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Pan-European survey on current treatment strategies in patients with upfront resectable colorectal liver metastases

Pan-European survey on current treatment strategies in patients with upfront resectable colorectal liver metastases
Pan-European survey on current treatment strategies in patients with upfront resectable colorectal liver metastases

Background: There is a lack of consensus on the definition of upfront resectability and use of perioperative systemic therapy for colorectal liver metastases (CRLM). This survey aimed to summarize the current treatment strategies for upfront resectable CRLM throughout Europe. Methods: A survey was sent to all members of the European-African Hepato-Pancreato-Biliary Association to gain insight into the current views on resectability and the use of systemic therapy for upfront resectable CRLM. Results: The survey was completed by 87 surgeons from 24 countries. The resectability of CRLM is mostly based on the volume of the future liver remnant, while considering tumor biology. Thermal ablation was considered as an acceptable adjunct to resection in parenchymal-sparing CRLM surgery by 77 % of the respondents. A total of 40.2 % of the respondents preferred standard perioperative systemic therapy and 24.1 % preferred standard upfront local treatment. Conclusion: Among the participating European hepato-pancreato-biliary surgeons, there is a high degree of consensus on the definition of CRLM resectability. However, there is much variety in the use of adjunctive thermal ablation. Major variations persist in the use of perioperative systemic therapy in cases of upfront resectable CRLM, stressing the need for further evidence and a consensus.

1365-182X
639-647
Kuiper, Babette I.
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Abu Hilal, Mohammad
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Aldrighetti, Luca A
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Björnsson, Bergthor
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D'Hondt, Mathieu
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Dopazo, Cristina
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Fretland, Åsmund A.
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Isoniemi, Helena
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Philip Jonas, J.
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Kazemier, Geert
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Lesurtel, Mickael
c02bddad-a09f-4150-aacb-fe42fc518d66
Primrose, John
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Schnitzbauer, Andreas A.
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Buffart, Tineke
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Gruenberger, Birgit
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Swijnenburg, Rutger-Jan
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Gruenberger, Thomas
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Kuiper, Babette I.
965544f9-9a6a-4467-89f4-f605bdf01808
Abu Hilal, Mohammad
384e1c60-8519-4eed-8e92-91775aad4c47
Aldrighetti, Luca A
a4b19d20-4a6e-4b98-9267-f76edcd689a0
Björnsson, Bergthor
fe8fcaf2-bd24-497c-b00a-62f7fc34c2e4
D'Hondt, Mathieu
dad5077e-c50f-45dc-a433-f5e327566bb6
Dopazo, Cristina
a6aff21e-af75-485f-a6a6-c5f65f416ae9
Fretland, Åsmund A.
e1edf2e5-06ee-43eb-b2b3-33ae0ca63ad3
Isoniemi, Helena
ff9ce20c-090f-4c0b-8f7c-c76109f67b2d
Philip Jonas, J.
f03c369a-f452-4600-9a37-16a78ea20731
Kazemier, Geert
33b7bfcd-f883-499d-85ab-6e6af1872a47
Lesurtel, Mickael
c02bddad-a09f-4150-aacb-fe42fc518d66
Primrose, John
d85f3b28-24c6-475f-955b-ec457a3f9185
Schnitzbauer, Andreas A.
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Buffart, Tineke
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Gruenberger, Birgit
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Swijnenburg, Rutger-Jan
2ddfec95-4662-4ff7-8249-c110eabce9a5
Gruenberger, Thomas
3e909c56-b9e9-4a37-a28e-305c41205525

Kuiper, Babette I., Abu Hilal, Mohammad, Aldrighetti, Luca A, Björnsson, Bergthor, D'Hondt, Mathieu, Dopazo, Cristina, Fretland, Åsmund A., Isoniemi, Helena, Philip Jonas, J., Kazemier, Geert, Lesurtel, Mickael, Primrose, John, Schnitzbauer, Andreas A., Buffart, Tineke, Gruenberger, Birgit, Swijnenburg, Rutger-Jan and Gruenberger, Thomas (2024) Pan-European survey on current treatment strategies in patients with upfront resectable colorectal liver metastases. HPB, 26 (5), 639-647. (doi:10.1016/j.hpb.2024.01.007).

Record type: Article

Abstract

Background: There is a lack of consensus on the definition of upfront resectability and use of perioperative systemic therapy for colorectal liver metastases (CRLM). This survey aimed to summarize the current treatment strategies for upfront resectable CRLM throughout Europe. Methods: A survey was sent to all members of the European-African Hepato-Pancreato-Biliary Association to gain insight into the current views on resectability and the use of systemic therapy for upfront resectable CRLM. Results: The survey was completed by 87 surgeons from 24 countries. The resectability of CRLM is mostly based on the volume of the future liver remnant, while considering tumor biology. Thermal ablation was considered as an acceptable adjunct to resection in parenchymal-sparing CRLM surgery by 77 % of the respondents. A total of 40.2 % of the respondents preferred standard perioperative systemic therapy and 24.1 % preferred standard upfront local treatment. Conclusion: Among the participating European hepato-pancreato-biliary surgeons, there is a high degree of consensus on the definition of CRLM resectability. However, there is much variety in the use of adjunctive thermal ablation. Major variations persist in the use of perioperative systemic therapy in cases of upfront resectable CRLM, stressing the need for further evidence and a consensus.

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Accepted/In Press date: 15 January 2024
e-pub ahead of print date: 29 January 2024
Published date: May 2024
Additional Information: Publisher Copyright: © 2024 The Author(s)

Identifiers

Local EPrints ID: 488832
URI: http://eprints.soton.ac.uk/id/eprint/488832
ISSN: 1365-182X
PURE UUID: eafeaefd-5844-4515-a75e-17e6dcc44636
ORCID for John Primrose: ORCID iD orcid.org/0000-0002-2069-7605

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Date deposited: 08 Apr 2024 16:31
Last modified: 30 May 2024 01:33

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Contributors

Author: Babette I. Kuiper
Author: Mohammad Abu Hilal
Author: Luca A Aldrighetti
Author: Bergthor Björnsson
Author: Mathieu D'Hondt
Author: Cristina Dopazo
Author: Åsmund A. Fretland
Author: Helena Isoniemi
Author: J. Philip Jonas
Author: Geert Kazemier
Author: Mickael Lesurtel
Author: John Primrose ORCID iD
Author: Andreas A. Schnitzbauer
Author: Tineke Buffart
Author: Birgit Gruenberger
Author: Rutger-Jan Swijnenburg
Author: Thomas Gruenberger

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