Tissue factor: a critical role in inflammation and cancer
Tissue factor: a critical role in inflammation and cancer
A series of coordinated enzymatic reactions takes place in the body whenever blood clots. The major physiological initiator of these reactions is a membrane-bound glycoprotein known as tissue factor (TF), which is normally separated from the bloodstream by the vascular endothelium. Bleeding, caused by injury or tissue damage, activates a complex enzyme cascade as TF becomes exposed to the bloodstream. In disease states, leukocytes or the vascular endothelium may abnormally express TF to cause intravascular coagulation. The blood-coagulation cascade is also relevant to diseases such as hemophilia, in which patients are deficient in blood proteins necessary for clotting, and is linked to vascular diseases such as heart attack and stroke, in which clotting can lead to the occlusion of blood vessels. Coagulation is also activated in inflammation and cancer. In this article, we discuss characteristics of TF and review its role in inflammation and cancer.
tissue factor, blood coagulation, inflammation, cancer
97-107
Lwaleed, B.A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Cooper, A.J.
8a21c297-eda3-4479-8e81-1de258c8e2a1
Voegeli, D.
e6f5d112-55b0-40c1-a6ad-8929a2d84a10
Getliffe, K.
3ce38a84-b0ba-46b8-99e1-126de7cc35e7
October 2007
Lwaleed, B.A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Cooper, A.J.
8a21c297-eda3-4479-8e81-1de258c8e2a1
Voegeli, D.
e6f5d112-55b0-40c1-a6ad-8929a2d84a10
Getliffe, K.
3ce38a84-b0ba-46b8-99e1-126de7cc35e7
Lwaleed, B.A., Cooper, A.J., Voegeli, D. and Getliffe, K.
(2007)
Tissue factor: a critical role in inflammation and cancer.
Biological Research for Nursing, 9 (2), .
(doi:10.1177/1099800407305733).
Abstract
A series of coordinated enzymatic reactions takes place in the body whenever blood clots. The major physiological initiator of these reactions is a membrane-bound glycoprotein known as tissue factor (TF), which is normally separated from the bloodstream by the vascular endothelium. Bleeding, caused by injury or tissue damage, activates a complex enzyme cascade as TF becomes exposed to the bloodstream. In disease states, leukocytes or the vascular endothelium may abnormally express TF to cause intravascular coagulation. The blood-coagulation cascade is also relevant to diseases such as hemophilia, in which patients are deficient in blood proteins necessary for clotting, and is linked to vascular diseases such as heart attack and stroke, in which clotting can lead to the occlusion of blood vessels. Coagulation is also activated in inflammation and cancer. In this article, we discuss characteristics of TF and review its role in inflammation and cancer.
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Published date: October 2007
Keywords:
tissue factor, blood coagulation, inflammation, cancer
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Local EPrints ID: 49095
URI: http://eprints.soton.ac.uk/id/eprint/49095
ISSN: 1099-8004
PURE UUID: bbd2c7f2-a35b-4b50-abc0-75a0405df48a
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Date deposited: 24 Oct 2007
Last modified: 06 Aug 2024 01:39
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Author:
A.J. Cooper
Author:
D. Voegeli
Author:
K. Getliffe
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