READ ME File For Dataset for thesis 'Colonisation dynamics of Bordetella pertussis and Neisseria lactamica in the nasopharynx during experimental asymptomatic infection in humans'

Dataset DOI:  https://doi.org/10.5258/SOTON/D3101

ReadMe Author: Mukhtar Mohammed Ibrahim, University of Southampton ORCID ID:0000-0002-2027-3095

This dataset supports the thesis entitled 'olonisation dynamics of Bordetella pertussis and Neisseria lactamica in the nasopharynx during experimental asymptomatic infection in humans'

AWARDED BY: Univeristy of Southampton
DATE OF AWARD: 2024

DESCRIPTION OF THE DATA
This data was generated by bacterial culture and qPCR analysis of nasopharyngeal samples collected from human study volunteers. The data is in excel format.

This dataset contains:
QPCR and culture data for the results described in Chapter 3,4,5 and 6 of the thesis.



Date of data collection: [ADD IN COLLECTION DATES]

Information about geographic location of data collection: Studies described in this thesis were conducted in Southampton, United Kingdom

Licence:
CC BY

Related projects/Funders:
ClinicalTrials.gov identifier: NCT03751514 and NCT03630250

Related publication:

Title: de Graaf, H. et al. (2019) ‘Controlled Human Infection With Bordetella pertussis Induces Asymptomatic, Immunizing Colonization’, Clinical Infectious Diseases. doi: 10.1093/cid/ciz840.


Title: Diks, A. M. et al. (2023) ‘Distinct early cellular kinetics in participants protected against colonization upon Bordetella pertussis challenge’, The Journal of Clinical Investigation. The American Society for Clinical Investigation, 133(5). doi: 10.1172/JCI163121. 

Title: Gbesemete, D. et al. (2019) ‘Protocol for a controlled human infection with genetically modified Neisseria lactamica expressing the meningococcal vaccine antigen NadA: A potent new technique for experimental medicine’, BMJ Open, 9(4), pp. 1–10. doi: 10.1136/bmjopen-2018-026544. 

Title: Laver, J. R. et al., (2021) ‘A recombinant commensal bacteria elicits heterologous antigen-specific immune responses during pharyngeal carriage’, Science Translational Medicine, 13(601), p. eabe8573. doi: 10.1126/scitranslmed.abe8573. 

Title: Ramkissoon S, et al., (2020) ‘A qPCR assay for Bordetella pertussis cells that enumerates both live and dead bacteria’. PLOS ONE 15(4): e0232334. https://doi.org/10.1371/journal.pone.02323346. 


Date that the file was created: June, 2024