Altered antigen expression of microglia in the aged rodent CNS
Altered antigen expression of microglia in the aged rodent CNS
Microglia, the resident macrophages of the central nervous system, are characterised by a highly specialized morphology and unusual antigenic phenotype. Microglia appear to be downregulated by their microenvironment when compared to other tissue macrophages. We have studied the microglia in brains of healthy, aged rats with a panel of monoclonal antibodies. We have found that microglia in the brains of these aged rats express antigens that are downregulated or absent from microglia of juvenile rats. The stimuli which give rise to this upregulated phenotype are not known. Age related changes in the phenotype of microglia should be taken into account when considering the possible role of microglia in neuropathological conditions.
Aging, Macrophage, Upregulation
60-67
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Matyszak, M.K.
937943f3-d8c0-45fd-bcc2-df29f06ce9a2
Fearn, S.
29233c91-d325-46b7-81a2-c057c815d3a2
January 1993
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Matyszak, M.K.
937943f3-d8c0-45fd-bcc2-df29f06ce9a2
Fearn, S.
29233c91-d325-46b7-81a2-c057c815d3a2
Perry, V.H., Matyszak, M.K. and Fearn, S.
(1993)
Altered antigen expression of microglia in the aged rodent CNS.
GLIA, 7 (1), .
(doi:10.1002/glia.440070111).
Abstract
Microglia, the resident macrophages of the central nervous system, are characterised by a highly specialized morphology and unusual antigenic phenotype. Microglia appear to be downregulated by their microenvironment when compared to other tissue macrophages. We have studied the microglia in brains of healthy, aged rats with a panel of monoclonal antibodies. We have found that microglia in the brains of these aged rats express antigens that are downregulated or absent from microglia of juvenile rats. The stimuli which give rise to this upregulated phenotype are not known. Age related changes in the phenotype of microglia should be taken into account when considering the possible role of microglia in neuropathological conditions.
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Published date: January 1993
Keywords:
Aging, Macrophage, Upregulation
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Local EPrints ID: 489564
URI: http://eprints.soton.ac.uk/id/eprint/489564
ISSN: 0894-1491
PURE UUID: 74b29837-a7e0-4a6a-ae3d-326da80f0ecc
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Date deposited: 29 Apr 2024 16:30
Last modified: 29 Apr 2024 16:30
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Author:
M.K. Matyszak
Author:
S. Fearn
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