Can progressive and non-progressive behavioural variant frontotemporal dementia be distinguished at presentation?

Hornberger, M., Shelley, B.P., Kipps, C.M., Piguet, O. and Hodges, J.R. (2009) Can progressive and non-progressive behavioural variant frontotemporal dementia be distinguished at presentation? Journal of Neurology, Neurosurgery, and Psychiatry, 80, 591-593. (doi:10.1136/jnnp.2008.163873).

Abstract

Background: recent findings suggest that patients with behavioural variant frontotemporal dementia (bv-FTD) differ in their disease progression (progressive vs non-progressive patients). The current study investigates whether the two groups can be discriminated by their clinical features at first presentation.

Methods: archival clinical data of the Early Onset Dementia Clinic, Cambridge, UK, were analysed for 71 patients with bv-FTD: 45 progressive and 26 non-progressive cases with more than 3 years of follow-up.

Results: the subgroups were largely indistinguishable on the basis of the presenting clinical features but could be distinguished on general cognitive (Addenbrooke’s Cognitive Examination-revised) and selected supportive diagnostic features (distractibility, stereotypic speech, impaired activities of daily living (ADLs) and current depression).

Conclusions: progressive and non-progressive patients are difficult to differentiate on the basis of current clinical diagnostic criteria for FTD but a combination of general cognitive, executive dysfunction and impaired ADL measures appear to be the most promising discriminators.

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Contributors

Author: C.M. Kipps

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