Attention-deficit/hyperactivity disorder
Attention-deficit/hyperactivity disorder
Attention-deficit/hyperactivity disorder (ADHD; also known as hyperkinetic disorder) is a common neurodevelopmental condition that affects children and adults worldwide. ADHD has a predominantly genetic aetiology that involves common and rare genetic variants. Some environmental correlates of the disorder have been discovered but causation has been difficult to establish. The heterogeneity of the condition is evident in the diverse presentation of symptoms and levels of impairment, the numerous co-occurring mental and physical conditions, the various domains of neurocognitive impairment, and extensive minor structural and functional brain differences. The diagnosis of ADHD is reliable and valid when evaluated with standard diagnostic criteria. Curative treatments for ADHD do not exist but evidence-based treatments substantially reduce symptoms and/or functional impairment. Medications are effective for core symptoms and are usually well tolerated. Some non-pharmacological treatments are valuable, especially for improving adaptive functioning. Clinical and neurobiological research is ongoing and could lead to the creation of personalized diagnostic and therapeutic approaches for this disorder.
Faraone, Stephen V.
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Bellgrove, Mark A.
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Brikell, Isabell
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Cortese, Samuele
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Hartman, Catharina A.
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Hollis, Chris
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Newcorn, Jeffrey H.
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Philipsen, Alexandra
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Polanczyk, Guilherme V.
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Rubia, Katya
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Sibley, Margaret H.
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Buitelaar, Jan K.
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22 February 2024
Faraone, Stephen V.
11abe086-d301-4ca2-bbd5-d7a516be924f
Bellgrove, Mark A.
fb883055-1139-4f9f-b22e-5a3c1be5be20
Brikell, Isabell
8ce0666a-d578-4128-9385-20358b875b7c
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Hartman, Catharina A.
2a0e21ca-3f73-4558-9755-e456aba83e70
Hollis, Chris
655959e9-0bc4-4d5e-be17-d1d57fecb681
Newcorn, Jeffrey H.
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Philipsen, Alexandra
758b84d4-25eb-4cb9-b853-54fec17eec1e
Polanczyk, Guilherme V.
794ddae7-f894-48fc-a90a-af190ab728a8
Rubia, Katya
5f6c0771-6e32-4924-b3f1-e48ace6de377
Sibley, Margaret H.
8b5d8b52-f07e-4428-b161-c8c2f95372e0
Buitelaar, Jan K.
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Faraone, Stephen V., Bellgrove, Mark A., Brikell, Isabell, Cortese, Samuele, Hartman, Catharina A., Hollis, Chris, Newcorn, Jeffrey H., Philipsen, Alexandra, Polanczyk, Guilherme V., Rubia, Katya, Sibley, Margaret H. and Buitelaar, Jan K.
(2024)
Attention-deficit/hyperactivity disorder.
Nature Reviews Disease Primers, 10 (1), [11].
(doi:10.1038/s41572-024-00495-0).
Abstract
Attention-deficit/hyperactivity disorder (ADHD; also known as hyperkinetic disorder) is a common neurodevelopmental condition that affects children and adults worldwide. ADHD has a predominantly genetic aetiology that involves common and rare genetic variants. Some environmental correlates of the disorder have been discovered but causation has been difficult to establish. The heterogeneity of the condition is evident in the diverse presentation of symptoms and levels of impairment, the numerous co-occurring mental and physical conditions, the various domains of neurocognitive impairment, and extensive minor structural and functional brain differences. The diagnosis of ADHD is reliable and valid when evaluated with standard diagnostic criteria. Curative treatments for ADHD do not exist but evidence-based treatments substantially reduce symptoms and/or functional impairment. Medications are effective for core symptoms and are usually well tolerated. Some non-pharmacological treatments are valuable, especially for improving adaptive functioning. Clinical and neurobiological research is ongoing and could lead to the creation of personalized diagnostic and therapeutic approaches for this disorder.
Text
NRDP ADHD Revision
- Accepted Manuscript
More information
Accepted/In Press date: 16 January 2024
Published date: 22 February 2024
Identifiers
Local EPrints ID: 488835
URI: http://eprints.soton.ac.uk/id/eprint/488835
PURE UUID: 6d72b55d-6b63-46a8-a5ef-6973f4643a42
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Date deposited: 08 Apr 2024 16:32
Last modified: 22 Aug 2024 04:01
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Contributors
Author:
Stephen V. Faraone
Author:
Mark A. Bellgrove
Author:
Isabell Brikell
Author:
Catharina A. Hartman
Author:
Chris Hollis
Author:
Jeffrey H. Newcorn
Author:
Alexandra Philipsen
Author:
Guilherme V. Polanczyk
Author:
Katya Rubia
Author:
Margaret H. Sibley
Author:
Jan K. Buitelaar
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