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Attention-deficit/hyperactivity disorder

Attention-deficit/hyperactivity disorder
Attention-deficit/hyperactivity disorder

Attention-deficit/hyperactivity disorder (ADHD; also known as hyperkinetic disorder) is a common neurodevelopmental condition that affects children and adults worldwide. ADHD has a predominantly genetic aetiology that involves common and rare genetic variants. Some environmental correlates of the disorder have been discovered but causation has been difficult to establish. The heterogeneity of the condition is evident in the diverse presentation of symptoms and levels of impairment, the numerous co-occurring mental and physical conditions, the various domains of neurocognitive impairment, and extensive minor structural and functional brain differences. The diagnosis of ADHD is reliable and valid when evaluated with standard diagnostic criteria. Curative treatments for ADHD do not exist but evidence-based treatments substantially reduce symptoms and/or functional impairment. Medications are effective for core symptoms and are usually well tolerated. Some non-pharmacological treatments are valuable, especially for improving adaptive functioning. Clinical and neurobiological research is ongoing and could lead to the creation of personalized diagnostic and therapeutic approaches for this disorder.

Faraone, Stephen V.
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Bellgrove, Mark A.
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Brikell, Isabell
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Cortese, Samuele
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Hartman, Catharina A.
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Hollis, Chris
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Newcorn, Jeffrey H.
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Philipsen, Alexandra
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Polanczyk, Guilherme V.
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Rubia, Katya
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Sibley, Margaret H.
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Buitelaar, Jan K.
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Faraone, Stephen V.
11abe086-d301-4ca2-bbd5-d7a516be924f
Bellgrove, Mark A.
fb883055-1139-4f9f-b22e-5a3c1be5be20
Brikell, Isabell
8ce0666a-d578-4128-9385-20358b875b7c
Cortese, Samuele
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Hartman, Catharina A.
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Hollis, Chris
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Newcorn, Jeffrey H.
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Philipsen, Alexandra
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Polanczyk, Guilherme V.
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Rubia, Katya
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Sibley, Margaret H.
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Buitelaar, Jan K.
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Faraone, Stephen V., Bellgrove, Mark A., Brikell, Isabell, Cortese, Samuele, Hartman, Catharina A., Hollis, Chris, Newcorn, Jeffrey H., Philipsen, Alexandra, Polanczyk, Guilherme V., Rubia, Katya, Sibley, Margaret H. and Buitelaar, Jan K. (2024) Attention-deficit/hyperactivity disorder. Nature Reviews Disease Primers, 10 (1), [11]. (doi:10.1038/s41572-024-00495-0).

Record type: Article

Abstract

Attention-deficit/hyperactivity disorder (ADHD; also known as hyperkinetic disorder) is a common neurodevelopmental condition that affects children and adults worldwide. ADHD has a predominantly genetic aetiology that involves common and rare genetic variants. Some environmental correlates of the disorder have been discovered but causation has been difficult to establish. The heterogeneity of the condition is evident in the diverse presentation of symptoms and levels of impairment, the numerous co-occurring mental and physical conditions, the various domains of neurocognitive impairment, and extensive minor structural and functional brain differences. The diagnosis of ADHD is reliable and valid when evaluated with standard diagnostic criteria. Curative treatments for ADHD do not exist but evidence-based treatments substantially reduce symptoms and/or functional impairment. Medications are effective for core symptoms and are usually well tolerated. Some non-pharmacological treatments are valuable, especially for improving adaptive functioning. Clinical and neurobiological research is ongoing and could lead to the creation of personalized diagnostic and therapeutic approaches for this disorder.

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NRDP ADHD Revision - Accepted Manuscript
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Accepted/In Press date: 16 January 2024
Published date: 22 February 2024

Identifiers

Local EPrints ID: 488835
URI: http://eprints.soton.ac.uk/id/eprint/488835
PURE UUID: 6d72b55d-6b63-46a8-a5ef-6973f4643a42
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075

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Date deposited: 08 Apr 2024 16:32
Last modified: 22 Aug 2024 04:01

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Contributors

Author: Stephen V. Faraone
Author: Mark A. Bellgrove
Author: Isabell Brikell
Author: Samuele Cortese ORCID iD
Author: Catharina A. Hartman
Author: Chris Hollis
Author: Jeffrey H. Newcorn
Author: Alexandra Philipsen
Author: Guilherme V. Polanczyk
Author: Katya Rubia
Author: Margaret H. Sibley
Author: Jan K. Buitelaar

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