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The management of sleep disturbances in children with attention-deficit/hyperactivity disorder (ADHD): an update of the literature

The management of sleep disturbances in children with attention-deficit/hyperactivity disorder (ADHD): an update of the literature
The management of sleep disturbances in children with attention-deficit/hyperactivity disorder (ADHD): an update of the literature

Introduction: sleep disorders represent an important comorbidity in individuals with ADHD. While the links between ADHD and sleep disturbances have been extensively investigated, research on the management of sleep disorders in individuals with ADHD is relatively limited, albeit expanding.


Areas covered: the authors searched PubMed, Medline, PsycInfo, Embase+Embase Classic, Web of Sciences databases, and clinicaltrials.gov up to 4 January 2024, for randomized controlled trials (RCTs) of any intervention for sleep disorders associated with ADHD. They retained 16 RCTs (eight on pharmacological and eight on non-pharmacological interventions), supporting behavioral intervention and melatonin, and nine ongoing RCTs registered on clinicaltrials.gov.


Expert opinion: the pool of RCTs testing interventions for sleep disorders in individuals with ADHD is expanding. However, to inform clinical guidelines, there is a need for additional research in several areas, including 1) RCTs based on a precise phenotyping of sleep disorders; 2) pragmatic RCTs recruiting neurodevelopmental populations representative of those seen in clinical services; 3) trials testing alternative interventions (e.g. suvorexant or light therapy) or ways to deliver them (e.g. online); 4) sequential and longer-term RCTs; 5) studies testing the impact of sleep interventions on outcomes other than sleep; 6) and implementation of advanced evidence synthesis and precision medicine approaches.

ADHD, Sleep, insomnia, randomized, treatment
1473-7175
585-596
Cortese, Samuele
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Fusetto Veronesi, Guilherme
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Gabellone, Alessandra
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Margari, Anna
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Marzulli, Lucia
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Matera, Emilia
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Petruzelli, Maria Giuseppina
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Piarulli, Francesco Maria
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Tarantino, Fabio
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Bellato, Alessio
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Parlatini, Valeria
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Rietz, Ebba Du
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Larsson, Henrik
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Hornsey, Samantha
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Hill, Cathy
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Margari, Lucia
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Cortese, Samuele
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Fusetto Veronesi, Guilherme
79cc3314-39ba-4465-a0f8-6b630037b6ba
Gabellone, Alessandra
f1b8d033-0070-49aa-9e0a-3e5e36d17aaf
Margari, Anna
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Marzulli, Lucia
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Matera, Emilia
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Petruzelli, Maria Giuseppina
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Piarulli, Francesco Maria
9585399c-9ba7-43d1-8c99-fcf8e8ecce65
Tarantino, Fabio
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Bellato, Alessio
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Parlatini, Valeria
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Rietz, Ebba Du
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Larsson, Henrik
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Hornsey, Samantha
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Hill, Cathy
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Margari, Lucia
cd19d7f3-f363-433b-a255-f65121b4d543

Cortese, Samuele, Fusetto Veronesi, Guilherme, Gabellone, Alessandra, Margari, Anna, Marzulli, Lucia, Matera, Emilia, Petruzelli, Maria Giuseppina, Piarulli, Francesco Maria, Tarantino, Fabio, Bellato, Alessio, Parlatini, Valeria, Rietz, Ebba Du, Larsson, Henrik, Hornsey, Samantha, Hill, Cathy and Margari, Lucia (2024) The management of sleep disturbances in children with attention-deficit/hyperactivity disorder (ADHD): an update of the literature. Expert Review of Neurotherapeutics, 24 (6), 585-596. (doi:10.1080/14737175.2024.2353692).

Record type: Review

Abstract

Introduction: sleep disorders represent an important comorbidity in individuals with ADHD. While the links between ADHD and sleep disturbances have been extensively investigated, research on the management of sleep disorders in individuals with ADHD is relatively limited, albeit expanding.


Areas covered: the authors searched PubMed, Medline, PsycInfo, Embase+Embase Classic, Web of Sciences databases, and clinicaltrials.gov up to 4 January 2024, for randomized controlled trials (RCTs) of any intervention for sleep disorders associated with ADHD. They retained 16 RCTs (eight on pharmacological and eight on non-pharmacological interventions), supporting behavioral intervention and melatonin, and nine ongoing RCTs registered on clinicaltrials.gov.


Expert opinion: the pool of RCTs testing interventions for sleep disorders in individuals with ADHD is expanding. However, to inform clinical guidelines, there is a need for additional research in several areas, including 1) RCTs based on a precise phenotyping of sleep disorders; 2) pragmatic RCTs recruiting neurodevelopmental populations representative of those seen in clinical services; 3) trials testing alternative interventions (e.g. suvorexant or light therapy) or ways to deliver them (e.g. online); 4) sequential and longer-term RCTs; 5) studies testing the impact of sleep interventions on outcomes other than sleep; 6) and implementation of advanced evidence synthesis and precision medicine approaches.

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The management of sleep disturbances in children with attention-deficit hyperactivity disorder ADHD an update of the literature - Version of Record
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Accepted/In Press date: 7 May 2024
e-pub ahead of print date: 13 May 2024
Published date: 13 May 2024
Additional Information: Publisher Copyright: © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Keywords: ADHD, Sleep, insomnia, randomized, treatment

Identifiers

Local EPrints ID: 491021
URI: http://eprints.soton.ac.uk/id/eprint/491021
ISSN: 1473-7175
PURE UUID: b24a8e41-52ab-4967-a1ae-d78cd56dee82
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075
ORCID for Alessio Bellato: ORCID iD orcid.org/0000-0001-5330-6773
ORCID for Valeria Parlatini: ORCID iD orcid.org/0000-0002-4754-2494
ORCID for Samantha Hornsey: ORCID iD orcid.org/0000-0003-1521-248X

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Date deposited: 11 Jun 2024 16:39
Last modified: 12 Oct 2024 03:00

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Contributors

Author: Samuele Cortese ORCID iD
Author: Guilherme Fusetto Veronesi
Author: Alessandra Gabellone
Author: Anna Margari
Author: Lucia Marzulli
Author: Emilia Matera
Author: Maria Giuseppina Petruzelli
Author: Francesco Maria Piarulli
Author: Fabio Tarantino
Author: Alessio Bellato ORCID iD
Author: Valeria Parlatini ORCID iD
Author: Ebba Du Rietz
Author: Henrik Larsson
Author: Samantha Hornsey ORCID iD
Author: Cathy Hill
Author: Lucia Margari

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