Global and regional burden of chronic respiratory disease in 2016 arising from non-infectious airborne occupational exposures: a systematic analysis for the Global Burden of Disease Study 2016
Global and regional burden of chronic respiratory disease in 2016 arising from non-infectious airborne occupational exposures: a systematic analysis for the Global Burden of Disease Study 2016
Objectives: this paper presents detailed analysis of the global and regional burden of chronic respiratory disease arising from occupational airborne exposures, as estimated in the Global Burden of Disease 2016 study.
Methods: the burden of chronic obstructive pulmonary disease (COPD) due to occupational exposure to particulate matter, gases and fumes, and secondhand smoke, and the burden of asthma resulting from occupational exposure to asthmagens, was estimated using the population attributable fraction (PAF), calculated using exposure prevalence and relative risks from the literature. PAFs were applied to the number of deaths and disability-adjusted life years (DALYs) for COPD and asthma. Pneumoconioses were estimated directly from cause of death data. Age-standardised rates were based only on persons aged 15 years and above.
Results: the estimated PAFs (based on DALYs) were 17% (95% uncertainty interval (UI) 14%-20%) for COPD and 10% (95% UI 9%-11%) for asthma. There were estimated to be 519 000 (95% UI 441,000-609,000) deaths from chronic respiratory disease in 2016 due to occupational airborne risk factors (COPD: 460,100 [95% UI 382,000-551,000]; asthma: 37,600 [95% UI 28,400-47,900]; pneumoconioses: 21,500 [95% UI 17,900-25,400]. The equivalent overall burden estimate was 13.6 million (95% UI 11.9-15.5 million); DALYs (COPD: 10.7 [95% UI 9.0-12.5] million; asthma: 2.3 [95% UI 1.9-2.9] million; pneumoconioses: 0.58 [95% UI 0.46-0.67] million). Rates were highest in males; older persons and mainly in Oceania, Asia and sub-Saharan Africa; and decreased from 1990 to 2016.
Conclusions: workplace exposures resulting in COPD, asthma and pneumoconiosis continue to be important contributors to the burden of disease in all regions of the world. This should be reducible through improved prevention and control of relevant exposures.
Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Asthma/epidemiology, Chronic Disease, Disabled Persons/statistics & numerical data, Female, Global Burden of Disease/statistics & numerical data, Global Health/statistics & numerical data, Humans, Life Expectancy, Male, Middle Aged, Occupational Diseases/epidemiology, Occupational Exposure/adverse effects, Pneumoconiosis/epidemiology, Pulmonary Disease, Chronic Obstructive/epidemiology, Quality-Adjusted Life Years, Respiration Disorders/epidemiology, Risk Assessment, Risk Factors, Sex Distribution, Socioeconomic Factors, Young Adult
142-150
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Driscoll, Tim
99df6061-e092-49d1-8b6c-d150873211fa
GBD 2016 Occupational Chronic Respiratory Risk Factors Collaborators
31 March 2020
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Driscoll, Tim
99df6061-e092-49d1-8b6c-d150873211fa
GBD 2016 Occupational Chronic Respiratory Risk Factors Collaborators
(2020)
Global and regional burden of chronic respiratory disease in 2016 arising from non-infectious airborne occupational exposures: a systematic analysis for the Global Burden of Disease Study 2016.
Occupational & Environmental Medicine, 77 (3), .
(doi:10.1136/oemed-2019-106013).
Abstract
Objectives: this paper presents detailed analysis of the global and regional burden of chronic respiratory disease arising from occupational airborne exposures, as estimated in the Global Burden of Disease 2016 study.
Methods: the burden of chronic obstructive pulmonary disease (COPD) due to occupational exposure to particulate matter, gases and fumes, and secondhand smoke, and the burden of asthma resulting from occupational exposure to asthmagens, was estimated using the population attributable fraction (PAF), calculated using exposure prevalence and relative risks from the literature. PAFs were applied to the number of deaths and disability-adjusted life years (DALYs) for COPD and asthma. Pneumoconioses were estimated directly from cause of death data. Age-standardised rates were based only on persons aged 15 years and above.
Results: the estimated PAFs (based on DALYs) were 17% (95% uncertainty interval (UI) 14%-20%) for COPD and 10% (95% UI 9%-11%) for asthma. There were estimated to be 519 000 (95% UI 441,000-609,000) deaths from chronic respiratory disease in 2016 due to occupational airborne risk factors (COPD: 460,100 [95% UI 382,000-551,000]; asthma: 37,600 [95% UI 28,400-47,900]; pneumoconioses: 21,500 [95% UI 17,900-25,400]. The equivalent overall burden estimate was 13.6 million (95% UI 11.9-15.5 million); DALYs (COPD: 10.7 [95% UI 9.0-12.5] million; asthma: 2.3 [95% UI 1.9-2.9] million; pneumoconioses: 0.58 [95% UI 0.46-0.67] million). Rates were highest in males; older persons and mainly in Oceania, Asia and sub-Saharan Africa; and decreased from 1990 to 2016.
Conclusions: workplace exposures resulting in COPD, asthma and pneumoconiosis continue to be important contributors to the burden of disease in all regions of the world. This should be reducible through improved prevention and control of relevant exposures.
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Accepted/In Press date: 30 November 2019
e-pub ahead of print date: 13 February 2020
Published date: 31 March 2020
Keywords:
Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Asthma/epidemiology, Chronic Disease, Disabled Persons/statistics & numerical data, Female, Global Burden of Disease/statistics & numerical data, Global Health/statistics & numerical data, Humans, Life Expectancy, Male, Middle Aged, Occupational Diseases/epidemiology, Occupational Exposure/adverse effects, Pneumoconiosis/epidemiology, Pulmonary Disease, Chronic Obstructive/epidemiology, Quality-Adjusted Life Years, Respiration Disorders/epidemiology, Risk Assessment, Risk Factors, Sex Distribution, Socioeconomic Factors, Young Adult
Identifiers
Local EPrints ID: 489335
URI: http://eprints.soton.ac.uk/id/eprint/489335
ISSN: 1351-0711
PURE UUID: 6097e872-ba88-4756-9b6c-2a44f168edf4
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Date deposited: 22 Apr 2024 16:30
Last modified: 23 Apr 2024 01:35
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Author:
Tim Driscoll
Corporate Author: GBD 2016 Occupational Chronic Respiratory Risk Factors Collaborators
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