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Fillable magnetic microrobots for drug delivery to cardiac tissues in vitro

Fillable magnetic microrobots for drug delivery to cardiac tissues in vitro
Fillable magnetic microrobots for drug delivery to cardiac tissues in vitro

Many cardiac diseases, such as arrhythmia or cardiogenic shock, cause irregular beating patterns that must be regulated to prevent disease progression toward heart failure. Treatments can include invasive surgery or high systemic drug dosages, which lack precision, localization, and control. Drug delivery systems (DDSs) that can deliver cargo to the cardiac injury site could address these unmet clinical challenges. Here, a microrobotic DDS that can be mobilized to specific sites via magnetic control is presented. This DDS incorporates an internal chamber that can protect drug cargo. Furthermore, the DDS contains a tunable thermosensitive sealing layer that gradually degrades upon exposure to body temperature, enabling prolonged drug release. Once loaded with the small molecule drug norepinephrine, this microrobotic DDS modulated beating frequency in induced pluripotent stem-cell derived cardiomyocytes (iPSC-CMs) in a dose-dependent manner, thus simulating drug delivery to cardiac cells in vitro. The DDS also navigates several maze-like structures seeded with cardiomyocytes to demonstrate precise locomotion under a rotating low-intensity magnetic field and on-site drug delivery. This work demonstrates the utility of a magnetically actuating DDS for precise, localized, and controlled drug delivery which is of interest for a myriad of future opportunities such as in treating cardiac diseases.

cardiac arrhythmias, fillable microrobots, magnetic actuation, phase-change materials, stimuli-responsive drug delivery
2192-2659
Chen, Maggie S.
339335d8-513c-47fc-9ec7-1ccf93f7e9fa
Sun, Rujie
e3dad16d-6c79-4972-8378-edca28a3babd
Wang, Richard
bc5ae760-6b13-4a5a-b674-63177a98842f
Zuo, Yuyang
fc331884-9986-45fe-a64d-8de991aa6ab5
Zhou, Kun
2bb82231-b6ad-4b96-9b3a-ff3c305436b1
Kim, Junyoung
6e357c98-36a8-45e2-b211-bd4603c03b9a
Stevens, Molly M.
2af17549-764e-4c18-a316-f7dc790398e0
Chen, Maggie S.
339335d8-513c-47fc-9ec7-1ccf93f7e9fa
Sun, Rujie
e3dad16d-6c79-4972-8378-edca28a3babd
Wang, Richard
bc5ae760-6b13-4a5a-b674-63177a98842f
Zuo, Yuyang
fc331884-9986-45fe-a64d-8de991aa6ab5
Zhou, Kun
2bb82231-b6ad-4b96-9b3a-ff3c305436b1
Kim, Junyoung
6e357c98-36a8-45e2-b211-bd4603c03b9a
Stevens, Molly M.
2af17549-764e-4c18-a316-f7dc790398e0

Chen, Maggie S., Sun, Rujie, Wang, Richard, Zuo, Yuyang, Zhou, Kun, Kim, Junyoung and Stevens, Molly M. (2024) Fillable magnetic microrobots for drug delivery to cardiac tissues in vitro. Advanced Healthcare Materials, [2400419]. (doi:10.1002/adhm.202400419).

Record type: Article

Abstract

Many cardiac diseases, such as arrhythmia or cardiogenic shock, cause irregular beating patterns that must be regulated to prevent disease progression toward heart failure. Treatments can include invasive surgery or high systemic drug dosages, which lack precision, localization, and control. Drug delivery systems (DDSs) that can deliver cargo to the cardiac injury site could address these unmet clinical challenges. Here, a microrobotic DDS that can be mobilized to specific sites via magnetic control is presented. This DDS incorporates an internal chamber that can protect drug cargo. Furthermore, the DDS contains a tunable thermosensitive sealing layer that gradually degrades upon exposure to body temperature, enabling prolonged drug release. Once loaded with the small molecule drug norepinephrine, this microrobotic DDS modulated beating frequency in induced pluripotent stem-cell derived cardiomyocytes (iPSC-CMs) in a dose-dependent manner, thus simulating drug delivery to cardiac cells in vitro. The DDS also navigates several maze-like structures seeded with cardiomyocytes to demonstrate precise locomotion under a rotating low-intensity magnetic field and on-site drug delivery. This work demonstrates the utility of a magnetically actuating DDS for precise, localized, and controlled drug delivery which is of interest for a myriad of future opportunities such as in treating cardiac diseases.

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Fillable Magnetic Microrobots for Drug Delivery to Cardiac Tissues in Vitro - Accepted Manuscript
Available under License Creative Commons Attribution.
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Adv Healthcare Materials - 2024 - Chen - Fillable Magnetic Microrobots for Drug Delivery to Cardiac Tissues In Vitro - Version of Record
Available under License Creative Commons Attribution.
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More information

Accepted/In Press date: 2024
e-pub ahead of print date: 15 May 2024
Additional Information: For the purpose of open access, the authors have applied a Creative Commons Attribution (CC BY) license to any Author Accepted Manuscript version arising.
Keywords: cardiac arrhythmias, fillable microrobots, magnetic actuation, phase-change materials, stimuli-responsive drug delivery

Identifiers

Local EPrints ID: 491105
URI: http://eprints.soton.ac.uk/id/eprint/491105
ISSN: 2192-2659
PURE UUID: a3073da4-d720-4c95-9a11-b27c730e1c1f

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Date deposited: 12 Jun 2024 16:31
Last modified: 12 Jun 2024 16:31

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Contributors

Author: Maggie S. Chen
Author: Rujie Sun
Author: Richard Wang
Author: Yuyang Zuo
Author: Kun Zhou
Author: Junyoung Kim
Author: Molly M. Stevens

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