-dbde49cedc43
Bakewell, Christopher
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Lee, Kwang Yang
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Wahid, Amar
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Beattie, R. Mark
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19 February 2024
Green, Zachary
927f42a3-e038-493c-b0af-cab62a7f5560
Ashton, James J.
1c0bfa29-794c-4fd5-93e0-6769e6037d72
Rodrigues, Astor
34c5ba48-f9c0-4abd-887f-24c978fea70a
Spray, Christine
4c24abb5-79f0-400f-b465-98b926411d5f
Howarth, Lucy
140f8c76-205b-4e4c-89db-abfd905b2261
Mallikarjuna, Akshatha
29f64822-5d0c-4871-b9e5-3adf2af070bf
Chanchlani, Neil
10662c8f-e7d5-41f6-be8a-7a32489546f4
Hart, James
4ba81855-f72b-40ec-85a1-dbde49cedc43
Bakewell, Christopher
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Lee, Kwang Yang
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Wahid, Amar
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Beattie, R. Mark
9a66af0b-f81c-485c-b01d-519403f0038a
Green, Zachary, Ashton, James J., Rodrigues, Astor, Spray, Christine, Howarth, Lucy, Mallikarjuna, Akshatha, Chanchlani, Neil, Hart, James, Bakewell, Christopher, Lee, Kwang Yang, Wahid, Amar and Beattie, R. Mark
(2024)
Sustained increase in pediatric inflammatory bowel disease incidence across the South West United Kingdom over the last 10 years.
Inflammatory Bowel Diseases, 30 (12), .
(doi:10.1093/ibd/izad302).
Abstract
Background: pediatric inflammatory bowel disease (pIBD) incidence has increased over the last 25 years. We aim to report contemporaneous trends across the South West United Kingdom.
Methods: data were provided from centers covering the South West United Kingdom (Bristol, Oxford, Cardiff, Exeter, and Southampton), with a total area at-risk population (<18 years of age) of 2 947 534. Cases were retrieved from 2013 to 2022. Incident rates were reported per 100 000 at-risk population, with temporal trends analyzed through correlation. Subgroup analysis was undertaken for age groups (0-6, 6-11, and 12-17 years of age), sex, and disease subtype. Choropleth maps were created for local districts.
Results: in total, 2497 pIBD cases were diagnosed between 2013 and 2022, with a mean age of 12.6 years (38.7% female). Diagnosis numbers increased from 187 to 376, with corresponding incidence rates of 6.0 per 100 000 population per year (2013) to 12.4 per 100 000 population per year (2022) (b = 0.918, P < .01). Female rates increased from 5.1 per 100 000 population per year in 2013 to 11.0 per 100 000 population per year in 2022 (b = 0.865, P = .01). Male rates increased from 5.7 per 100 000 population per year to 14.4 per 100 000 population per year (b = 0.832, P = .03). Crohn's disease incidence increased from 3.1 per 100 000 population per year to 6.3 per 100 000 population per year (b = 0.897, P < .01). Ulcerative colitis increased from 2.3 per 100 000 population per year to 4.3 per 100 000 population per year (b = 0.813, P = .04). Inflammatory bowel disease unclassified also increased, from 0.6 per 100 000 population per year to 1.8 per 100 000 population per year (b = 0.851, P = .02). Statistically significant increases were seen in those ≥12 to 17 years of age, from 11.2 per 100 000 population per year to 24.6 per 100 000 population per year (b = 0.912, P < .01), and the 7- to 11-year-old age group, with incidence rising from 4.4 per 100 000 population per year to 7.6 per 100 000 population per year (b = 0.878, P = .01). There was no statistically significant increase in very early onset inflammatory bowel disease (≤6 years of age) (b = 0.417, P = .231).
Conclusions: we demonstrate significant increases in pIBD incidence across a large geographical area including multiple referral centers. Increasing incidence has implications for service provision for services managing pIBD.
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IBD incidence data_01_08_23
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e-pub ahead of print date: 19 February 2024
Published date: 19 February 2024
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Keywords:
Colitis, Ulcerative/epidemiology, Crohn Disease/epidemiology, Humans, Child, Preschool, Infant, Male, United Kingdom/epidemiology, Incidence, Inflammatory Bowel Diseases/epidemiology, Adolescent, Female, Child, Infant, Newborn
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Local EPrints ID: 488521
URI: http://eprints.soton.ac.uk/id/eprint/488521
ISSN: 1536-4844
PURE UUID: 5b7cdb95-4537-4e3b-a1ed-08f318e38cc2
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Date deposited: 26 Mar 2024 17:40
Last modified: 18 Dec 2024 17:57
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Contributors
Author:
Zachary Green
Author:
James J. Ashton
Author:
Astor Rodrigues
Author:
Christine Spray
Author:
Lucy Howarth
Author:
Akshatha Mallikarjuna
Author:
Neil Chanchlani
Author:
James Hart
Author:
Christopher Bakewell
Author:
Kwang Yang Lee
Author:
Amar Wahid
Author:
R. Mark Beattie
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