Acute appendicitis and ulcerative colitis: a population-based sibling comparison study
Acute appendicitis and ulcerative colitis: a population-based sibling comparison study
Objective: to assess the inverse relationship between acute appendicitis and ulcerative colitis (UC) using a sibling comparison design to adjust for unmeasured familial genetic and environmental factors.
Design: the cohort comprised 3.1 million individuals resident in Sweden between 1984 and 2018 with the linkage of several Swedish national registers. Fitting Cox hazards models, we calculated the risk for developing UC in individuals with and without acute appendicitis by the age 20 years adjusting for several potential confounding factors. Further, we performed sibling-stratified analyses to adjust for shared unmeasured familial confounding factors.
Results: during 57.7 million person-years of follow-up, 20 848/3 125 232 developed UC among those without appendicitis (3.63 (3.59–3.68) per 10 000 person-years), whereas only 59/35 848 people developed UC among those with appendicitis before age 20 years (1.66 (1.28–2.14) per 10 000 person-years). We found a decreased risk for developing UC in those with acute appendicitis by the age 20 years compared with individuals who did not have appendicitis by this age (HR=0.37 (95% CI 0.29 to 0.48)). When adjusting for shared familial confounders, we observed only a slight attenuation in this association (HR=0.46 (95% CI 0.32 to 0.66)).
Conclusion: individuals who had acute appendicitis by late adolescence showed a decreased risk for developing UC compared with those who did not. Genetic and shared familial environmental factors seem to potentially play only a small role in this relationship. Our results suggest an independent association of acute appendicitis, or its underlying causes, with UC risk.
Garcia-Argibay, Miguel
e5a6941e-4dcc-401a-9de4-09557c8856ef
Hiyoshi, Ayako
4755811b-d7c7-43a0-b187-bc8e52dafe01
Montgomery, Scott
38108870-54a5-4c25-8028-31bb04febd91
Garcia-Argibay, Miguel
e5a6941e-4dcc-401a-9de4-09557c8856ef
Hiyoshi, Ayako
4755811b-d7c7-43a0-b187-bc8e52dafe01
Montgomery, Scott
38108870-54a5-4c25-8028-31bb04febd91
Garcia-Argibay, Miguel, Hiyoshi, Ayako and Montgomery, Scott
(2022)
Acute appendicitis and ulcerative colitis: a population-based sibling comparison study.
BMJ Open Gastroenterology, 9 (1), [e001041].
(doi:10.1136/bmjgast-2022-001041).
Abstract
Objective: to assess the inverse relationship between acute appendicitis and ulcerative colitis (UC) using a sibling comparison design to adjust for unmeasured familial genetic and environmental factors.
Design: the cohort comprised 3.1 million individuals resident in Sweden between 1984 and 2018 with the linkage of several Swedish national registers. Fitting Cox hazards models, we calculated the risk for developing UC in individuals with and without acute appendicitis by the age 20 years adjusting for several potential confounding factors. Further, we performed sibling-stratified analyses to adjust for shared unmeasured familial confounding factors.
Results: during 57.7 million person-years of follow-up, 20 848/3 125 232 developed UC among those without appendicitis (3.63 (3.59–3.68) per 10 000 person-years), whereas only 59/35 848 people developed UC among those with appendicitis before age 20 years (1.66 (1.28–2.14) per 10 000 person-years). We found a decreased risk for developing UC in those with acute appendicitis by the age 20 years compared with individuals who did not have appendicitis by this age (HR=0.37 (95% CI 0.29 to 0.48)). When adjusting for shared familial confounders, we observed only a slight attenuation in this association (HR=0.46 (95% CI 0.32 to 0.66)).
Conclusion: individuals who had acute appendicitis by late adolescence showed a decreased risk for developing UC compared with those who did not. Genetic and shared familial environmental factors seem to potentially play only a small role in this relationship. Our results suggest an independent association of acute appendicitis, or its underlying causes, with UC risk.
Text
e001041.full
- Version of Record
More information
Accepted/In Press date: 17 November 2022
e-pub ahead of print date: 29 November 2022
Identifiers
Local EPrints ID: 489000
URI: http://eprints.soton.ac.uk/id/eprint/489000
ISSN: 2054-4774
PURE UUID: 1ace8f61-e49d-4f54-9550-5ddf10c72366
Catalogue record
Date deposited: 10 Apr 2024 16:59
Last modified: 11 Apr 2024 02:09
Export record
Altmetrics
Contributors
Author:
Miguel Garcia-Argibay
Author:
Ayako Hiyoshi
Author:
Scott Montgomery
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics