Microneedle-mediated nanomedicine to enhance therapeutic and diagnostic efficacy
Microneedle-mediated nanomedicine to enhance therapeutic and diagnostic efficacy
Nanomedicine has been extensively explored for therapeutic and diagnostic applications in recent years, owing to its numerous advantages such as controlled release, targeted delivery, and efficient protection of encapsulated agents. Integration of microneedle technologies with nanomedicine has the potential to address current limitations in nanomedicine for drug delivery including relatively low therapeutic efficacy and poor patient compliance and enable theragnostic uses. In this Review, we first summarize representative types of nanomedicine and describe their broad applications. We then outline the current challenges faced by nanomedicine, with a focus on issues related to physical barriers, biological barriers, and patient compliance. Next, we provide an overview of microneedle systems, including their definition, manufacturing strategies, drug release mechanisms, and current advantages and challenges. We also discuss the use of microneedle-mediated nanomedicine systems for therapeutic and diagnostic applications. Finally, we provide a perspective on the current status and future prospects for microneedle-mediated nanomedicine for biomedical applications.
Diagnostics, Drug delivery, Microneedle, Nanomedicine, Therapeutics
Zuo, Yuyang
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Sun, Rujie
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Del Piccolo, Nuala
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Stevens, Molly M.
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18 April 2024
Zuo, Yuyang
fc331884-9986-45fe-a64d-8de991aa6ab5
Sun, Rujie
e3dad16d-6c79-4972-8378-edca28a3babd
Del Piccolo, Nuala
c318af4e-181f-4abe-9c82-2e78162a0686
Stevens, Molly M.
2af17549-764e-4c18-a316-f7dc790398e0
Zuo, Yuyang, Sun, Rujie, Del Piccolo, Nuala and Stevens, Molly M.
(2024)
Microneedle-mediated nanomedicine to enhance therapeutic and diagnostic efficacy.
Nano Convergence, 11 (1), [15].
(doi:10.1186/s40580-024-00421-w).
Abstract
Nanomedicine has been extensively explored for therapeutic and diagnostic applications in recent years, owing to its numerous advantages such as controlled release, targeted delivery, and efficient protection of encapsulated agents. Integration of microneedle technologies with nanomedicine has the potential to address current limitations in nanomedicine for drug delivery including relatively low therapeutic efficacy and poor patient compliance and enable theragnostic uses. In this Review, we first summarize representative types of nanomedicine and describe their broad applications. We then outline the current challenges faced by nanomedicine, with a focus on issues related to physical barriers, biological barriers, and patient compliance. Next, we provide an overview of microneedle systems, including their definition, manufacturing strategies, drug release mechanisms, and current advantages and challenges. We also discuss the use of microneedle-mediated nanomedicine systems for therapeutic and diagnostic applications. Finally, we provide a perspective on the current status and future prospects for microneedle-mediated nanomedicine for biomedical applications.
Text
s40580-024-00421-w
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Accepted/In Press date: 26 March 2024
e-pub ahead of print date: 18 April 2024
Published date: 18 April 2024
Keywords:
Diagnostics, Drug delivery, Microneedle, Nanomedicine, Therapeutics
Identifiers
Local EPrints ID: 491097
URI: http://eprints.soton.ac.uk/id/eprint/491097
PURE UUID: f302a0fb-2e8a-4fbe-93b3-a2254e1c3863
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Date deposited: 11 Jun 2024 23:57
Last modified: 11 Nov 2024 17:41
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Contributors
Author:
Yuyang Zuo
Author:
Rujie Sun
Author:
Nuala Del Piccolo
Author:
Molly M. Stevens
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