Effect of blade curvature on the hemolytic and hydraulic characteristics of a centrifugal blood pump
Effect of blade curvature on the hemolytic and hydraulic characteristics of a centrifugal blood pump
Aims: Impeller design has a significant impact on the overall performance of a blood pump. In this study, the effect of the blade curvature was investigated by performing in silico and in vitro studies on a recently developed centrifugal blood pump. Methods: A computational fluid dynamics study was performed for the flow rates of 3-5 L/min at 2000 r/min. The computational fluid dynamics model was also applied on the US Food and Drug Administration (FDA) benchmark blood pump to validate our computational method. The relative hemolysis index was calculated with the Eulerian hemolysis estimation method for five impellers with the wrap angles ranging from 0° to 240°. Hydraulic experiments were conducted for the validation of computational fluid dynamics results. In addition, the curved-blade impeller (120°) and the straight-blade impeller (0°) were evaluated with in vitro hemolysis tests using human blood. Results: The wrap angle of 120° provided the best hydraulic and hemolytic performance. Pump achieved the physiologic operating pressures and flows with 85-115 mmHg at 2.5-5.9 L/min. Compared to the straight-blade impeller, the 120° model reduces the relative hemolysis index and the plasma-free hemoglobin near 72.8% and 56.7%, respectively. Comparison of in silico and in vitro results indicated the similar trend to the blade curvature. Conclusion: Introducing a blade curvature enhanced the hydrodynamic and hemolytic performance compared to the straight-blade configuration for the investigated centrifugal blood pump. The findings of this study provide new insights into centrifugal blood pump design by examining the influence of the blade curvature.
Blade curvature, Centrifugal blood pump, Computational fluid dynamics, Hemolysis estimation, Impeller design
730-737
Ozturk, Caglar
70bbd3bd-fc56-48e8-8b5e-00d5270c1526
Aka, I. Basar
5178df04-8b70-42a5-9ede-3f2568c683a8
Lazoglu, Ismail
dde74a90-ccd3-452a-a4cf-6dbc8841caf3
Ozturk, Caglar
70bbd3bd-fc56-48e8-8b5e-00d5270c1526
Aka, I. Basar
5178df04-8b70-42a5-9ede-3f2568c683a8
Lazoglu, Ismail
dde74a90-ccd3-452a-a4cf-6dbc8841caf3
Ozturk, Caglar, Aka, I. Basar and Lazoglu, Ismail
(2018)
Effect of blade curvature on the hemolytic and hydraulic characteristics of a centrifugal blood pump.
International Journal of Artificial Organs, 41 (11), .
(doi:10.1177/0391398818785558).
Abstract
Aims: Impeller design has a significant impact on the overall performance of a blood pump. In this study, the effect of the blade curvature was investigated by performing in silico and in vitro studies on a recently developed centrifugal blood pump. Methods: A computational fluid dynamics study was performed for the flow rates of 3-5 L/min at 2000 r/min. The computational fluid dynamics model was also applied on the US Food and Drug Administration (FDA) benchmark blood pump to validate our computational method. The relative hemolysis index was calculated with the Eulerian hemolysis estimation method for five impellers with the wrap angles ranging from 0° to 240°. Hydraulic experiments were conducted for the validation of computational fluid dynamics results. In addition, the curved-blade impeller (120°) and the straight-blade impeller (0°) were evaluated with in vitro hemolysis tests using human blood. Results: The wrap angle of 120° provided the best hydraulic and hemolytic performance. Pump achieved the physiologic operating pressures and flows with 85-115 mmHg at 2.5-5.9 L/min. Compared to the straight-blade impeller, the 120° model reduces the relative hemolysis index and the plasma-free hemoglobin near 72.8% and 56.7%, respectively. Comparison of in silico and in vitro results indicated the similar trend to the blade curvature. Conclusion: Introducing a blade curvature enhanced the hydrodynamic and hemolytic performance compared to the straight-blade configuration for the investigated centrifugal blood pump. The findings of this study provide new insights into centrifugal blood pump design by examining the influence of the blade curvature.
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e-pub ahead of print date: 12 July 2018
Additional Information:
Publisher Copyright:
© The Author(s) 2018.
Keywords:
Blade curvature, Centrifugal blood pump, Computational fluid dynamics, Hemolysis estimation, Impeller design
Identifiers
Local EPrints ID: 490731
URI: http://eprints.soton.ac.uk/id/eprint/490731
ISSN: 0391-3988
PURE UUID: 35ff67e7-3279-42a3-9434-9c4cd994e0dd
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Date deposited: 04 Jun 2024 17:00
Last modified: 05 Jun 2024 02:09
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Author:
Caglar Ozturk
Author:
I. Basar Aka
Author:
Ismail Lazoglu
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