Object-oriented lumped-parameter modeling of the cardiovascular system for physiological and pathophysiological conditions
Object-oriented lumped-parameter modeling of the cardiovascular system for physiological and pathophysiological conditions
In this work, a lumped-parameter Windkessel model of the cardiovascular system that simulates biomechanical parameters of the human physiology is presented. The object-oriented platform provided by the MATLAB-based modeling environment SIMSCAPE is employed to compute blood pressures and flows in each heart chamber and at various sites of the vascular tree. The hydraulic domain allows the determination of cardiovascular hemodynamics intuitively from geometrical and mechanical properties of the system, while custom elements model the pumping action of the heart and the effects of respiration on blood flow. The model is validated by comparing predicted hemodynamics with normal physiology during both systole and diastole, demonstrating that changes in arterial pressures with breathing are consistent with reported physiological effects of cardiorespiratory coupling. The capabilities of this platform are explored through two exemplary case studies: i) pressure-overload heart failure due to aortic constriction, validated in vitro and via finite element analysis, and ii) single-ventricle Fontan physiology, validated in vitro and compared with the clinical literature. This platform provides a practical tool for the calculation of cardiovascular hemodynamics from hydraulic parameters, enabling the intuitive creation of in silico representations of complex circulatory loops, the planning and optimization of medical interventions, and the prediction of clinically relevant patient-specific hemodynamics.
cardiovascular system, Fontan circulation, lumped-parameter models, object-oriented modeling, pressure-overload heart failure, SIMSCAPE, Windkessel model
Rosalia, Luca
e3f00c11-aa4f-4454-ba25-cd0fd5cfb20a
Ozturk, Caglar
70bbd3bd-fc56-48e8-8b5e-00d5270c1526
Van Story, David
bfca9f56-911d-4806-bcd8-19e05a1bb506
Horvath, Markus A.
aa6a081c-ed8e-4da8-9281-287413561cdf
Roche, Ellen T.
63e632c8-d821-4c2f-a728-aaf331a5c2a1
9 March 2021
Rosalia, Luca
e3f00c11-aa4f-4454-ba25-cd0fd5cfb20a
Ozturk, Caglar
70bbd3bd-fc56-48e8-8b5e-00d5270c1526
Van Story, David
bfca9f56-911d-4806-bcd8-19e05a1bb506
Horvath, Markus A.
aa6a081c-ed8e-4da8-9281-287413561cdf
Roche, Ellen T.
63e632c8-d821-4c2f-a728-aaf331a5c2a1
Rosalia, Luca, Ozturk, Caglar, Van Story, David, Horvath, Markus A. and Roche, Ellen T.
(2021)
Object-oriented lumped-parameter modeling of the cardiovascular system for physiological and pathophysiological conditions.
Advanced Theory and Simulations, 4 (3), [2000216].
(doi:10.1002/adts.202000216).
Abstract
In this work, a lumped-parameter Windkessel model of the cardiovascular system that simulates biomechanical parameters of the human physiology is presented. The object-oriented platform provided by the MATLAB-based modeling environment SIMSCAPE is employed to compute blood pressures and flows in each heart chamber and at various sites of the vascular tree. The hydraulic domain allows the determination of cardiovascular hemodynamics intuitively from geometrical and mechanical properties of the system, while custom elements model the pumping action of the heart and the effects of respiration on blood flow. The model is validated by comparing predicted hemodynamics with normal physiology during both systole and diastole, demonstrating that changes in arterial pressures with breathing are consistent with reported physiological effects of cardiorespiratory coupling. The capabilities of this platform are explored through two exemplary case studies: i) pressure-overload heart failure due to aortic constriction, validated in vitro and via finite element analysis, and ii) single-ventricle Fontan physiology, validated in vitro and compared with the clinical literature. This platform provides a practical tool for the calculation of cardiovascular hemodynamics from hydraulic parameters, enabling the intuitive creation of in silico representations of complex circulatory loops, the planning and optimization of medical interventions, and the prediction of clinically relevant patient-specific hemodynamics.
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e-pub ahead of print date: 11 February 2021
Published date: 9 March 2021
Additional Information:
Publisher Copyright:
© 2021 Wiley-VCH GmbH
Keywords:
cardiovascular system, Fontan circulation, lumped-parameter models, object-oriented modeling, pressure-overload heart failure, SIMSCAPE, Windkessel model
Identifiers
Local EPrints ID: 490728
URI: http://eprints.soton.ac.uk/id/eprint/490728
ISSN: 2513-0390
PURE UUID: 30c36c00-bb82-4a74-911c-acb1ced97971
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Date deposited: 04 Jun 2024 17:00
Last modified: 05 Jun 2024 02:09
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Contributors
Author:
Luca Rosalia
Author:
Caglar Ozturk
Author:
David Van Story
Author:
Markus A. Horvath
Author:
Ellen T. Roche
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