Synthesis and stability studies of bicyclo[6.1.0]nonyne scaffolds for automated solid-phase oligonucleotide synthesis
Synthesis and stability studies of bicyclo[6.1.0]nonyne scaffolds for automated solid-phase oligonucleotide synthesis
Two novel bicyclo[6.1.0]nonyne (BCN) linker derivatives, which can be directly incorporated into oligonucleotide sequences during standard automated solid-phase synthesis, are reported. Stabilities of BCN-carbinol and two BCN-oligonucleotides are evaluated under acidic conditions. In addition, derivatized BCN linkers (non-acidic and acid treated) are evaluated for strain-promoted alkyne-azide cycloaddition (SPAAC).
17406-17412
Karalė, Kristina
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Bollmark, Martin
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Karalius, Antanas
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Lopes, Mónica
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Pérez, Oswaldo
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Strömberg, Roger
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Tedebark, Ulf
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Karalė, Kristina
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Bollmark, Martin
8518b787-dd1f-4bf5-abfb-5479e8d66249
Karalius, Antanas
f1e02833-0f45-441a-a762-dde1cbb7dfa8
Lopes, Mónica
791e65ee-28ff-475b-b5f4-4baff811f64f
Pérez, Oswaldo
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Strömberg, Roger
8fd19843-0c0d-4953-827b-f93719857353
Tedebark, Ulf
ed9527f9-cc70-4bbc-b2d1-0ae6cde9f2bc
Karalė, Kristina, Bollmark, Martin, Karalius, Antanas, Lopes, Mónica, Pérez, Oswaldo, Strömberg, Roger and Tedebark, Ulf
(2024)
Synthesis and stability studies of bicyclo[6.1.0]nonyne scaffolds for automated solid-phase oligonucleotide synthesis.
RSC Advances, 14 (25), .
(doi:10.1039/d3ra08732h).
Abstract
Two novel bicyclo[6.1.0]nonyne (BCN) linker derivatives, which can be directly incorporated into oligonucleotide sequences during standard automated solid-phase synthesis, are reported. Stabilities of BCN-carbinol and two BCN-oligonucleotides are evaluated under acidic conditions. In addition, derivatized BCN linkers (non-acidic and acid treated) are evaluated for strain-promoted alkyne-azide cycloaddition (SPAAC).
Text
d3ra08732h
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Submitted date: 21 December 2023
Accepted/In Press date: 9 May 2024
e-pub ahead of print date: 29 May 2024
Identifiers
Local EPrints ID: 491516
URI: http://eprints.soton.ac.uk/id/eprint/491516
ISSN: 2046-2069
PURE UUID: 3c593464-bc19-46a5-808f-bf5dc8998886
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Date deposited: 25 Jun 2024 16:54
Last modified: 25 Jun 2024 17:00
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Contributors
Author:
Kristina Karalė
Author:
Martin Bollmark
Author:
Antanas Karalius
Author:
Mónica Lopes
Author:
Oswaldo Pérez
Author:
Roger Strömberg
Author:
Ulf Tedebark
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