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Lifetime alcohol use disorder and gambling disorder: clinical profile and treatment response

Lifetime alcohol use disorder and gambling disorder: clinical profile and treatment response
Lifetime alcohol use disorder and gambling disorder: clinical profile and treatment response
Objectives: gambling disorder affects 0.5-2.4% of the population and shows strong associations with lifetime alcohol use disorder. Very little is known regarding whether lifetime alcohol use disorder can impact the clinical presentation or outcome trajectory of gambling disorder.

Methods: data were pooled from previous clinical trials conducted in people with gambling disorder none of whom had current alcohol use disorder. Demographic and clinical variables were compared between those who did versus did not have lifetime alcohol use disorder.

Results: of the 621 participants in the clinical trials, 103 (16.6%) had a lifetime history of alcohol use disorder. History of alcohol use disorder was significantly associated with male gender (Relative Risk (RR) = 1.42), greater body weight (Cohen’s D=0.27), family history of alcohol use disorder in first-degree relative(s) (RR = 1.46), occurrence of previous hospitalization due to psychiatric illness (RR = 2.68), and higher gambling-related legal problems (RR = 1.50). History of alcohol use disorder was not significantly associated with other variables that were examined, such as severity of gambling disorder or extent of functional disability. Lifetime alcohol use disorder was not significantly associated with extent of clinical improvement in gambling disorder symptoms during the subsequent clinical trials.

Conclusions: these data highlight that lifetime alcohol use disorder is an important clinical variable to be considered when assessing gambling disorder, since it is associated with several untoward features (especially gambling-related legal problems and prior psychiatric hospitalization). The study design enabled these associations to be disambiguated from current or recent alcohol use disorder.
Alcohol, Gambling, Treatment
1092-8529
Chamberlain, Sam
8a0e09e6-f51f-4039-9287-88debe8d8b6f
Ioannidis, Konstaninos
0d2044c9-ed1c-4e92-be40-397e99999f4b
Grant, Jon E.
07372bd5-8a0d-42b4-b41b-e376c652acf3
Chamberlain, Sam
8a0e09e6-f51f-4039-9287-88debe8d8b6f
Ioannidis, Konstaninos
0d2044c9-ed1c-4e92-be40-397e99999f4b
Grant, Jon E.
07372bd5-8a0d-42b4-b41b-e376c652acf3

Chamberlain, Sam, Ioannidis, Konstaninos and Grant, Jon E. (2024) Lifetime alcohol use disorder and gambling disorder: clinical profile and treatment response. CNS Spectrums. (In Press)

Record type: Article

Abstract

Objectives: gambling disorder affects 0.5-2.4% of the population and shows strong associations with lifetime alcohol use disorder. Very little is known regarding whether lifetime alcohol use disorder can impact the clinical presentation or outcome trajectory of gambling disorder.

Methods: data were pooled from previous clinical trials conducted in people with gambling disorder none of whom had current alcohol use disorder. Demographic and clinical variables were compared between those who did versus did not have lifetime alcohol use disorder.

Results: of the 621 participants in the clinical trials, 103 (16.6%) had a lifetime history of alcohol use disorder. History of alcohol use disorder was significantly associated with male gender (Relative Risk (RR) = 1.42), greater body weight (Cohen’s D=0.27), family history of alcohol use disorder in first-degree relative(s) (RR = 1.46), occurrence of previous hospitalization due to psychiatric illness (RR = 2.68), and higher gambling-related legal problems (RR = 1.50). History of alcohol use disorder was not significantly associated with other variables that were examined, such as severity of gambling disorder or extent of functional disability. Lifetime alcohol use disorder was not significantly associated with extent of clinical improvement in gambling disorder symptoms during the subsequent clinical trials.

Conclusions: these data highlight that lifetime alcohol use disorder is an important clinical variable to be considered when assessing gambling disorder, since it is associated with several untoward features (especially gambling-related legal problems and prior psychiatric hospitalization). The study design enabled these associations to be disambiguated from current or recent alcohol use disorder.

Text
gambling_and_lifetimealcohol_04-02-24 - Accepted Manuscript
Restricted to Repository staff only until 23 October 2024.
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More information

Accepted/In Press date: 23 April 2024
Keywords: Alcohol, Gambling, Treatment

Identifiers

Local EPrints ID: 489529
URI: http://eprints.soton.ac.uk/id/eprint/489529
ISSN: 1092-8529
PURE UUID: 8642eaa3-be05-4387-860c-2deee95ab6ca
ORCID for Sam Chamberlain: ORCID iD orcid.org/0000-0001-7014-8121

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Date deposited: 26 Apr 2024 16:40
Last modified: 30 Aug 2024 02:00

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Contributors

Author: Sam Chamberlain ORCID iD
Author: Konstaninos Ioannidis
Author: Jon E. Grant

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