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Mannan-binding lectin in human serum, cerebrospinal fluid and brain tissue and its role in Alzheimer's disease

Mannan-binding lectin in human serum, cerebrospinal fluid and brain tissue and its role in Alzheimer's disease
Mannan-binding lectin in human serum, cerebrospinal fluid and brain tissue and its role in Alzheimer's disease

Mannan-binding lectin (MBL) is a serum lectin which can activate the classical complement pathway. Complement proteins of the classical pathway have been found in the brains of patients with Alzheimer's disease (AD) in association with AD brain pathology. To investigate the role for MBL in AD we have looked for its presence in the brain by immunohistochemistry and determined the levels of MBL in paired samples of cerebrospinal fluid and serum from AD patients and controls. MBL was detected in association with blood vessels in the brain tissue of both AD patients and control subjects. There was no apparent difference in the distribution of MBL in the brain tissue between the two groups. The mean concentration of MBL in the CSF was 44% lower in AD patients than in controls (AD 154 ± 35 pg/ml, n = 19; non- AD 276 ± 50 pg/ml, n = 15, p < 0.05). The levels of MBL in serum were not significantly different in the two groups. Thus, this study shows that MBL is associated with blood vessels in the brains of both AD and control subjects. Moreover, CSF levels of MBL appear to be lower in AD patients than in control subjects which may indicate a higher degree of MBL consumption connected with complement activation in the AD patients.

Alzheimer's disease, Brain tissue, Cerebrospinal fluid, Mannan-binding lectin, Serum, Time-resolved immunofluorometric assay
0959-4965
1491-1495
Lanzrein, Anne-Sophie
573039e2-fbec-4bb9-a479-f3b28b1b5cb8
Jobst, Kim A.
c072cd9a-eac8-48bd-827f-0084c1e39b45
Thiel, Steffen
cba49931-8764-481f-aef4-4b5b1aab548c
Jensenius, Jens Christian
9a7ecb43-14e7-4e45-8e56-6d6cc2353fee
Sim, Robert B.
d48628cc-2ae8-4a8c-949a-4d5c35a514ec
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Sim, Edith
76b9b428-c005-44d0-972d-edbf3b169443
et al.
Lanzrein, Anne-Sophie
573039e2-fbec-4bb9-a479-f3b28b1b5cb8
Jobst, Kim A.
c072cd9a-eac8-48bd-827f-0084c1e39b45
Thiel, Steffen
cba49931-8764-481f-aef4-4b5b1aab548c
Jensenius, Jens Christian
9a7ecb43-14e7-4e45-8e56-6d6cc2353fee
Sim, Robert B.
d48628cc-2ae8-4a8c-949a-4d5c35a514ec
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Sim, Edith
76b9b428-c005-44d0-972d-edbf3b169443

Lanzrein, Anne-Sophie, Jobst, Kim A. and Thiel, Steffen , et al. (1998) Mannan-binding lectin in human serum, cerebrospinal fluid and brain tissue and its role in Alzheimer's disease. NeuroReport, 9 (7), 1491-1495. (doi:10.1097/00001756-199805110-00045).

Record type: Article

Abstract

Mannan-binding lectin (MBL) is a serum lectin which can activate the classical complement pathway. Complement proteins of the classical pathway have been found in the brains of patients with Alzheimer's disease (AD) in association with AD brain pathology. To investigate the role for MBL in AD we have looked for its presence in the brain by immunohistochemistry and determined the levels of MBL in paired samples of cerebrospinal fluid and serum from AD patients and controls. MBL was detected in association with blood vessels in the brain tissue of both AD patients and control subjects. There was no apparent difference in the distribution of MBL in the brain tissue between the two groups. The mean concentration of MBL in the CSF was 44% lower in AD patients than in controls (AD 154 ± 35 pg/ml, n = 19; non- AD 276 ± 50 pg/ml, n = 15, p < 0.05). The levels of MBL in serum were not significantly different in the two groups. Thus, this study shows that MBL is associated with blood vessels in the brains of both AD and control subjects. Moreover, CSF levels of MBL appear to be lower in AD patients than in control subjects which may indicate a higher degree of MBL consumption connected with complement activation in the AD patients.

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More information

Published date: 11 May 1998
Keywords: Alzheimer's disease, Brain tissue, Cerebrospinal fluid, Mannan-binding lectin, Serum, Time-resolved immunofluorometric assay

Identifiers

Local EPrints ID: 489617
URI: http://eprints.soton.ac.uk/id/eprint/489617
ISSN: 0959-4965
PURE UUID: 8ac73373-ed35-4bf7-9363-52880ab79a76

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Date deposited: 29 Apr 2024 16:47
Last modified: 05 Jun 2024 18:10

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Contributors

Author: Anne-Sophie Lanzrein
Author: Kim A. Jobst
Author: Steffen Thiel
Author: Jens Christian Jensenius
Author: Robert B. Sim
Author: V. Hugh Perry
Author: Edith Sim
Corporate Author: et al.

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