The University of Southampton
University of Southampton Institutional Repository

Comparison of microfocus- and synchrotron x-ray tomography for the analysis of osteointgration around Ti6Al4V implants

Comparison of microfocus- and synchrotron x-ray tomography for the analysis of osteointgration around Ti6Al4V implants
Comparison of microfocus- and synchrotron x-ray tomography for the analysis of osteointgration around Ti6Al4V implants
Micro-computed tomography (µCT) provides quantitative three-dimensional information of bone around titanium implants similar to classical histology. The study, based on an animal model, using cuboid-shaped biofunctionalised Ti6Al4V implants with surrounding bone after 4 weeks, is performed using 3 µCT-systems with X-ray tubes, one synchrotron-radiation-based µCT-system (SRµCT), and classical histology. Although the spatial resolution of the µCTsystems is comparable, only the results of SRµCT agree with results of classical histology. The X-ray tube sources give rise to huge artefacts in the tomograms (interface scattering, beam hardening), which impaired the quantitative analysis of bone up to about 200 µm from the implant surface. Due to the non-destructive character of µCT the specimens can be subsequently examined by classical histology without restriction. The quantitative comparison of bone formation uncovers the strong dependence of the detected amount of newly formed bone from the selected slice. This implies the necessity of 3D analysis. SRµCT and classical histology prove that surface modifications of the titanium implant significantly influence the bone formation.
x-ray micro computed tomography, comparison of microfocus and synchrotron radiation, osteointegration, surface modification of titanium implants, histology, bone segmentation, quantification of bone formation
42-51
Bernhardt, Ricardo
17fd58fe-42d2-4aa8-8065-d268df6f1081
Scharnweber, Dieter
8883a9f6-7ca1-49c8-ae91-0072e3e3146d
Müller, Bert
acba4294-b684-4a09-81ac-32de31d39923
Beckmann, Felix
9c0d47e5-e36b-4523-b6b6-0d65a708441b
Thurner, Philipp J.
ab711ddd-784e-48de-aaad-f56aec40f84f
Schliephake, Henning
93d542a9-ae9a-4830-8bd7-cd81e1f2399c
Wyss, Peter
37835676-2f92-4df7-bc35-97b2c80c1104
Beckmann, F.
649ec367-ba7d-4d7f-aabb-ae83f3f72cd8
Goebbels, Juergen
b06792fb-6c0c-4a1e-879b-e72d00e8bf1c
Worch, Hartmut
a2d88881-d9b9-4e16-baa7-7019eacb9af1
Bernhardt, Ricardo
17fd58fe-42d2-4aa8-8065-d268df6f1081
Scharnweber, Dieter
8883a9f6-7ca1-49c8-ae91-0072e3e3146d
Müller, Bert
acba4294-b684-4a09-81ac-32de31d39923
Beckmann, Felix
9c0d47e5-e36b-4523-b6b6-0d65a708441b
Thurner, Philipp J.
ab711ddd-784e-48de-aaad-f56aec40f84f
Schliephake, Henning
93d542a9-ae9a-4830-8bd7-cd81e1f2399c
Wyss, Peter
37835676-2f92-4df7-bc35-97b2c80c1104
Beckmann, F.
649ec367-ba7d-4d7f-aabb-ae83f3f72cd8
Goebbels, Juergen
b06792fb-6c0c-4a1e-879b-e72d00e8bf1c
Worch, Hartmut
a2d88881-d9b9-4e16-baa7-7019eacb9af1

Bernhardt, Ricardo, Scharnweber, Dieter, Müller, Bert, Beckmann, Felix, Thurner, Philipp J., Schliephake, Henning, Wyss, Peter, Beckmann, F., Goebbels, Juergen and Worch, Hartmut (2004) Comparison of microfocus- and synchrotron x-ray tomography for the analysis of osteointgration around Ti6Al4V implants. European Cells & Materials, 7, 42-51.

Record type: Article

Abstract

Micro-computed tomography (µCT) provides quantitative three-dimensional information of bone around titanium implants similar to classical histology. The study, based on an animal model, using cuboid-shaped biofunctionalised Ti6Al4V implants with surrounding bone after 4 weeks, is performed using 3 µCT-systems with X-ray tubes, one synchrotron-radiation-based µCT-system (SRµCT), and classical histology. Although the spatial resolution of the µCTsystems is comparable, only the results of SRµCT agree with results of classical histology. The X-ray tube sources give rise to huge artefacts in the tomograms (interface scattering, beam hardening), which impaired the quantitative analysis of bone up to about 200 µm from the implant surface. Due to the non-destructive character of µCT the specimens can be subsequently examined by classical histology without restriction. The quantitative comparison of bone formation uncovers the strong dependence of the detected amount of newly formed bone from the selected slice. This implies the necessity of 3D analysis. SRµCT and classical histology prove that surface modifications of the titanium implant significantly influence the bone formation.

Text
Comparison_of_Microfocus__and_Synchrotron.pdf - Version of Record
Restricted to Repository staff only
Request a copy

More information

Published date: 30 June 2004
Keywords: x-ray micro computed tomography, comparison of microfocus and synchrotron radiation, osteointegration, surface modification of titanium implants, histology, bone segmentation, quantification of bone formation

Identifiers

Local EPrints ID: 48924
URI: https://eprints.soton.ac.uk/id/eprint/48924
PURE UUID: 6364c94d-2496-4b5a-933d-03ca2f29c1c6
ORCID for Philipp J. Thurner: ORCID iD orcid.org/0000-0001-7588-9041

Catalogue record

Date deposited: 18 Oct 2007
Last modified: 19 Jun 2019 00:34

Export record

Contributors

Author: Ricardo Bernhardt
Author: Dieter Scharnweber
Author: Bert Müller
Author: Felix Beckmann
Author: Henning Schliephake
Author: Peter Wyss
Author: F. Beckmann
Author: Juergen Goebbels
Author: Hartmut Worch

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×