The inflammatory response in the CNS
The inflammatory response in the CNS
In recent years it has been recognized that cells of the mononuclear phagocyte lineage, macrophages and microglia, are a major component of gliosis. We review here studies on the kinetics of the myelomonocytic response to acute excitotoxin induced neuronal degeneration and following the injection of endotoxin (LPS) into the parenchyma of the central nervous system. These studies have shown that the kinetics of myelomonocytic recruitment to the parenchyma of the central nervous system is quite unlike that of other tissues; the polymorphonuclear cells are largely excluded and monocytes are only recruited after a delay of several days. The unusual nature of the inflammatory response in the central nervous system needs to be considered when drawing parallels with the acute inflammatory response in other tissues.
Central nervous system, Excitotoxin, Inflammation, Lipopolysaccharide, Macrophage, Microglia
454-459
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Andersson, P.B.
64c40047-7670-47a8-8426-b527113e4d04
October 1992
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Andersson, P.B.
64c40047-7670-47a8-8426-b527113e4d04
Abstract
In recent years it has been recognized that cells of the mononuclear phagocyte lineage, macrophages and microglia, are a major component of gliosis. We review here studies on the kinetics of the myelomonocytic response to acute excitotoxin induced neuronal degeneration and following the injection of endotoxin (LPS) into the parenchyma of the central nervous system. These studies have shown that the kinetics of myelomonocytic recruitment to the parenchyma of the central nervous system is quite unlike that of other tissues; the polymorphonuclear cells are largely excluded and monocytes are only recruited after a delay of several days. The unusual nature of the inflammatory response in the central nervous system needs to be considered when drawing parallels with the acute inflammatory response in other tissues.
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Accepted/In Press date: 18 May 1992
Published date: October 1992
Keywords:
Central nervous system, Excitotoxin, Inflammation, Lipopolysaccharide, Macrophage, Microglia
Identifiers
Local EPrints ID: 489562
URI: http://eprints.soton.ac.uk/id/eprint/489562
ISSN: 0305-1846
PURE UUID: 6c38b2ee-5259-401b-8ce3-1b801c7daf6c
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Date deposited: 29 Apr 2024 16:30
Last modified: 29 Apr 2024 16:30
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Author:
P.B. Andersson
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