Magnetically driven formation of 3D freestanding soft bioscaffolds
Magnetically driven formation of 3D freestanding soft bioscaffolds
3D soft bioscaffolds have great promise in tissue engineering, biohybrid robotics, and organ-on-a-chip engineering applications. Though emerging three-dimensional (3D) printing techniques offer versatility for assembling soft biomaterials, challenges persist in overcoming the deformation or collapse of delicate 3D structures during fabrication, especially for overhanging or thin features. This study introduces a magnet-assisted fabrication strategy that uses a magnetic field to trigger shape morphing and provide remote temporary support, enabling the straightforward creation of soft bioscaffolds with overhangs and thin-walled structures in 3D. We demonstrate the versatility and effectiveness of our strategy through the fabrication of bioscaffolds that replicate the complex 3D topology of branching vascular systems. Furthermore, we engineered hydrogel-based bioscaffolds to support biohybrid soft actuators capable of walking motion triggered by cardiomyocytes. This approach opens new possibilities for shaping hydrogel materials into complex 3D morphologies, which will further empower a broad range of biomedical applications.
Xie, Ruoxiao
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Cao, Yuanxiong
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Sun, Rujie
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Wang, Richard
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Morgan, Alexis
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Kim, Junyoung
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Callens, Sebastien J.P.
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Xie, Kai
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Zou, Jiawen
92a253f9-03e8-4c72-a2d4-8c4a8fd8f614
Lin, Junliang
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Zhou, Kun
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Lu, Xiangrong
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Stevens, Molly M.
2af17549-764e-4c18-a316-f7dc790398e0
2 February 2024
Xie, Ruoxiao
e345a1aa-6613-4a23-b5e1-2dbfe9019bac
Cao, Yuanxiong
b8d418fe-92f8-431a-9211-52a7f4e2980a
Sun, Rujie
e3dad16d-6c79-4972-8378-edca28a3babd
Wang, Richard
bc5ae760-6b13-4a5a-b674-63177a98842f
Morgan, Alexis
b42c4de1-ee9c-483f-838e-804d8908a589
Kim, Junyoung
6e357c98-36a8-45e2-b211-bd4603c03b9a
Callens, Sebastien J.P.
f703e6d7-dbfc-4174-a98c-30e539862ae5
Xie, Kai
78d2ced8-7f1d-4b89-ab41-b9920e8d3b14
Zou, Jiawen
92a253f9-03e8-4c72-a2d4-8c4a8fd8f614
Lin, Junliang
53741690-8c04-4803-b4f6-4f3eed167f8e
Zhou, Kun
2bb82231-b6ad-4b96-9b3a-ff3c305436b1
Lu, Xiangrong
62fabbb2-aade-4d08-8e34-74cb93ca3528
Stevens, Molly M.
2af17549-764e-4c18-a316-f7dc790398e0
Xie, Ruoxiao, Cao, Yuanxiong, Sun, Rujie, Wang, Richard, Morgan, Alexis, Kim, Junyoung, Callens, Sebastien J.P., Xie, Kai, Zou, Jiawen, Lin, Junliang, Zhou, Kun, Lu, Xiangrong and Stevens, Molly M.
(2024)
Magnetically driven formation of 3D freestanding soft bioscaffolds.
Science Advances, 10 (5), [eadl1549].
(doi:10.1126/sciadv.adl1549).
Abstract
3D soft bioscaffolds have great promise in tissue engineering, biohybrid robotics, and organ-on-a-chip engineering applications. Though emerging three-dimensional (3D) printing techniques offer versatility for assembling soft biomaterials, challenges persist in overcoming the deformation or collapse of delicate 3D structures during fabrication, especially for overhanging or thin features. This study introduces a magnet-assisted fabrication strategy that uses a magnetic field to trigger shape morphing and provide remote temporary support, enabling the straightforward creation of soft bioscaffolds with overhangs and thin-walled structures in 3D. We demonstrate the versatility and effectiveness of our strategy through the fabrication of bioscaffolds that replicate the complex 3D topology of branching vascular systems. Furthermore, we engineered hydrogel-based bioscaffolds to support biohybrid soft actuators capable of walking motion triggered by cardiomyocytes. This approach opens new possibilities for shaping hydrogel materials into complex 3D morphologies, which will further empower a broad range of biomedical applications.
Text
sciadv.adl1549
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Submitted date: 3 October 2023
Accepted/In Press date: 4 January 2024
Published date: 2 February 2024
Identifiers
Local EPrints ID: 491100
URI: http://eprints.soton.ac.uk/id/eprint/491100
ISSN: 2375-2548
PURE UUID: 2091664a-2488-457c-9ecf-f8b3ff5824bf
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Date deposited: 11 Jun 2024 23:58
Last modified: 12 Jun 2024 00:02
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Contributors
Author:
Ruoxiao Xie
Author:
Yuanxiong Cao
Author:
Rujie Sun
Author:
Richard Wang
Author:
Alexis Morgan
Author:
Junyoung Kim
Author:
Sebastien J.P. Callens
Author:
Kai Xie
Author:
Jiawen Zou
Author:
Junliang Lin
Author:
Kun Zhou
Author:
Xiangrong Lu
Author:
Molly M. Stevens
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