Myosin 10 is involved in murine pigmentation
Myosin 10 is involved in murine pigmentation
Myosins are molecular motors that are well known for their role in cell movement and contractile functions. Although extensively studied in muscle physiology, little is known about the function of myosins in mammalian skin. As part of the Sanger Institute Mouse Genetics Project, we have identified a role for Myo10 in pigmentation, with a phenotype unlike those of Myo5a or Myo7a. Adult mice homozygous for a disrupted Myo10 allele on a C57BL/6N background displayed a high degree of penetrance for white patches on their abdomen and dorsal surface. Forepaw syndactyly and hind paw syndactyly were also observed in these mice. Tail epidermal wholemounts showed a complete lack of melanocytes in the hair follicles and interfollicular epidermis. Myo10 has previously been implicated in human pigmentation. Our current study reveals involvement of Myo10 in murine skin pigmentation.
Alleles, Animals, Female, Gene Expression, Hair Color/genetics, Hair Follicle/pathology, Male, Melanocytes/metabolism, Mice, Mice, Inbred C57BL, Mice, Knockout, Myosins/genetics, Penetrance, Pigmentation Disorders/genetics, Skin Pigmentation/genetics, Syndactyly/genetics
391-394
Liakath-Ali, Kifayathullah
8d5a020c-e976-4901-9195-68f4bc0de74e
Vancollie, Valerie E.
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Sequeira, Inês
e162db83-bf12-4955-b2fd-14a16f5a037e
Lelliott, Christopher J.
af26504c-561c-4afc-9e0e-26de86f3db8c
Watt, Fiona M.
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April 2019
Liakath-Ali, Kifayathullah
8d5a020c-e976-4901-9195-68f4bc0de74e
Vancollie, Valerie E.
f5178931-9739-4c6d-80d7-eb5945d7226b
Sequeira, Inês
e162db83-bf12-4955-b2fd-14a16f5a037e
Lelliott, Christopher J.
af26504c-561c-4afc-9e0e-26de86f3db8c
Watt, Fiona M.
24fff937-94b0-4127-8cbb-e8bd6e01fa29
Liakath-Ali, Kifayathullah, Vancollie, Valerie E., Sequeira, Inês, Lelliott, Christopher J. and Watt, Fiona M.
(2019)
Myosin 10 is involved in murine pigmentation.
Experimental Dermatology, 28 (4), .
(doi:10.1111/exd.13528).
Abstract
Myosins are molecular motors that are well known for their role in cell movement and contractile functions. Although extensively studied in muscle physiology, little is known about the function of myosins in mammalian skin. As part of the Sanger Institute Mouse Genetics Project, we have identified a role for Myo10 in pigmentation, with a phenotype unlike those of Myo5a or Myo7a. Adult mice homozygous for a disrupted Myo10 allele on a C57BL/6N background displayed a high degree of penetrance for white patches on their abdomen and dorsal surface. Forepaw syndactyly and hind paw syndactyly were also observed in these mice. Tail epidermal wholemounts showed a complete lack of melanocytes in the hair follicles and interfollicular epidermis. Myo10 has previously been implicated in human pigmentation. Our current study reveals involvement of Myo10 in murine skin pigmentation.
Text
Experimental Dermatology - 2018 - Liakath‐Ali - Myosin 10 is involved in murine pigmentation
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More information
e-pub ahead of print date: 6 March 2018
Published date: April 2019
Keywords:
Alleles, Animals, Female, Gene Expression, Hair Color/genetics, Hair Follicle/pathology, Male, Melanocytes/metabolism, Mice, Mice, Inbred C57BL, Mice, Knockout, Myosins/genetics, Penetrance, Pigmentation Disorders/genetics, Skin Pigmentation/genetics, Syndactyly/genetics
Identifiers
Local EPrints ID: 491522
URI: http://eprints.soton.ac.uk/id/eprint/491522
ISSN: 0906-6705
PURE UUID: f7389a24-2e7a-4d40-b732-5f40d62423ed
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Date deposited: 25 Jun 2024 17:00
Last modified: 26 Jun 2024 02:11
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Contributors
Author:
Kifayathullah Liakath-Ali
Author:
Valerie E. Vancollie
Author:
Inês Sequeira
Author:
Christopher J. Lelliott
Author:
Fiona M. Watt
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