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Non-destructive three-dimensional evaluation of a polymer sponge by micro-tomography using synchrotron radiation

Müller, Bert, Beckmann, Felix, Huser, Marius, Maspero, Fabrice A., Szekely, Gabor, Ruffieux, Kurt, Thurner, Philipp and Wintermantel, Erich (2002) Non-destructive three-dimensional evaluation of a polymer sponge by micro-tomography using synchrotron radiation Biomolecular Engineering, 19, (2-6), pp. 73-78. (doi:10.1016/S1389-0344(02)00014-X).

Record type: Article


X-ray micro-tomography, a non-destructive technique is used to uncover the complex 3-D micro-architecture of a degradable polymer sponge designed for bone augmentation. The measurements performed at HASYLAB at DESY are based on a synchrotron radiation source resulting in a spatial resolution of about 5.4 microm. In the present communication we report the quantitative analysis of the porosity and of the pore architecture. First, we elucidate that synchrotron radiation at the photon energy of 9 keV has an appropriate cross section for this low-weight material. Modifications in sponge micro-architecture during measurement are not detected. Second, the treatment of the data, an amount of 2.5 Gbyte to generate binary data is described. We compare the 3-D with the 2-D analysis in a quantitative manner. The obtained values for the mean distance to material within the sponge calculated from 2-D and 3-D data of the whole tomogram differ significantly: 12.5 microm for 3-D and 17.6 microm for 2-D analysis. If the pores exhibit a spherical shape as frequently found, the derived mean pore diameter, however, is overestimated only by 6% in the 2-D image analysis with respect to the 3-D evaluation. This approach can be applied to different porous biomaterials and composites even in a hydrated state close to physiological conditions, where any surface preparation artifact is avoided.

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Published date: August 2002
Keywords: biodegradable scaffold, X-ray microtomography, synchrotron radiation, three-dimensional image analysis, porosity


Local EPrints ID: 48954
ISSN: 1389-0344
PURE UUID: ca879047-4b2c-494f-9658-a06b19c3d01f

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Date deposited: 18 Oct 2007
Last modified: 17 Jul 2017 14:57

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Author: Bert Müller
Author: Felix Beckmann
Author: Marius Huser
Author: Fabrice A. Maspero
Author: Gabor Szekely
Author: Kurt Ruffieux
Author: Philipp Thurner
Author: Erich Wintermantel

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