Lobar atrophy in frontotemporal dementia: diagnostic and prognostic implications
Lobar atrophy in frontotemporal dementia: diagnostic and prognostic implications
We review the practical importance of lobar atrophy in frontotemporal dementia (FTD), for diagnosis and prognosis. We discuss specific patterns of frontotemporal atrophy that denote clinical and pathological subtypes of FTD (e.g. semantic dementia). We also discuss the unsatisfactory clinical experience of interpreting MRI scans in individual FTD cases, especially the behavioural presentations (without aphasic or motor impairments). This issue is explored by examining the FTD phenocopy concept. Lobar atrophy emerges as a key observation in defining behavioural FTD patients whose symptoms are likely to progress. In a situation where objective clinical data are few, we highlight the importance of applying caution before diagnosing FTD is the absence of visible brain atrophy.
Atrophy, Disease Progression, Frontal Lobe/pathology, Frontotemporal Dementia/pathology, Humans, Prognosis, Temporal Lobe/pathology
261-265
Davies, R.R.
93e75a43-2637-40d5-aa38-b91e1c08076d
Kipps, C.M.
e43be016-2dc2-45e6-9a02-ab2a0e0208d5
May 2011
Davies, R.R.
93e75a43-2637-40d5-aa38-b91e1c08076d
Kipps, C.M.
e43be016-2dc2-45e6-9a02-ab2a0e0208d5
Davies, R.R. and Kipps, C.M.
(2011)
Lobar atrophy in frontotemporal dementia: diagnostic and prognostic implications.
Current Alzheimer Research, 8 (3), .
(doi:10.2174/156720511795563818).
Abstract
We review the practical importance of lobar atrophy in frontotemporal dementia (FTD), for diagnosis and prognosis. We discuss specific patterns of frontotemporal atrophy that denote clinical and pathological subtypes of FTD (e.g. semantic dementia). We also discuss the unsatisfactory clinical experience of interpreting MRI scans in individual FTD cases, especially the behavioural presentations (without aphasic or motor impairments). This issue is explored by examining the FTD phenocopy concept. Lobar atrophy emerges as a key observation in defining behavioural FTD patients whose symptoms are likely to progress. In a situation where objective clinical data are few, we highlight the importance of applying caution before diagnosing FTD is the absence of visible brain atrophy.
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Published date: May 2011
Keywords:
Atrophy, Disease Progression, Frontal Lobe/pathology, Frontotemporal Dementia/pathology, Humans, Prognosis, Temporal Lobe/pathology
Identifiers
Local EPrints ID: 489679
URI: http://eprints.soton.ac.uk/id/eprint/489679
ISSN: 1567-2050
PURE UUID: effe07ca-d4eb-4bb9-9bdb-b6b2cad7a34b
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Date deposited: 30 Apr 2024 16:46
Last modified: 01 May 2024 01:56
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Author:
R.R. Davies
Author:
C.M. Kipps
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