Recompensation in MASLD-related cirrhosis via metabolic bariatric surgery
Recompensation in MASLD-related cirrhosis via metabolic bariatric surgery
The prognosis of patients with decompensated cirrhosis is poor, with significantly increased liver-related mortality rates. With the rising tide of decompensated cirrhosis associated with metabolic dysfunction-associated steatotic liver disease (MASLD), the role of metabolic bariatric surgery (MBS) in achieving hepatic recompensation is garnering increasing attention. However, the complexity of preoperative assessment, the risk of postoperative disease recurrence, and the potential for patients to experience surgical complications of the MBS present challenges. In this opinion article we analyze the potential of MBS to induce recompensation in MASLD-related cirrhosis, discuss the mechanisms by which MBS may affect recompensation, and compare the characteristics of different MBS procedures; we highlight the therapeutic potential of MBS in MASLD-related cirrhosis recompensation and advocate for research in this complex area.
bariatric surgery, metabolic dysfunction-associated steatohepatitis, metabolic dysfunction-associated steatotic liver disease, metabolic-associated fatty liver disease, recompensation
Feng, Gong
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Han, Yu
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Yang, Wah
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Shikora, Scott
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Mahawar, Kamal
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Cheung, Tan To
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Targher, Giovanni
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Byrne, Christopher D.
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Hernandez-Gea, Virginia
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Tilg, Herbert
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Zheng, Ming-Hua
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21 June 2024
Feng, Gong
d652a6dd-1490-4890-b242-a0f090febebc
Han, Yu
137573a2-5472-4a4b-9f86-ea6cd15b91d6
Yang, Wah
d264ddf6-9321-44be-925c-956d8f8cd34f
Shikora, Scott
099aad03-3f7f-4c07-8c26-6ad684b0afd3
Mahawar, Kamal
91cfa590-8eca-4fc1-bb0b-427f79b6b09e
Cheung, Tan To
90670053-ea85-48b2-a7a7-588e66977e49
Targher, Giovanni
e4b10156-e05e-4eb1-a722-a7e0e116d881
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Hernandez-Gea, Virginia
e09041e2-bda4-4ec5-8b32-44d901aed036
Tilg, Herbert
6a1283ec-6cb0-4d4f-83d9-438b086c1839
Zheng, Ming-Hua
60d73427-f91f-420f-aa0e-eeb002677e01
Feng, Gong, Han, Yu, Yang, Wah, Shikora, Scott, Mahawar, Kamal, Cheung, Tan To, Targher, Giovanni, Byrne, Christopher D., Hernandez-Gea, Virginia, Tilg, Herbert and Zheng, Ming-Hua
(2024)
Recompensation in MASLD-related cirrhosis via metabolic bariatric surgery.
Trends in Endocrinology & Metabolism.
(doi:10.1016/j.tem.2024.05.009).
Abstract
The prognosis of patients with decompensated cirrhosis is poor, with significantly increased liver-related mortality rates. With the rising tide of decompensated cirrhosis associated with metabolic dysfunction-associated steatotic liver disease (MASLD), the role of metabolic bariatric surgery (MBS) in achieving hepatic recompensation is garnering increasing attention. However, the complexity of preoperative assessment, the risk of postoperative disease recurrence, and the potential for patients to experience surgical complications of the MBS present challenges. In this opinion article we analyze the potential of MBS to induce recompensation in MASLD-related cirrhosis, discuss the mechanisms by which MBS may affect recompensation, and compare the characteristics of different MBS procedures; we highlight the therapeutic potential of MBS in MASLD-related cirrhosis recompensation and advocate for research in this complex area.
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Accepted/In Press date: 31 May 2024
e-pub ahead of print date: 21 June 2024
Published date: 21 June 2024
Additional Information:
Publisher Copyright:
© 2024 Elsevier Ltd
Keywords:
bariatric surgery, metabolic dysfunction-associated steatohepatitis, metabolic dysfunction-associated steatotic liver disease, metabolic-associated fatty liver disease, recompensation
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Local EPrints ID: 490910
URI: http://eprints.soton.ac.uk/id/eprint/490910
ISSN: 1043-2760
PURE UUID: b48b06fa-03ba-4bdf-9801-a16a666e28fc
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Date deposited: 07 Jun 2024 17:50
Last modified: 10 Aug 2024 01:36
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Contributors
Author:
Gong Feng
Author:
Yu Han
Author:
Wah Yang
Author:
Scott Shikora
Author:
Kamal Mahawar
Author:
Tan To Cheung
Author:
Giovanni Targher
Author:
Virginia Hernandez-Gea
Author:
Herbert Tilg
Author:
Ming-Hua Zheng
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