The blood-brain barrier and the inflammatory response
The blood-brain barrier and the inflammatory response
The environment of the brain is controlled by a sophisticated endothelial barrier that prevents the free entry of solutes from the blood. It is commonly assumed that this blood-brain barrier (BBB) also prevents the entry of leukocytes into the central nervous system. However, recent evidence in animal models shows that this is not the case, and leukocytes can cross an intact BBB during health and disease. Indeed, in many neurological diseases, including Alzheimer's disease, prion diseases and AIDS-related dementia, leukocytes enter the brain parenchyma without concomitant BBB breakdown. Current research is concentrating on factors that control the integrity of the BBB and the mechanisms that leukocytes use to enter the brain.
335-341
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Anthony, D.C.
928249fa-dcf4-4088-b95b-ce14c719164d
Bolton, S.J.
23f45f2c-bce7-4017-8cdc-65ba32f6db18
Brown, H.C.
697c19ce-7395-4d8c-88c4-cf509269e31a
August 1997
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Anthony, D.C.
928249fa-dcf4-4088-b95b-ce14c719164d
Bolton, S.J.
23f45f2c-bce7-4017-8cdc-65ba32f6db18
Brown, H.C.
697c19ce-7395-4d8c-88c4-cf509269e31a
Perry, V.H., Anthony, D.C., Bolton, S.J. and Brown, H.C.
(1997)
The blood-brain barrier and the inflammatory response.
Molecular Medicine Today, 3 (8), .
(doi:10.1016/S1357-4310(97)01077-0).
Abstract
The environment of the brain is controlled by a sophisticated endothelial barrier that prevents the free entry of solutes from the blood. It is commonly assumed that this blood-brain barrier (BBB) also prevents the entry of leukocytes into the central nervous system. However, recent evidence in animal models shows that this is not the case, and leukocytes can cross an intact BBB during health and disease. Indeed, in many neurological diseases, including Alzheimer's disease, prion diseases and AIDS-related dementia, leukocytes enter the brain parenchyma without concomitant BBB breakdown. Current research is concentrating on factors that control the integrity of the BBB and the mechanisms that leukocytes use to enter the brain.
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Published date: August 1997
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Local EPrints ID: 489609
URI: http://eprints.soton.ac.uk/id/eprint/489609
ISSN: 1357-4310
PURE UUID: afea8eee-618e-45de-b888-e19c1f9ac51f
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Date deposited: 29 Apr 2024 16:46
Last modified: 29 Apr 2024 16:46
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Author:
D.C. Anthony
Author:
S.J. Bolton
Author:
H.C. Brown
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