pH-responsive motors and their interaction with RAW 264.7 macrophages
pH-responsive motors and their interaction with RAW 264.7 macrophages
Nano/micromotors are self-propelled particles that use external stimuli to gain locomotion outperforming Brownian motion. Here, three different polymers are employed that are conjugated to silica particles through a pH-labile linker. At slightly acidic pH, the linkers hydrolyze and release the polymeric chains, resulting in enhanced locomotion. The motors show a maximum velocity of ≈3 µm s−1 in cell media when poly(ethylene glycol) methyl ether methacrylate is asymmetrically distributed on the surface of the particles. Further, the motor internalization by RAW 264.7 macrophages was compared between motors, which have the polymer conjugated via a pH-labile linker, and the irresponsive particles. Preliminary data indicate enhanced uptake, but further efforts are required to use responsive polymers to propel motors inside mammalian cells.
Ramos-Docampo, Miguel A.
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Qian, Xiaomin
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Ade, Carina
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Marcelino, Thais Floriano
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Ceccato, Marcel
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Foss, Morten
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Hovorka, Ondrej
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Städler, Brigitte
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6 January 2023
Ramos-Docampo, Miguel A.
e41ae666-4eb7-404e-96c8-89d7bc6c4424
Qian, Xiaomin
bc98e7fe-e579-4ce5-8c27-d6adf3a94df3
Ade, Carina
7c230d87-916f-4a99-83b3-9c33094afebe
Marcelino, Thais Floriano
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Ceccato, Marcel
41c07206-09f5-46f3-ad27-7ea914f65c8d
Foss, Morten
2cd35998-e24c-4a6c-bef9-4ea727fa5f98
Hovorka, Ondrej
a12bd550-ad45-4963-aa26-dd81dd1609ee
Städler, Brigitte
022ff948-fa52-4fcd-afa8-202d3a46e73d
Ramos-Docampo, Miguel A., Qian, Xiaomin, Ade, Carina, Marcelino, Thais Floriano, Ceccato, Marcel, Foss, Morten, Hovorka, Ondrej and Städler, Brigitte
(2023)
pH-responsive motors and their interaction with RAW 264.7 macrophages.
Advanced Materials Interfaces, 10 (1), [2201509].
(doi:10.1002/admi.202201509).
Abstract
Nano/micromotors are self-propelled particles that use external stimuli to gain locomotion outperforming Brownian motion. Here, three different polymers are employed that are conjugated to silica particles through a pH-labile linker. At slightly acidic pH, the linkers hydrolyze and release the polymeric chains, resulting in enhanced locomotion. The motors show a maximum velocity of ≈3 µm s−1 in cell media when poly(ethylene glycol) methyl ether methacrylate is asymmetrically distributed on the surface of the particles. Further, the motor internalization by RAW 264.7 macrophages was compared between motors, which have the polymer conjugated via a pH-labile linker, and the irresponsive particles. Preliminary data indicate enhanced uptake, but further efforts are required to use responsive polymers to propel motors inside mammalian cells.
Text
Adv Materials Inter - 2022 - Ramos Docampo - pH‐Responsive Motors and their Interaction with RAW 264 7 Macrophages
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e-pub ahead of print date: 10 October 2022
Published date: 6 January 2023
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Local EPrints ID: 490658
URI: http://eprints.soton.ac.uk/id/eprint/490658
PURE UUID: 46fd3a06-e88a-4961-be3c-e76f277b7d5e
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Date deposited: 03 Jun 2024 16:31
Last modified: 04 Jun 2024 01:45
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Author:
Miguel A. Ramos-Docampo
Author:
Xiaomin Qian
Author:
Carina Ade
Author:
Thais Floriano Marcelino
Author:
Marcel Ceccato
Author:
Morten Foss
Author:
Brigitte Städler
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