Long-term occupational exposures on disability-free survival and mortality in older adults
Long-term occupational exposures on disability-free survival and mortality in older adults
Background: the impact of long-term occupational exposures on health in older adults is increasingly relevant as populations age. To date, no studies have reported their impact on survival free of disability in older adults.
Aims: we aimed to investigate the association between long-term occupational exposure and disability-free survival (DFS), all-cause mortality and cause-specific mortality in initially healthy older adults.
Methods: we analysed data from 12 215 healthy participants in the ASPirin in Reducing Events in the Elderly (ASPREE) study whose mean age was 75 years. Their work history was collated with the ‘ALOHA-plus JEM’ (Job Exposure Matrix) to assign occupational exposures. The primary endpoint, DFS, was a composite measure of death, dementia or persistent physical disability. The secondary endpoint, mortality, was classified according to the underlying cause. Cox proportional hazard models were used to calculate hazard ratios and 95% confidence intervals, adjusted for confounders.
Results: a total of 1835 individuals reached the DFS endpoint during the median 4.7 years follow-up period. Both ever-high and cumulative exposure to all dusts and all pesticides during a person’s working years were associated with reduced DFS. Compared to no exposure, men with high exposure to dusts and pesticides had a reduced DFS. Neither of these exposures were significantly associated with all-cause mortality. Men with high occupational exposure to solvents and women exposed to dusts experienced higher all-cause and cancer-related mortality.
Conclusions: long-term occupational exposure to all dusts and pesticides was associated with a reduced DFS and increased mortality in community-dwelling healthy older adults.
Male, Humans, Female, Aged, Aspirin, Occupational Exposure/adverse effects, Dust, Pesticides, Risk Factors
492-499
Alif, S.M.
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Benke, G.P.
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Kromhout, H.
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Vermeulen, R.
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Tran, C.
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Ronaldson, K.
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Walker-Bone, K.
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Woods, R.
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Beilin, L.
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Tonkin, A.
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Owen, A.J.
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McNeil, J.J.
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8 November 2023
Alif, S.M.
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Benke, G.P.
1ca1723c-7145-46c9-91ce-2e53cfd0c002
Kromhout, H.
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Vermeulen, R.
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Tran, C.
bf97ba73-8790-41d6-ab9f-1323296c0558
Ronaldson, K.
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Walker-Bone, K.
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Woods, R.
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Beilin, L.
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Tonkin, A.
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Owen, A.J.
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McNeil, J.J.
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Alif, S.M., Benke, G.P., Kromhout, H., Vermeulen, R., Tran, C., Ronaldson, K., Walker-Bone, K., Woods, R., Beilin, L., Tonkin, A., Owen, A.J. and McNeil, J.J.
(2023)
Long-term occupational exposures on disability-free survival and mortality in older adults.
Occupational medicine (Oxford, England), 73 (8), .
(doi:10.1093/occmed/kqad105).
Abstract
Background: the impact of long-term occupational exposures on health in older adults is increasingly relevant as populations age. To date, no studies have reported their impact on survival free of disability in older adults.
Aims: we aimed to investigate the association between long-term occupational exposure and disability-free survival (DFS), all-cause mortality and cause-specific mortality in initially healthy older adults.
Methods: we analysed data from 12 215 healthy participants in the ASPirin in Reducing Events in the Elderly (ASPREE) study whose mean age was 75 years. Their work history was collated with the ‘ALOHA-plus JEM’ (Job Exposure Matrix) to assign occupational exposures. The primary endpoint, DFS, was a composite measure of death, dementia or persistent physical disability. The secondary endpoint, mortality, was classified according to the underlying cause. Cox proportional hazard models were used to calculate hazard ratios and 95% confidence intervals, adjusted for confounders.
Results: a total of 1835 individuals reached the DFS endpoint during the median 4.7 years follow-up period. Both ever-high and cumulative exposure to all dusts and all pesticides during a person’s working years were associated with reduced DFS. Compared to no exposure, men with high exposure to dusts and pesticides had a reduced DFS. Neither of these exposures were significantly associated with all-cause mortality. Men with high occupational exposure to solvents and women exposed to dusts experienced higher all-cause and cancer-related mortality.
Conclusions: long-term occupational exposure to all dusts and pesticides was associated with a reduced DFS and increased mortality in community-dwelling healthy older adults.
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kqad105
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Published date: 8 November 2023
Keywords:
Male, Humans, Female, Aged, Aspirin, Occupational Exposure/adverse effects, Dust, Pesticides, Risk Factors
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Local EPrints ID: 490493
URI: http://eprints.soton.ac.uk/id/eprint/490493
ISSN: 0962-7480
PURE UUID: 25ccb759-ab75-4fbe-9398-d3309176741c
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Date deposited: 28 May 2024 17:09
Last modified: 29 May 2024 01:36
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Contributors
Author:
S.M. Alif
Author:
G.P. Benke
Author:
H. Kromhout
Author:
R. Vermeulen
Author:
C. Tran
Author:
K. Ronaldson
Author:
R. Woods
Author:
L. Beilin
Author:
A. Tonkin
Author:
A.J. Owen
Author:
J.J. McNeil
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