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Monitoring of chemical reactions within microreactors using an inverted Raman microscopic spectrometer. [In special issue: Proceedings of the APCE 2002 Meeting Shanghai, China, October 11-14, 2002]

Record type: Article

An inverted Raman microscope spectrometer has been used to profile the spatial evolution of reactant and product concentrations for a chemical reaction within a microreactor operating under hydrodynamic flow control. The Raman spectrometer was equipped with a laser source at wavelength of 780 nm, confocal optics, a holographic transmission grating, and a charge-coupled device (CCD) detector. The microreactor consisted of a T-shaped channel network etched within a 0.5 mm thick glass bottom plate that was thermally bonded to a 0.5 mm thick glass top plate. The ends of the channel network were connected to reagent reservoirs that were linked to a syringe pump for driving the solutions by hydrodynamic pumping within the channels. The microchannels were 221 m wide and 73 m deep. The synthesis of ethyl acetate from ethanol and acetic acid was investigated as a model system within the microreactor as Raman scattering bands for each reactant and product species were clearly resolved. Raman spectral intensities of each band were proportional to concentration for each species and hence all concentrations could be quantitatively measured after calibration. By scanning specific Raman bands within a selected area in the microchannel network at given steps in the X-Y plane, spatially resolved concentration profiles were obtained under steady-state flow conditions. Under the flow conditions used, different positions within the concentration profile correspond to different times after contact and mixing of the reagents, thereby enabling one to observe the time dependence of the product formation. Raman microscopy provides a useful complementary technique to UV/VIS absorbance and fluorescence methods for the in situ monitoring and analysis of chemical reaction species having their lowest S0-S1 absorption bands too far in the UV to be of use, due to their probable overlap with the bands from other reactant, product and solvent molecules.

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Citation

Fletcher, Paul D.I., Haswell, Stephen J. and Zhang, Xunli (2003) Monitoring of chemical reactions within microreactors using an inverted Raman microscopic spectrometer. [In special issue: Proceedings of the APCE 2002 Meeting Shanghai, China, October 11-14, 2002] Electrophoresis, 24, (18), pp. 3239-3245. (doi:10.1002/elps.200305532).

More information

Published date: September 2003
Keywords: microreactor, miniaturization, monitoring of chemical reactions, raman microscopic spectroscopy, synthesis of ethyl acetate

Identifiers

Local EPrints ID: 49129
URI: http://eprints.soton.ac.uk/id/eprint/49129
ISSN: 0173-0835
PURE UUID: 0812a124-607f-4e2e-a0da-74489f02c784

Catalogue record

Date deposited: 24 Oct 2007
Last modified: 17 Jul 2017 14:57

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Contributors

Author: Paul D.I. Fletcher
Author: Stephen J. Haswell
Author: Xunli Zhang

University divisions

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