Macrophages and inflammation in the central nervous system
Macrophages and inflammation in the central nervous system
Acute inflammation plays an important role in host tissue defense against injury and infection, and also subsequent tissue repair. In the central nervous system parenchyma, following many types of insults, the acute inflammatory response to rapid neuronal degeneration or challenge with inflammatory substances differs dramatically from that of other tissues. The rapid recruitment of neutrophils is virtually absent and monocytes are only recruited after a delay of several days. It appears that the microenvironment of the central nervous system has evolved mechanisms to protect it from the potentially damaging consequences of some aspects of the acute inflammatory response.
268-273
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Andersson, Peter Brian
64c40047-7670-47a8-8426-b527113e4d04
Gordon, Siamon
df664ae8-6319-4b1a-8f16-49f4a5fe760f
July 1993
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Andersson, Peter Brian
64c40047-7670-47a8-8426-b527113e4d04
Gordon, Siamon
df664ae8-6319-4b1a-8f16-49f4a5fe760f
Perry, V. Hugh, Andersson, Peter Brian and Gordon, Siamon
(1993)
Macrophages and inflammation in the central nervous system.
Trends in Neurosciences, 16 (7), .
(doi:10.1016/0166-2236(93)90180-T).
Abstract
Acute inflammation plays an important role in host tissue defense against injury and infection, and also subsequent tissue repair. In the central nervous system parenchyma, following many types of insults, the acute inflammatory response to rapid neuronal degeneration or challenge with inflammatory substances differs dramatically from that of other tissues. The rapid recruitment of neutrophils is virtually absent and monocytes are only recruited after a delay of several days. It appears that the microenvironment of the central nervous system has evolved mechanisms to protect it from the potentially damaging consequences of some aspects of the acute inflammatory response.
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Published date: July 1993
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Local EPrints ID: 489568
URI: http://eprints.soton.ac.uk/id/eprint/489568
ISSN: 0166-2236
PURE UUID: d15a8908-879c-47b3-8055-10b7b294e53b
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Date deposited: 29 Apr 2024 16:30
Last modified: 05 Jun 2024 19:54
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Author:
Peter Brian Andersson
Author:
Siamon Gordon
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