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Functional microimaging: an integrated approach for advanced bone biomechanics and failure analysis

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Biomechanical testing is the gold standard to determine bone competence, and has been used extensively. Direct mechanical testing provides detailed information on overall bone mechanical and material properties, but fails in revealing local properties such as local deformations and strains or quantification of fracture progression. Therefore, we incorporated several imaging methods in our mechanical setups in order to get a better insight into bone deformation and failure characteristics. Our aim was to develop an integrative approach for hierarchical investigation of bone, working at different scales of resolution ranging from the whole bone to its ultrastructure. At a macroscopic level, we used high-resolution and high-speed cameras which drastically increased the amount of information obtained from a biomechanical bone test. The new image data proved especially important when dealing with very small bones such as the murine femur. Here the feedback of the camera in the process of aligning and positioning the samples is indispensable for reproducibility. In addition, global failure behavior and fracture initiation can now be visualized with high temporal resolution. At a microscopic level, bone microstructure, i.e. trabecular architecture and cortical porosity, are known to influence bone strength and failure mechanisms significantly. For this reason, we developed an image-guided failure assessment technique, also referred to as functional microimaging, allowing direct time-lapsed 3D visualization and computation of local displacements and strains for better quantification of fracture initiation and progression at the microscopic level. While the resolution of typical desktop micro-computed tomography is around a few micrometers, highly brilliant X-rays from synchrotron radiation permit to explore the nanometer world. This allowed, for the first time, to uncover fully nondestructively the 3D ultrastructure of bone including vascular and cellular structures and to investigate their role in development of bone microcracks in an unprecedented resolution. We conclude that functional microimaging, i.e. the combination of biomechanical testing with non-destructive 3D imaging and visualization are extremely valuable in studying bone failure mechanisms. Functional investigation of microcrack initiation and propagation will lead to a better understanding of the relative contribution of bone mass and bone quality to bone competence.

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Citation

Voide, Romain, Van Lenthe, G. Harry, Schneider, Philipp, Thurner, Philipp J., Wyss, Peter, Sennhauser, Urs, Stampanoni, Marco, Stauber, Martin, Snedeker, Jess and Müller, Ralph (2006) Functional microimaging: an integrated approach for advanced bone biomechanics and failure analysis In, Manduca, Armando and Amini, Amir A. (eds.) Medical Imaging 2006: Physiology, Function, and Structure from Medical Images. Bellingham, US, International Society for Optical Engineering 61430X-[12pp]. (Proceedings of SPIE, 6143). (doi:10.1117/12.650485).

More information

Published date: 13 March 2006

Identifiers

Local EPrints ID: 49049
URI: http://eprints.soton.ac.uk/id/eprint/49049
PURE UUID: 64a8979c-e7ab-424f-9da0-c83dccba564e
ORCID for Philipp Schneider: ORCID iD orcid.org/0000-0001-7499-3576

Catalogue record

Date deposited: 22 Oct 2007
Last modified: 17 Jul 2017 14:57

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Contributors

Author: Romain Voide
Author: G. Harry Van Lenthe
Author: Peter Wyss
Author: Urs Sennhauser
Author: Marco Stampanoni
Author: Martin Stauber
Author: Jess Snedeker
Author: Ralph Müller
Editor: Armando Manduca
Editor: Amir A. Amini

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