Premorbid psychosocial factors are associated with poor health-related quality of life in subjects with new onset of chronic widespread pain - results from the EPIFUND study
Premorbid psychosocial factors are associated with poor health-related quality of life in subjects with new onset of chronic widespread pain - results from the EPIFUND study
Chronic widespread pain (CWP) is associated with poor health-related quality of life (HRQoL). It is unclear whether pain itself is the cause of poor HRQoL or other factors play a role. We hypothesised that new onset of CWP was associated with poor physical and mental HRQoL but that psychosocial risk markers for CWP onset would explain this relationship. A prospective population-based survey measured pain and psychosocial status at baseline. Subjects free of CWP at baseline were followed up 15 months later, when pain status, threatening life events and HRQoL (SF-12) were assessed. The risk associated with the new onset of CWP and reporting poor SF12-MCS and SF12-PCS was quantified using multinomial logistic regression (relative risk ratios (RRRs) with 95% confidence intervals (95% CI)), adjusted for age and gender. 3000 subjects (77%) free of CWP at baseline participated at follow-up. 2650 subjects (88%) provided full SF-12 and pain data and formed the cohort for this analysis. 9.4% of subjects (n = 248) reported new CWP. New CWP was associated with an increased risk of having the poorest SF12-MCS (RRR = 2.3; 95% CI 1.6–3.2) and SF12-PCS (RRR = 8.0; 95% CI 5.4–11.8) scores. After adjusting for baseline psychosocial status, the relationship between CWP onset and SF12-MCS was attenuated (RRR = 1.2; 95% CI 0.8–1.8), although the association with SF12-PCS remained (RRR = 4.8% CI 3.1–7.47). New onset of CWP is associated with poor mental and physical HRQoL. However, the relationship with mental HRQoL is explained by psychosocial risk markers.
119-126
Nicholl, B.I.
3922cf66-6e36-44d2-9d8b-1736123e0e53
Macfarlane, G.J.
e17bbdb7-9d82-42ac-8a0a-09bf10885e3c
Davies, K.A.
67683443-236b-4491-b410-7ae238da790b
Morriss, R.
30d5dc2c-4140-4181-9bbd-a70c6c9dcb17
Dickens, C.
a41afee4-9852-4e66-a96d-938151d8fd3a
McBeth, J.
98012716-66ba-480b-9e43-ac53b51dce61
January 2009
Nicholl, B.I.
3922cf66-6e36-44d2-9d8b-1736123e0e53
Macfarlane, G.J.
e17bbdb7-9d82-42ac-8a0a-09bf10885e3c
Davies, K.A.
67683443-236b-4491-b410-7ae238da790b
Morriss, R.
30d5dc2c-4140-4181-9bbd-a70c6c9dcb17
Dickens, C.
a41afee4-9852-4e66-a96d-938151d8fd3a
McBeth, J.
98012716-66ba-480b-9e43-ac53b51dce61
Nicholl, B.I., Macfarlane, G.J., Davies, K.A., Morriss, R., Dickens, C. and McBeth, J.
(2009)
Premorbid psychosocial factors are associated with poor health-related quality of life in subjects with new onset of chronic widespread pain - results from the EPIFUND study.
Pain, 14 (1), .
(doi:10.1016/j.pain.2008.10.022).
Abstract
Chronic widespread pain (CWP) is associated with poor health-related quality of life (HRQoL). It is unclear whether pain itself is the cause of poor HRQoL or other factors play a role. We hypothesised that new onset of CWP was associated with poor physical and mental HRQoL but that psychosocial risk markers for CWP onset would explain this relationship. A prospective population-based survey measured pain and psychosocial status at baseline. Subjects free of CWP at baseline were followed up 15 months later, when pain status, threatening life events and HRQoL (SF-12) were assessed. The risk associated with the new onset of CWP and reporting poor SF12-MCS and SF12-PCS was quantified using multinomial logistic regression (relative risk ratios (RRRs) with 95% confidence intervals (95% CI)), adjusted for age and gender. 3000 subjects (77%) free of CWP at baseline participated at follow-up. 2650 subjects (88%) provided full SF-12 and pain data and formed the cohort for this analysis. 9.4% of subjects (n = 248) reported new CWP. New CWP was associated with an increased risk of having the poorest SF12-MCS (RRR = 2.3; 95% CI 1.6–3.2) and SF12-PCS (RRR = 8.0; 95% CI 5.4–11.8) scores. After adjusting for baseline psychosocial status, the relationship between CWP onset and SF12-MCS was attenuated (RRR = 1.2; 95% CI 0.8–1.8), although the association with SF12-PCS remained (RRR = 4.8% CI 3.1–7.47). New onset of CWP is associated with poor mental and physical HRQoL. However, the relationship with mental HRQoL is explained by psychosocial risk markers.
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Accepted/In Press date: 29 October 2008
Published date: January 2009
Identifiers
Local EPrints ID: 491255
URI: http://eprints.soton.ac.uk/id/eprint/491255
ISSN: 0304-3959
PURE UUID: 7d258df9-dff2-40ca-9c46-01cf4eb0382e
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Date deposited: 18 Jun 2024 16:48
Last modified: 19 Jun 2024 02:10
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Author:
B.I. Nicholl
Author:
G.J. Macfarlane
Author:
K.A. Davies
Author:
R. Morriss
Author:
C. Dickens
Author:
J. McBeth
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